Format

Send to:

Choose Destination

KIF14 kinesin family member 14 [ Homo sapiens (human) ]

Gene ID: 9928, updated on 12-Oct-2019

Summary

Official Symbol
KIF14provided by HGNC
Official Full Name
kinesin family member 14provided by HGNC
Primary source
HGNC:HGNC:19181
See related
Ensembl:ENSG00000118193 MIM:611279
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MKS12; MCPH20
Summary
This gene encodes a member of the kinesin-3 superfamily of microtubule motor proteins. These proteins are involved in numerous processes including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. In human HeLa-S3 and 293T cells, this protein is localized to the cytoplasm during interphase, to the spindle poles and spindle microtubules during mitosis, and to the midbody during cytokinesis. An internal motor domain displays microtubule-dependent ATPase activity, consistent with its function as a microtubule motor protein. Knockdown of this gene results in failed cytokinesis with endoreplication, which results in multinucleated cells. This gene has been identified as a likely oncogene in breast, lung and ovarian cancers, as well as retinoblastomas and gliomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Expression
Broad expression in bone marrow (RPKM 2.3), lymph node (RPKM 1.7) and 14 other tissues See more
Orthologs

Genomic context

See KIF14 in Genome Data Viewer
Location:
1q32.1
Exon count:
32
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (200551497..200620791, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (200520625..200589862, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 281 Neighboring gene uncharacterized LOC107985459 Neighboring gene DEAD-box helicase 59 Neighboring gene DDX59 antisense RNA 1 Neighboring gene calmodulin regulated spectrin associated protein family member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
  • RHO GTPases activate CIT, organism-specific biosystem (from REACTOME)
    RHO GTPases activate CIT, organism-specific biosystemCitron kinase (CIT) or citron RHO-interacting kinase (CRIK) shares similarities with ROCK kinases. Like ROCK, it consists of a serine/threonine kinase domain, a coiled-coil region, a RHO-binding doma...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0042, MGC142302

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
ATP-dependent microtubule motor activity, plus-end-directed ISS
Inferred from Sequence or Structural Similarity
more info
 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
PDZ domain binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
cell proliferation in forebrain ISS
Inferred from Sequence or Structural Similarity
more info
 
cerebellar Purkinje cell layer structural organization ISS
Inferred from Sequence or Structural Similarity
more info
 
cerebellar cortex development ISS
Inferred from Sequence or Structural Similarity
more info
 
cerebellar granular layer structural organization ISS
Inferred from Sequence or Structural Similarity
more info
 
cerebral cortex development ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeleton-dependent intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment of protein localization IDA
Inferred from Direct Assay
more info
PubMed 
hippocampus development ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT microtubule depolymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic metaphase plate congression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of integrin activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
olfactory bulb development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of Rap protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell maturation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of myelination ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Flemming body IDA
Inferred from Direct Assay
more info
 
cell IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with plasma membrane IPI
Inferred from Physical Interaction
more info
PubMed 
spindle midzone IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
kinesin-like protein KIF14
Names
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042074.1 RefSeqGene

    Range
    4984..74235
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001305792.1NP_001292721.1  kinesin-like protein KIF14 isoform 2

    See identical proteins and their annotated locations for NP_001292721.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an exon in the 5' coding region, which results in use of a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AL445483, BC098582, BC113742, BC144068, BE644769, BQ425495, CN307042, CR748178, D26361
    UniProtKB/Swiss-Prot
    Q15058
    Conserved Domains (5) summary
    smart00129
    Location:1217
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:312409
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl22853
    Location:1217
    Motor_domain; Myosin and Kinesin motor domain
    pfam11068
    Location:471531
    YlqD; YlqD protein
    pfam16183
    Location:214332
    Kinesin_assoc; Kinesin-associated
  2. NM_014875.3NP_055690.1  kinesin-like protein KIF14 isoform 1

    See identical proteins and their annotated locations for NP_055690.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL445483, BC098582, D26361
    Consensus CDS
    CCDS30963.1
    UniProtKB/Swiss-Prot
    Q15058
    Related
    ENSP00000356319.4, ENST00000367350.5
    Conserved Domains (5) summary
    smart00129
    Location:358708
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:803900
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:357708
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam11068
    Location:9621022
    YlqD; YlqD protein
    pfam16183
    Location:705823
    Kinesin_assoc; Kinesin-associated

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    200551497..200620791 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510236.1XP_011508538.1  kinesin-like protein KIF14 isoform X6

    See identical proteins and their annotated locations for XP_011508538.1

    Conserved Domains (5) summary
    smart00129
    Location:1217
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:312409
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl22853
    Location:1217
    Motor_domain; Myosin and Kinesin motor domain
    pfam11068
    Location:471531
    YlqD; YlqD protein
    pfam16183
    Location:214332
    Kinesin_assoc; Kinesin-associated
  2. XM_011510232.2XP_011508534.1  kinesin-like protein KIF14 isoform X1

    See identical proteins and their annotated locations for XP_011508534.1

    UniProtKB/Swiss-Prot
    Q15058
    Conserved Domains (5) summary
    smart00129
    Location:358708
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:803900
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:357708
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam11068
    Location:9621022
    YlqD; YlqD protein
    pfam16183
    Location:705823
    Kinesin_assoc; Kinesin-associated
  3. XM_017003007.1XP_016858496.1  kinesin-like protein KIF14 isoform X5

  4. XM_017003006.1XP_016858495.1  kinesin-like protein KIF14 isoform X3

  5. XM_011510235.2XP_011508537.1  kinesin-like protein KIF14 isoform X4

    Conserved Domains (5) summary
    smart00129
    Location:234584
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:679776
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:233584
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam11068
    Location:838898
    YlqD; YlqD protein
    pfam16183
    Location:581699
    Kinesin_assoc; Kinesin-associated
  6. XM_011510233.2XP_011508535.1  kinesin-like protein KIF14 isoform X2

    Conserved Domains (5) summary
    smart00129
    Location:330680
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:775872
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:329680
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam11068
    Location:934994
    YlqD; YlqD protein
    pfam16183
    Location:677795
    Kinesin_assoc; Kinesin-associated
  7. XM_011510231.2XP_011508533.1  kinesin-like protein KIF14 isoform X1

    See identical proteins and their annotated locations for XP_011508533.1

    UniProtKB/Swiss-Prot
    Q15058
    Conserved Domains (5) summary
    smart00129
    Location:358708
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:803900
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:357708
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam11068
    Location:9621022
    YlqD; YlqD protein
    pfam16183
    Location:705823
    Kinesin_assoc; Kinesin-associated
  8. XM_017003005.1XP_016858494.1  kinesin-like protein KIF14 isoform X1

    UniProtKB/Swiss-Prot
    Q15058
    Related
    ENSP00000483069.1, ENST00000614960.4
    Conserved Domains (5) summary
    smart00129
    Location:358708
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:803900
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:357708
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam11068
    Location:9621022
    YlqD; YlqD protein
    pfam16183
    Location:705823
    Kinesin_assoc; Kinesin-associated
Support Center