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RNF10 ring finger protein 10 [ Homo sapiens (human) ]

Gene ID: 9921, updated on 5-Jul-2025
Official Symbol
RNF10provided by HGNC
Official Full Name
ring finger protein 10provided by HGNC
Primary source
HGNC:HGNC:10055
See related
Ensembl:ENSG00000022840 MIM:615998; AllianceGenome:HGNC:10055
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RIE2
Summary
The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 52.4), bone marrow (RPKM 51.8) and 25 other tissues See more
Orthologs
mouse all
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See RNF10 in Genome Data Viewer
Location:
12q24.31
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (120534356..120577588)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (120523536..120566717)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120972159..121015391)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene dynein light chain LC8-type 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4952 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:120933574-120934240 Neighboring gene negative regulator of antiviral response Neighboring gene coenzyme Q5, methyltransferase Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:120965951-120966721 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:120966722-120967491 Neighboring gene ribosomal protein L29 pseudogene 24 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120972057-120972210 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4954 Neighboring gene uncharacterized LOC128071547 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4956 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:121028475-121029374 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:121029375-121030273 Neighboring gene POP5 ribonuclease P/MRP subunit Neighboring gene ribosomal protein L11 pseudogene 5

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Reduced RING finger protein 10 expression in macrophages is associated with aging-related inflammation. Cao X, et al. FEBS Open Bio, 2021 Feb. PMID 33249776, Free PMC Article
  2. iRQC, a surveillance pathway for 40S ribosomal quality control during mRNA translation initiation. Garshott DM, et al. Cell Rep, 2021 Aug 31. PMID 34469731, Free PMC Article
  3. Whole exome sequencing identifies variation in CYB5A and RNF10 associated with adiposity and type 2 diabetes. Huang K, et al. Obesity (Silver Spring), 2014 Apr. PMID 24151200, Free PMC Article
  4. cDNA cloning, expression profile, and genomic structure of human and mouse RNF10/Rnf 10 genes, encoding a novel RING finger protein. Seki N, et al. J Hum Genet, 2000. PMID 10697961
  5. CircRNA RNF10 inhibits tumorigenicity by targeting miR-942-5p/GOLIM4 axis in breast cancer. Kan B, et al. Environ Mol Mutagen, 2022 Aug. PMID 36054164

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircRNA RNF10 inhibits tumorigenicity by targeting miR-942-5p/GOLIM4 axis in breast cancer.
    Title: CircRNA RNF10 inhibits tumorigenicity by targeting miR-942-5p/GOLIM4 axis in breast cancer.
  2. The E3 ubiquitin ligase RNF10 modifies 40S ribosomal subunits of ribosomes compromised in translation.
    Title: The E3 ubiquitin ligase RNF10 modifies 40S ribosomal subunits of ribosomes compromised in translation.
  3. Reduced RING finger protein 10 expression in macrophages is associated with aging-related inflammation.
    Title: Reduced RING finger protein 10 expression in macrophages is associated with aging-related inflammation.
  4. CYB5A, which has a role in stearyl-CoA-desaturase activity, and RNF10, with an unknown role in weight regulating pathways, associated with adiposity and nominally increased the risk for T2D in American Indians.
    Title: Whole exome sequencing identifies variation in CYB5A and RNF10 associated with adiposity and type 2 diabetes.
  5. RNF10 is a trans-acting protein regulating MAG expression and is required for myelin formation.
    Title: A novel function of RING finger protein 10 in transcriptional regulation of the myelin-associated glycoprotein gene and myelin formation in Schwann cells.
  6. MEOX2 and Meox2 binding to RNF10 protein was characterized.
    Title: Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
New susceptibility loci associated with kidney disease in type 1 diabetes.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Replication interactions

Interaction Pubs
Knockdown of ring finger protein 10 (RNF10) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0262, MGC126758, MGC126764

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of Schwann cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Schwann cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of myelination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of myelination IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of myelination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in postsynapse to nucleus signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein monoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome-associated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extrinsic component of postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
E3 ubiquitin-protein ligase RNF10
Names
epididymis secretory sperm binding protein
NP_001317403.1
NP_055683.3

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330474.2 → NP_001317403.1  E3 ubiquitin-protein ligase RNF10 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is longer, but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AB027196, BQ015862, BU184035, DA956437, HY376488
    Consensus CDS
    CCDS81746.1
    UniProtKB/TrEMBL
    B3KSN5, B3KUR9
    Related
    ENSP00000415682.2, ENST00000413266.6
    Conserved Domains (1) summary
    pfam13923
    Location:225 → 266
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

  2. NM_014868.5 → NP_055683.3  E3 ubiquitin-protein ligase RNF10 isoform 1

    See identical proteins and their annotated locations for NP_055683.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    BC016622, BQ015862, DA103961, DB526099
    Consensus CDS
    CCDS9201.1
    UniProtKB/Swiss-Prot
    Q8N5U6, Q92550, Q9NPP8, Q9ULW4
    UniProtKB/TrEMBL
    A0A024RBP0, B3KSN5, B3KUR9
    Related
    ENSP00000322242.4, ENST00000325954.9
    Conserved Domains (1) summary
    cd16536
    Location:225 → 267
    RING-HC_RNF10; RING finger, HC subclass, found in RING finger protein 10 (RNF10) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    120534356..120577588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    120523536..120566717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N5U6.2 GenPept UniProtKB/Swiss-Prot:Q8N5U6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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