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OXSR1 oxidative stress responsive kinase 1 [ Homo sapiens (human) ]

Gene ID: 9943, updated on 18-Jan-2026
Official Symbol
OXSR1provided by HGNC
Official Full Name
oxidative stress responsive kinase 1provided by HGNC
Primary source
HGNC:HGNC:8508
See related
Ensembl:ENSG00000172939 MIM:604046; AllianceGenome:HGNC:8508
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OSR1
Summary
The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008]
Annotation information
Note: OSR1 (Gene ID: 130497) and OXSR1 (Gene ID: 9943) share the OSR1 symbol/alias in common. OSR1 is a widely used alternative name for oxidative stress responsive 1 (OXSR1). [29 Jun 2018]
Expression
Ubiquitous expression in esophagus (RPKM 13.6), bone marrow (RPKM 11.2) and 25 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See OXSR1 in Genome Data Viewer
Location:
3p22.2
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (38164063..38255484)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (38170735..38261199)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (38207028..38296975)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene DLEC1 cilia and flagella associated protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:38179733-38180676 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19680 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19681 Neighboring gene acetyl-CoA acyltransferase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:38196601-38197102 Neighboring gene uncharacterized LOC101928234 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:38205703-38206902 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:38207186-38207801 Neighboring gene MYD88 innate immune signal transduction adaptor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14207 Neighboring gene Sharpr-MPRA regulatory region 12810 Neighboring gene Sharpr-MPRA regulatory region 5010 Neighboring gene solute carrier family 22 member 13 Neighboring gene CDC42 pseudogene 7 Neighboring gene solute carrier family 22 member 14 Neighboring gene RNA, U6 small nuclear 235, pseudogene

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3. Tamari M, et al. J Hum Genet, 1999. PMID 10083736
  2. Structural and biochemical insights into the activation mechanisms of germinal center kinase OSR1. Li C, et al. J Biol Chem, 2014 Dec 26. PMID 25389294, Free PMC Article
  3. Sequence specific assignment and determination of OSR1 C-terminal domain structure by NMR. AlAmri MA, et al. Biochem Biophys Res Commun, 2019 Apr 30. PMID 30894278
  4. Association of OSR-1 With Vascular Dysfunction and Hypertension in Polycystic Kidney Disease. Kocyigit I, et al. Ther Apher Dial, 2020 Feb. PMID 31020807
  5. Crystal structure of domain-swapped STE20 OSR1 kinase domain. Lee SJ, et al. Protein Sci, 2009 Feb. PMID 19177573, Free PMC Article

See all (115) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association of genetic variants of oxidative stress responsive kinase 1 (OXSR1) with asthma exacerbations in non-smoking asthmatics.
    Title: Association of genetic variants of oxidative stress responsive kinase 1 (OXSR1) with asthma exacerbations in non-smoking asthmatics.
  2. Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains.
    Title: Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains.
  3. The Cul4-DDB1-WDR3/WDR6 Complex Binds SPAK and OSR1 Kinases in a Phosphorylation-Dependent Manner.
    Title: The Cul4-DDB1-WDR3/WDR6 Complex Binds SPAK and OSR1 Kinases in a Phosphorylation-Dependent Manner.
  4. SPAK and OSR1 kinases bind and phosphorylate the beta2-Adrenergic receptor.
    Title: SPAK and OSR1 kinases bind and phosphorylate the β(2)-Adrenergic receptor.
  5. High expression of OSR1 as a predictive biomarker for poor prognosis and lymph node metastasis in breast cancer.
    Title: High expression of OSR1 as a predictive biomarker for poor prognosis and lymph node metastasis in breast cancer.
  6. Regulation of ClC-2 activity by SPAK and OSR1.
    Title: Regulation of ClC-2 activity by SPAK and OSR1.
  7. WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells.
    Title: WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells.
  8. SPAK and OSR1 Sensitive Cell Membrane Protein Abundance and Activity of KCNQ1/E1 K+ Channels.
    Title: SPAK and OSR1 Sensitive Cell Membrane Protein Abundance and Activity of KCNQ1/E1 K+ Channels.
  9. Negative regulation of the creatine transporter SLC6A8 by SPAK and OSR1.
    Title: Negative regulation of the creatine transporter SLC6A8 by SPAK and OSR1.
  10. Downregulation of peptide transporters PEPT1 and PEPT2 by oxidative stress responsive kinase OSR1.
    Title: Downregulation of peptide transporters PEPT1 and PEPT2 by oxidative stress responsive kinase OSR1.
Submit: New GeneRIF Correction See all GeneRIFs (37)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA1101

