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Cul4a cullin 4A [ Mus musculus (house mouse) ]

Gene ID: 99375, updated on 26-Sep-2022

Summary

Official Symbol
Cul4aprovided by MGI
Official Full Name
cullin 4Aprovided by MGI
Primary source
MGI:MGI:1914487
See related
Ensembl:ENSMUSG00000031446 AllianceGenome:MGI:1914487
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810470J21Rik
Summary
Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-protein transferase activity. Involved in in utero embryonic development and ribosome biogenesis. Acts upstream of or within several processes, including negative regulation of granulocyte differentiation; positive regulation of G1/S transition of mitotic cell cycle; and regulation of response to DNA damage stimulus. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and musculoskeletal system. Orthologous to human CUL4A (cullin 4A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 25.1), adrenal adult (RPKM 24.4) and 28 other tissues See more
Orthologs
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Genomic context

See Cul4a in Genome Data Viewer
Location:
8; 8 A1.1
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13155623..13197940)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13105623..13147940)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene coagulation factor X Neighboring gene protein Z, vitamin K-dependent plasma glycoprotein Neighboring gene PCI domain containing 2 Neighboring gene microRNA 7065 Neighboring gene lysosomal-associated membrane protein 1 Neighboring gene GH regulated TBC protein 1 Neighboring gene microRNA 1968

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC36573

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to DNA damage stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to DNA damage stimulus IC
Inferred by Curator
more info
PubMed 
involved_in cellular response to UV IC
Inferred by Curator
more info
PubMed 
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of granulocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of protein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
involved_in ribosome biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribosome biogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Cul4-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
part_of Cul4A-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Cul4A-RING E3 ubiquitin ligase complex IC
Inferred by Curator
more info
PubMed 
part_of Cul4A-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
part_of cullin-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IC
Inferred by Curator
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363448.1NP_001350377.1  cullin-4A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment of two consecutive exons compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC133520
    Conserved Domains (2) summary
    smart00884
    Location:630695
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:89601
    Cullin; Cullin family
  2. NM_001363450.1NP_001350379.1  cullin-4A isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC133520
    Conserved Domains (2) summary
    smart00884
    Location:543608
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:1514
    Cullin; Cullin family
  3. NM_146207.3NP_666319.2  cullin-4A isoform 1

    See identical proteins and their annotated locations for NP_666319.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC133520
    Consensus CDS
    CCDS52485.1
    UniProtKB/Swiss-Prot
    Q3TCH7, Q91Z44
    UniProtKB/TrEMBL
    A0A8C6GKD6
    Related
    ENSMUSP00000016680.8, ENSMUST00000016680.14
    Conserved Domains (3) summary
    smart00182
    Location:442582
    CULLIN; Cullin
    smart00884
    Location:688753
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:65659
    Cullin; Cullin family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    13155623..13197940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)