Format

Send to:

Choose Destination

ARHGAP25 Rho GTPase activating protein 25 [ Homo sapiens (human) ]

Gene ID: 9938, updated on 24-Nov-2020

Summary

Official Symbol
ARHGAP25provided by HGNC
Official Full Name
Rho GTPase activating protein 25provided by HGNC
Primary source
HGNC:HGNC:28951
See related
Ensembl:ENSG00000163219 MIM:610587
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KAIA0053; HEL-S-308
Summary
ARHGAPs, such as ARHGAP25, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in lymph node (RPKM 20.1), spleen (RPKM 18.9) and 23 other tissues See more
Orthologs

Genomic context

See ARHGAP25 in Genome Data Viewer
Location:
2p13.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (68710510..68826845)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (68961913..69053965)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene transmembrane and coiled-coil domain family 1 pseudogene Neighboring gene prokineticin receptor 1 Neighboring gene Sharpr-MPRA regulatory region 5025 Neighboring gene uncharacterized LOC105374790 Neighboring gene CRISPRi-validated cis-regulatory element chr2.2482 Neighboring gene long intergenic non-protein coding RNA 1890 Neighboring gene long intergenic non-protein coding RNA 1888

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of small GTPase mediated signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
phagocytosis, engulfment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
phagocytic cup IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagocytic cup IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
rho GTPase-activating protein 25
Names
epididymis secretory protein Li 308
epididymis secretory sperm binding protein
rho-type GTPase-activating protein 25

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007231.3NP_001007232.2  rho GTPase-activating protein 25 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC097495, AK290396, BC032222, CD695161
    Consensus CDS
    CCDS33214.2
    UniProtKB/Swiss-Prot
    P42331
    Related
    ENSP00000386911.3, ENST00000409202.8
    Conserved Domains (3) summary
    cd04390
    Location:156354
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13263
    Location:45157
    PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain
    pfam00169
    Location:47149
    PH; PH domain
  2. NM_001166276.2NP_001159748.1  rho GTPase-activating protein 25 isoform c

    See identical proteins and their annotated locations for NP_001159748.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    BC032222
    Consensus CDS
    CCDS54364.1
    UniProtKB/Swiss-Prot
    P42331
    Related
    ENSP00000386241.1, ENST00000409220.5
    Conserved Domains (3) summary
    cd04390
    Location:149347
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13263
    Location:38150
    PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain
    pfam00169
    Location:40142
    PH; PH domain
  3. NM_001166277.2NP_001159749.1  rho GTPase-activating protein 25 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site and lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (d) that is shorter than isoform a.
    Source sequence(s)
    AC097495, AK297056, BC032222, CD695161
    Consensus CDS
    CCDS54363.1
    UniProtKB/Swiss-Prot
    P42331
    Related
    ENSP00000420583.1, ENST00000467265.5
    Conserved Domains (3) summary
    cd04390
    Location:117314
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    pfam00169
    Location:47115
    PH; PH domain
    cl17171
    Location:45120
    PH-like; Pleckstrin homology-like domain
  4. NM_001364819.1NP_001351748.1  rho GTPase-activating protein 25 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC097495, AK290396, BC032222, CD695161, DA462915
    Conserved Domains (3) summary
    cd04390
    Location:155353
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13263
    Location:45155
    PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain
    cl25732
    Location:544644
    SMC_N; RecF/RecN/SMC N terminal domain
  5. NM_001364820.1NP_001351749.1  rho GTPase-activating protein 25 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC097495, AK297056, BC032222, BX340497, CD695161
    Conserved Domains (3) summary
    cd04390
    Location:117315
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cl17171
    Location:45122
    PH-like; Pleckstrin homology-like domain
    cl25732
    Location:506606
    SMC_N; RecF/RecN/SMC N terminal domain
  6. NM_001364821.1NP_001351750.1  rho GTPase-activating protein 25 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC097495, AK297056, BC032222, CR991724, DB243756
    Conserved Domains (3) summary
    cd04390
    Location:130328
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13263
    Location:19131
    PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain
    cl25732
    Location:519619
    SMC_N; RecF/RecN/SMC N terminal domain
  7. NM_014882.3NP_055697.1  rho GTPase-activating protein 25 isoform b

    See identical proteins and their annotated locations for NP_055697.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    BC032222, D29642
    Consensus CDS
    CCDS46312.1
    UniProtKB/Swiss-Prot
    P42331
    UniProtKB/TrEMBL
    V9HWC8
    Related
    ENSP00000386863.3, ENST00000409030.7
    Conserved Domains (3) summary
    cd04390
    Location:148346
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13263
    Location:38148
    PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain
    pfam00169
    Location:40142
    PH; PH domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    68710510..68826845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533207.3XP_011531509.1  rho GTPase-activating protein 25 isoform X4

    See identical proteins and their annotated locations for XP_011531509.1

    Conserved Domains (3) summary
    cd04390
    Location:130328
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13263
    Location:19131
    PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain
    cl25732
    Location:519619
    SMC_N; RecF/RecN/SMC N terminal domain
  2. XM_011533208.2XP_011531510.1  rho GTPase-activating protein 25 isoform X4

    See identical proteins and their annotated locations for XP_011531510.1

    Conserved Domains (3) summary
    cd04390
    Location:130328
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13263
    Location:19131
    PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain
    cl25732
    Location:519619
    SMC_N; RecF/RecN/SMC N terminal domain
  3. XM_017005423.2XP_016860912.1  rho GTPase-activating protein 25 isoform X1

  4. XM_017005424.1XP_016860913.1  rho GTPase-activating protein 25 isoform X2

  5. XM_017005425.1XP_016860914.1  rho GTPase-activating protein 25 isoform X5

  6. XM_017005428.1XP_016860917.1  rho GTPase-activating protein 25 isoform X9

    Related
    ENSP00000417283.1, ENST00000463483.5
  7. XM_011533209.2XP_011531511.1  rho GTPase-activating protein 25 isoform X7

    Related
    ENSP00000417818.1, ENST00000497259.5
    Conserved Domains (1) summary
    cd04390
    Location:38236
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
  8. XM_017005426.1XP_016860915.1  rho GTPase-activating protein 25 isoform X8

    Conserved Domains (1) summary
    cl02570
    Location:180
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
  9. XM_017005427.1XP_016860916.1  rho GTPase-activating protein 25 isoform X8

    Conserved Domains (1) summary
    cl02570
    Location:180
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
  10. XM_011533210.3XP_011531512.1  rho GTPase-activating protein 25 isoform X8

    Related
    ENSP00000417467.1, ENST00000479844.1
    Conserved Domains (1) summary
    cl02570
    Location:180
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
Support Center