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ion channel regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel inhibitor activity IDA
Inferred from Direct Assay
more info
  
enables potassium channel inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
  
Process Evidence Code Pubs
involved_in cell volume homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell volume homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular hyperosmotic response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular hyperosmotic response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular hyperosmotic response IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular hypotonic response IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to chemokine IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to chemokine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemokine (C-C motif) ligand 21 signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in chemokine (C-C motif) ligand 21 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in chemokine (C-X-C motif) ligand 12 signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in chemokine (C-X-C motif) ligand 12 signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in osmosensory signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of T cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of T cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in renal sodium ion absorption IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in renal sodium ion absorption IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxidative stress TAS
Traceable Author Statement
more info
 PubMed 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in extracellular exosome HDA PubMed 
Preferred Names
serine/threonine-protein kinase OSR1
Names
oxidative stress responsive 1
oxidative stress-responsive 1 protein
NP_005100.1
XP_011532633.1
XP_016863090.1
XP_024309619.1
XP_024309620.1
XP_047305342.1
XP_047305343.1
XP_047305344.1
XP_054204650.1
XP_054204651.1
XP_054204652.1
XP_054204653.1
XP_054204654.1
XP_054204655.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005109.3 → NP_005100.1  serine/threonine-protein kinase OSR1

    See identical proteins and their annotated locations for NP_005100.1

    Status: REVIEWED

    Source sequence(s)
    AB017642, BC008726
    Consensus CDS
    CCDS2675.1
    UniProtKB/Swiss-Prot
    O95747, Q3LR53, Q7Z501, Q9UPQ1
    UniProtKB/TrEMBL
    C9JIG9
    Related
    ENSP00000311713.3, ENST00000311806.8
    Conserved Domains (2) summary
    smart00220
    Location:17 → 291
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06610
    Location:15 → 291
    STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    38164063..38255484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534331.3 → XP_011532633.1  serine/threonine-protein kinase OSR1 isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:77 → 344
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06610
    Location:77 → 344
    STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

  2. XM_017007601.2 → XP_016863090.1  serine/threonine-protein kinase OSR1 isoform X2

  3. XM_024453851.2 → XP_024309619.1  serine/threonine-protein kinase OSR1 isoform X6

    Conserved Domains (1) summary
    cd06610
    Location:77 → 344
    STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

  4. XM_047449386.1 → XP_047305342.1  serine/threonine-protein kinase OSR1 isoform X3

    UniProtKB/TrEMBL
    C9JIG9
    Related
    ENSP00000525402.1, ENST00000855343.1

  5. XM_047449387.1 → XP_047305343.1  serine/threonine-protein kinase OSR1 isoform X4

  6. XM_047449388.1 → XP_047305344.1  serine/threonine-protein kinase OSR1 isoform X5

  7. XM_024453852.2 → XP_024309620.1  serine/threonine-protein kinase OSR1 isoform X7

    Conserved Domains (3) summary
    COG0515
    Location:1 → 204
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    pfam12202
    Location:242 → 273
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    cl21453
    Location:1 → 99
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_007095781.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    38170735..38261199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348675.1 → XP_054204650.1  serine/threonine-protein kinase OSR1 isoform X1

  2. XM_054348676.1 → XP_054204651.1  serine/threonine-protein kinase OSR1 isoform X2

  3. XM_054348677.1 → XP_054204652.1  serine/threonine-protein kinase OSR1 isoform X3

    UniProtKB/TrEMBL
    C9JIG9

  4. XM_054348678.1 → XP_054204653.1  serine/threonine-protein kinase OSR1 isoform X4

  5. XM_054348679.1 → XP_054204654.1  serine/threonine-protein kinase OSR1 isoform X5

  6. XM_054348680.1 → XP_054204655.1  serine/threonine-protein kinase OSR1 isoform X7

RNA

  1. XR_008486879.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95747.1 GenPept UniProtKB/Swiss-Prot:O95747

Gene LinkOut

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Chemical Information
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