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EXOG exo/endonuclease G [ Homo sapiens (human) ]

Gene ID: 9941, updated on 2-Mar-2021

Summary

Official Symbol
EXOGprovided by HGNC
Official Full Name
exo/endonuclease Gprovided by HGNC
Primary source
HGNC:HGNC:3347
See related
Ensembl:ENSG00000157036 MIM:604051
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ENGL; ENGLA; ENGLB; ENGL-a; ENGL-b; ENDOGL1; ENDOGL2
Summary
This gene encodes an endo/exonuclease with 5'-3' exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5' end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18. [provided by RefSeq, Feb 2009]
Expression
Ubiquitous expression in heart (RPKM 2.2), lymph node (RPKM 1.6) and 25 other tissues See more
Orthologs
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Genomic context

See EXOG in Genome Data Viewer
Location:
3p22.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (38496127..38526304)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (38537831..38567794)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene xylulokinase Neighboring gene ACVR2B antisense RNA 1 Neighboring gene activin A receptor type 2B Neighboring gene VISTA enhancer hs2266 Neighboring gene D-dopachrome tautomerase pseudogene 1 Neighboring gene ribosomal protein L18a pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic determinants of P wave duration and PR segment.
GeneReviews: Not available
Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC125944, MGC125945

Gene Ontology Provided by GOA

Function Evidence Code Pubs
5'-3' exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
5'-3' exonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
endonuclease activity NAS
Non-traceable Author Statement
more info
PubMed 
endoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
single-stranded DNA endodeoxyribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
apoptotic DNA fragmentation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nuclease EXOG, mitochondrial
Names
endo G-like 1
endo/exonuclease (5'-3'), endonuclease G-like
endonuclease G-like 1
endonuclease G-like 2
NP_001138936.1
NP_005098.2
XP_005265692.1
XP_006713505.1
XP_016863073.1
XP_016863074.1
XP_016863075.1
XP_016863076.1
XP_016863077.1
XP_016863078.1
XP_016863079.1
XP_016863080.1
XP_016863081.1
XP_016863082.1
XP_016863083.1
XP_024309615.1
XP_024309616.1
XP_024309617.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145464.2NP_001138936.1  nuclease EXOG, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_001138936.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AA993872, AB020523, AK290107, AK301067, AP006241
    Consensus CDS
    CCDS46795.1
    UniProtKB/Swiss-Prot
    Q9Y2C4
    Related
    ENSP00000404305.2, ENST00000422077.6
    Conserved Domains (1) summary
    smart00477
    Location:48236
    NUC; DNA/RNA non-specific endonuclease
  2. NM_005107.4NP_005098.2  nuclease EXOG, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_005098.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA993872, AB020523, AK290107, AK301067, AP006241
    Consensus CDS
    CCDS2680.1
    UniProtKB/Swiss-Prot
    Q9Y2C4
    Related
    ENSP00000287675.5, ENST00000287675.10
    Conserved Domains (1) summary
    smart00477
    Location:77286
    NUC; DNA/RNA non-specific endonuclease

RNA

  1. NR_134938.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK290107, AK308814, AP006241, W58006
  2. NR_153322.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP006241
  3. NR_153323.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP006241
  4. NR_153324.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP006241
  5. NR_153325.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP006241
  6. NR_153326.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP006241
  7. NR_153327.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP006241
  8. NR_153328.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP006241
  9. NR_153329.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP006241
  10. NR_153330.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP006241

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    38496127..38526304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007589.1XP_016863078.1  nuclease EXOG, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q9Y2C4
    Conserved Domains (1) summary
    smart00477
    Location:1146
    NUC; DNA/RNA non-specific endonuclease
  2. XM_017007588.1XP_016863077.1  nuclease EXOG, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q9Y2C4
    Conserved Domains (1) summary
    smart00477
    Location:1146
    NUC; DNA/RNA non-specific endonuclease
  3. XM_006713442.3XP_006713505.1  nuclease EXOG, mitochondrial isoform X1

    Conserved Domains (1) summary
    smart00477
    Location:1183
    NUC; DNA/RNA non-specific endonuclease
  4. XM_005265635.3XP_005265692.1  nuclease EXOG, mitochondrial isoform X3

    Related
    ENSP00000397124.1, ENST00000453767.1
    Conserved Domains (1) summary
    smart00477
    Location:77217
    NUC; DNA/RNA non-specific endonuclease
  5. XM_017007584.1XP_016863073.1  nuclease EXOG, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q9Y2C4
    Conserved Domains (1) summary
    smart00477
    Location:1146
    NUC; DNA/RNA non-specific endonuclease
  6. XM_017007585.1XP_016863074.1  nuclease EXOG, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q9Y2C4
    Conserved Domains (1) summary
    smart00477
    Location:1146
    NUC; DNA/RNA non-specific endonuclease
  7. XM_017007586.1XP_016863075.1  nuclease EXOG, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q9Y2C4
    Conserved Domains (1) summary
    smart00477
    Location:1146
    NUC; DNA/RNA non-specific endonuclease
  8. XM_017007587.1XP_016863076.1  nuclease EXOG, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q9Y2C4
    Conserved Domains (1) summary
    smart00477
    Location:1146
    NUC; DNA/RNA non-specific endonuclease
  9. XM_017007592.1XP_016863081.1  nuclease EXOG, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q9Y2C4
    Conserved Domains (1) summary
    smart00477
    Location:1146
    NUC; DNA/RNA non-specific endonuclease
  10. XM_017007591.1XP_016863080.1  nuclease EXOG, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q9Y2C4
    Conserved Domains (1) summary
    smart00477
    Location:1146
    NUC; DNA/RNA non-specific endonuclease
  11. XM_017007593.1XP_016863082.1  nuclease EXOG, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q9Y2C4
    Conserved Domains (1) summary
    smart00477
    Location:1146
    NUC; DNA/RNA non-specific endonuclease
  12. XM_017007590.1XP_016863079.1  nuclease EXOG, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q9Y2C4
    Conserved Domains (1) summary
    smart00477
    Location:1146
    NUC; DNA/RNA non-specific endonuclease
  13. XM_024453847.1XP_024309615.1  nuclease EXOG, mitochondrial isoform X2

    Conserved Domains (1) summary
    smart00477
    Location:1146
    NUC; DNA/RNA non-specific endonuclease
  14. XM_024453848.1XP_024309616.1  nuclease EXOG, mitochondrial isoform X2

    Conserved Domains (1) summary
    smart00477
    Location:1146
    NUC; DNA/RNA non-specific endonuclease
  15. XM_024453849.1XP_024309617.1  nuclease EXOG, mitochondrial isoform X2

    Conserved Domains (1) summary
    smart00477
    Location:1146
    NUC; DNA/RNA non-specific endonuclease
  16. XM_017007594.2XP_016863083.1  nuclease EXOG, mitochondrial isoform X4

RNA

  1. XR_940530.3 RNA Sequence

  2. XR_940529.3 RNA Sequence

  3. XR_940528.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001318954.1: Suppressed sequence

    Description
    NM_001318954.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
  2. NM_001318955.1: Suppressed sequence

    Description
    NM_001318955.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
  3. NM_001318956.1: Suppressed sequence

    Description
    NM_001318956.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
  4. NM_001318957.1: Suppressed sequence

    Description
    NM_001318957.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
  5. NM_001318958.1: Suppressed sequence

    Description
    NM_001318958.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
  6. NM_001318959.1: Suppressed sequence

    Description
    NM_001318959.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
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