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OXSR1 oxidative stress responsive kinase 1 [ Homo sapiens (human) ]

Gene ID: 9943, updated on 6-Nov-2022

Summary

Official Symbol
OXSR1provided by HGNC
Official Full Name
oxidative stress responsive kinase 1provided by HGNC
Primary source
HGNC:HGNC:8508
See related
Ensembl:ENSG00000172939 MIM:604046; AllianceGenome:HGNC:8508
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OSR1
Summary
The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008]
Annotation information
Note: OSR1 (Gene ID: 130497) and OXSR1 (Gene ID: 9943) share the OSR1 symbol/alias in common. OSR1 is a widely used alternative name for oxidative stress responsive 1 (OXSR1). [29 Jun 2018]
Expression
Ubiquitous expression in esophagus (RPKM 13.6), bone marrow (RPKM 11.2) and 25 other tissues See more
Orthologs
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Genomic context

See OXSR1 in Genome Data Viewer
Location:
3p22.2
Exon count:
23
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (38164063..38255484)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (38171237..38261199)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (38207028..38296975)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene DLEC1 cilia and flagella associated protein Neighboring gene acetyl-CoA acyltransferase 1 Neighboring gene uncharacterized LOC101928234 Neighboring gene MYD88 innate immune signal transduction adaptor Neighboring gene Sharpr-MPRA regulatory region 12810 Neighboring gene solute carrier family 22 member 13 Neighboring gene CDC42 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1101

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular hypotonic response IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to chemokine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chemokine (C-C motif) ligand 21 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in chemokine (C-X-C motif) ligand 12 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of potassium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in osmosensory signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of T cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in extracellular exosome HDA PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase OSR1
Names
oxidative stress responsive 1
oxidative stress-responsive 1 protein
NP_005100.1
XP_011532633.1
XP_016863090.1
XP_024309619.1
XP_024309620.1
XP_047305342.1
XP_047305343.1
XP_047305344.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005109.3NP_005100.1  serine/threonine-protein kinase OSR1

    See identical proteins and their annotated locations for NP_005100.1

    Status: REVIEWED

    Source sequence(s)
    AB017642, BC008726
    Consensus CDS
    CCDS2675.1
    UniProtKB/Swiss-Prot
    O95747, Q9UPQ1
    UniProtKB/TrEMBL
    A0A024R2M7
    Related
    ENSP00000311713.3, ENST00000311806.8
    Conserved Domains (2) summary
    smart00220
    Location:17291
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06610
    Location:15291
    STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    38164063..38255484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534331.3XP_011532633.1  serine/threonine-protein kinase OSR1 isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:77344
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06610
    Location:77344
    STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase
  2. XM_017007601.2XP_016863090.1  serine/threonine-protein kinase OSR1 isoform X2

  3. XM_024453851.2XP_024309619.1  serine/threonine-protein kinase OSR1 isoform X6

    Conserved Domains (1) summary
    cd06610
    Location:77344
    STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase
  4. XM_047449386.1XP_047305342.1  serine/threonine-protein kinase OSR1 isoform X3

  5. XM_047449387.1XP_047305343.1  serine/threonine-protein kinase OSR1 isoform X4

  6. XM_047449388.1XP_047305344.1  serine/threonine-protein kinase OSR1 isoform X5

  7. XM_024453852.2XP_024309620.1  serine/threonine-protein kinase OSR1 isoform X7

    Conserved Domains (3) summary
    COG0515
    Location:1204
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    pfam12202
    Location:242273
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    cl21453
    Location:199
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_007095781.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    38171237..38261199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)