Format

Send to:

Choose Destination

OXSR1 oxidative stress responsive kinase 1 [ Homo sapiens (human) ]

Gene ID: 9943, updated on 6-Jan-2019

Summary

Official Symbol
OXSR1provided by HGNC
Official Full Name
oxidative stress responsive kinase 1provided by HGNC
Primary source
HGNC:HGNC:8508
See related
Ensembl:ENSG00000172939 MIM:604046
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OSR1
Summary
The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008]
Annotation information
Note: OSR1 (Gene ID: 130497) and OXSR1 (Gene ID: 9943) share the OSR1 symbol/alias in common. OSR1 is a widely used alternative name for oxidative stress responsive 1 (OXSR1). [29 Jun 2018]
Expression
Ubiquitous expression in esophagus (RPKM 13.6), bone marrow (RPKM 11.2) and 25 other tissues See more
Orthologs

Genomic context

See OXSR1 in Genome Data Viewer
Location:
3p22.2
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (38165051..38255488)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (38207022..38296979)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene DLEC1 cilia and flagella associated protein Neighboring gene acetyl-CoA acyltransferase 1 Neighboring gene uncharacterized LOC101928234 Neighboring gene MYD88, innate immune signal transduction adaptor Neighboring gene cell division cycle 42 pseudogene Neighboring gene solute carrier family 22 member 13 Neighboring gene solute carrier family 22 member 14 Neighboring gene RNA, U6 small nuclear 235, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1101

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular hypotonic response IEA
Inferred from Electronic Annotation
more info
 
cellular response to chemokine IMP
Inferred from Mutant Phenotype
more info
PubMed 
chemokine (C-C motif) ligand 21 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
chemokine (C-X-C motif) ligand 12 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of potassium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
osmosensory signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction by trans-phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
stress-activated protein kinase signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase OSR1
Names
oxidative stress responsive 1
oxidative stress-responsive 1 protein
NP_005100.1
XP_005265695.1
XP_011532633.1
XP_016863090.1
XP_024309619.1
XP_024309620.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005109.3NP_005100.1  serine/threonine-protein kinase OSR1

    See identical proteins and their annotated locations for NP_005100.1

    Status: REVIEWED

    Source sequence(s)
    AB017642, BC008726
    Consensus CDS
    CCDS2675.1
    UniProtKB/Swiss-Prot
    O95747
    UniProtKB/TrEMBL
    A0A024R2M7
    Related
    ENSP00000311713.3, ENST00000311806.7
    Conserved Domains (2) summary
    smart00220
    Location:17291
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06610
    Location:15291
    STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    38165051..38255488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534331.2XP_011532633.1  serine/threonine-protein kinase OSR1 isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:77344
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06610
    Location:77344
    STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase
  2. XM_017007601.1XP_016863090.1  serine/threonine-protein kinase OSR1 isoform X2

  3. XM_024453851.1XP_024309619.1  serine/threonine-protein kinase OSR1 isoform X4

    Conserved Domains (1) summary
    cd06610
    Location:77344
    STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase
  4. XM_005265638.2XP_005265695.1  serine/threonine-protein kinase OSR1 isoform X3

    Conserved Domains (3) summary
    smart00220
    Location:31224
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:367398
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    cl21453
    Location:31224
    PKc_like; Protein Kinases, catalytic domain
  5. XM_024453852.1XP_024309620.1  serine/threonine-protein kinase OSR1 isoform X5

    Conserved Domains (3) summary
    COG0515
    Location:1204
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    pfam12202
    Location:242273
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    cl21453
    Location:199
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_001740396.1 RNA Sequence

  2. XR_001740397.1 RNA Sequence

Support Center