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LPGAT1 lysophosphatidylglycerol acyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 9926, updated on 10-Oct-2020

Summary

Official Symbol
LPGAT1provided by HGNC
Official Full Name
lysophosphatidylglycerol acyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:28985
See related
Ensembl:ENSG00000123684 MIM:610473
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NET8; FAM34A; FAM34A1
Summary
This gene encodes a member of the lysophospholipid acyltransferase family. The encoded protein catalyzes the reacylation of lysophosphatidylglycerol to phosphatidylglycerol, a membrane phospholipid that is an important precursor for the synthesis of cardiolipin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in small intestine (RPKM 15.0), thyroid (RPKM 14.6) and 25 other tissues See more
Orthologs

Genomic context

See LPGAT1 in Genome Data Viewer
Location:
1q32.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (211743457..211830763, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (211916799..212048531, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372904 Neighboring gene Sharpr-MPRA regulatory region 10839 Neighboring gene RNA, 7SL, cytoplasmic 344, pseudogene Neighboring gene LPGAT1 antisense RNA 1 Neighboring gene integrator complex subunit 7 Neighboring gene ribosomal protein L21 pseudogene 28 Neighboring gene denticleless E3 ubiquitin protein ligase homolog

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
transferase activity, transferring acyl groups IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
phosphatidylglycerol acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylinositol acyl-chain remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
acyl-CoA:lysophosphatidylglycerol acyltransferase 1
Names
family with sequence similarity 34, member A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320808.2NP_001307737.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC096637, AI264005, AL445488, BC034621, BP369253
    Consensus CDS
    CCDS31018.1
    UniProtKB/Swiss-Prot
    Q92604
    Related
    ENSP00000355963.1, ENST00000366996.1
    Conserved Domains (2) summary
    cd07990
    Location:69285
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:274343
    Acyltransf_C; Acyltransferase C-terminus
  2. NM_001375841.1NP_001362770.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC096637, AL445488
    Conserved Domains (2) summary
    cd07990
    Location:69285
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:274343
    Acyltransf_C; Acyltransferase C-terminus
  3. NM_001375842.1NP_001362771.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC096637, AL445488
    Conserved Domains (2) summary
    cd07990
    Location:69285
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:274343
    Acyltransf_C; Acyltransferase C-terminus
  4. NM_001375844.1NP_001362773.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC096637, AL445488
    Conserved Domains (2) summary
    cd07990
    Location:102318
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:307376
    Acyltransf_C; Acyltransferase C-terminus
  5. NM_001375845.1NP_001362774.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC096637, AL445488
    Conserved Domains (2) summary
    cd07990
    Location:102318
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:307376
    Acyltransf_C; Acyltransferase C-terminus
  6. NM_014873.3NP_055688.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_055688.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC096637, AI264005, D86960
    Consensus CDS
    CCDS31018.1
    UniProtKB/Swiss-Prot
    Q92604
    Related
    ENSP00000355964.4, ENST00000366997.9
    Conserved Domains (2) summary
    cd07990
    Location:69285
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:274343
    Acyltransf_C; Acyltransferase C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    211743457..211830763 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003004.1XP_016858493.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X3

  2. XM_011510229.3XP_011508531.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X2

    See identical proteins and their annotated locations for XP_011508531.1

    UniProtKB/Swiss-Prot
    Q92604
    Conserved Domains (2) summary
    cd07990
    Location:69285
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:274343
    Acyltransf_C; Acyltransferase C-terminus
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