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KIF14 kinesin family member 14 [ Homo sapiens (human) ]

Gene ID: 9928, updated on 5-Aug-2022

Summary

Official Symbol
KIF14provided by HGNC
Official Full Name
kinesin family member 14provided by HGNC
Primary source
HGNC:HGNC:19181
See related
Ensembl:ENSG00000118193 MIM:611279; AllianceGenome:HGNC:19181
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MKS12; MCPH20
Summary
This gene encodes a member of the kinesin-3 superfamily of microtubule motor proteins. These proteins are involved in numerous processes including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. In human HeLa-S3 and 293T cells, this protein is localized to the cytoplasm during interphase, to the spindle poles and spindle microtubules during mitosis, and to the midbody during cytokinesis. An internal motor domain displays microtubule-dependent ATPase activity, consistent with its function as a microtubule motor protein. Knockdown of this gene results in failed cytokinesis with endoreplication, which results in multinucleated cells. This gene has been identified as a likely oncogene in breast, lung and ovarian cancers, as well as retinoblastomas and gliomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Expression
Broad expression in bone marrow (RPKM 2.3), lymph node (RPKM 1.7) and 14 other tissues See more
Orthologs
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Genomic context

See KIF14 in Genome Data Viewer
Location:
1q32.1
Exon count:
32
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (200551497..200620751, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (199808434..199877674, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (200520625..200589879, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900414 Neighboring gene uncharacterized LOC124904480 Neighboring gene uncharacterized LOC107985459 Neighboring gene DEAD-box helicase 59 Neighboring gene DDX59 antisense RNA 1 Neighboring gene calmodulin regulated spectrin associated protein family member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0042, MGC142302

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP hydrolysis activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables PDZ domain binding IDA
Inferred from Direct Assay
more info
PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables plus-end-directed microtubule motor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in activation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cell proliferation in forebrain ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cerebellar Purkinje cell layer structural organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cerebellar cortex development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cerebellar granular layer structural organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cerebral cortex development ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within establishment of protein localization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hippocampus development ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT involved_in microtubule depolymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic metaphase plate congression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of integrin activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in olfactory bulb development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of Rap protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell maturation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of myelination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Flemming body IDA
Inferred from Direct Assay
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane HDA PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with plasma membrane IPI
Inferred from Physical Interaction
more info
PubMed 
located_in spindle midzone IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
kinesin-like protein KIF14
Names
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042074.1 RefSeqGene

    Range
    4984..74235
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001305792.1NP_001292721.1  kinesin-like protein KIF14 isoform 2

    See identical proteins and their annotated locations for NP_001292721.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an exon in the 5' coding region, which results in use of a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AL445483, BC098582, BC113742, BC144068, BE644769, BQ425495, CN307042, CR748178, D26361
    UniProtKB/Swiss-Prot
    Q15058
    Conserved Domains (5) summary
    smart00129
    Location:1217
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:312409
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl22853
    Location:1217
    Motor_domain; Myosin and Kinesin motor domain
    pfam11068
    Location:471531
    YlqD; YlqD protein
    pfam16183
    Location:214332
    Kinesin_assoc; Kinesin-associated
  2. NM_014875.3NP_055690.1  kinesin-like protein KIF14 isoform 1

    See identical proteins and their annotated locations for NP_055690.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL445483, BC098582, D26361
    Consensus CDS
    CCDS30963.1
    UniProtKB/Swiss-Prot
    Q15058, Q5T1W3
    Related
    ENSP00000356319.4, ENST00000367350.5
    Conserved Domains (5) summary
    smart00129
    Location:358708
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:803900
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:357708
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam11068
    Location:9621022
    YlqD; YlqD protein
    pfam16183
    Location:705823
    Kinesin_assoc; Kinesin-associated

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    200551497..200620751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047436198.1XP_047292154.1  kinesin-like protein KIF14 isoform X5

  2. XM_047436190.1XP_047292146.1  kinesin-like protein KIF14 isoform X2

  3. XM_011510232.3XP_011508534.1  kinesin-like protein KIF14 isoform X1

    See identical proteins and their annotated locations for XP_011508534.1

    UniProtKB/Swiss-Prot
    Q15058, Q5T1W3
    Related
    ENSP00000483069.1, ENST00000614960.4
    Conserved Domains (5) summary
    smart00129
    Location:358708
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:803900
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:357708
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam11068
    Location:9621022
    YlqD; YlqD protein
    pfam16183
    Location:705823
    Kinesin_assoc; Kinesin-associated
  4. XM_017003007.2XP_016858496.1  kinesin-like protein KIF14 isoform X7

    Conserved Domains (3) summary
    cd00060
    Location:614711
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    TIGR02168
    Location:733884
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01365
    Location:168519
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
  5. XM_047436199.1XP_047292155.1  kinesin-like protein KIF14 isoform X6

  6. XM_047436195.1XP_047292151.1  kinesin-like protein KIF14 isoform X4

  7. XM_017003006.2XP_016858495.1  kinesin-like protein KIF14 isoform X3

  8. XM_011510235.3XP_011508537.1  kinesin-like protein KIF14 isoform X5

    Conserved Domains (5) summary
    smart00129
    Location:234584
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:679776
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:233584
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam11068
    Location:838898
    YlqD; YlqD protein
    pfam16183
    Location:581699
    Kinesin_assoc; Kinesin-associated
  9. XM_011510233.3XP_011508535.1  kinesin-like protein KIF14 isoform X2

    Conserved Domains (5) summary
    smart00129
    Location:330680
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:775872
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:329680
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam11068
    Location:934994
    YlqD; YlqD protein
    pfam16183
    Location:677795
    Kinesin_assoc; Kinesin-associated
  10. XM_047436181.1XP_047292137.1  kinesin-like protein KIF14 isoform X2

  11. XM_011510231.3XP_011508533.1  kinesin-like protein KIF14 isoform X1

    See identical proteins and their annotated locations for XP_011508533.1

    UniProtKB/Swiss-Prot
    Q15058, Q5T1W3
    Conserved Domains (5) summary
    smart00129
    Location:358708
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:803900
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:357708
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam11068
    Location:9621022
    YlqD; YlqD protein
    pfam16183
    Location:705823
    Kinesin_assoc; Kinesin-associated
  12. XM_047436197.1XP_047292153.1  kinesin-like protein KIF14 isoform X5

  13. XM_047436184.1XP_047292140.1  kinesin-like protein KIF14 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    199808434..199877674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)