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RNF10 ring finger protein 10 [ Homo sapiens (human) ]

Gene ID: 9921, updated on 3-May-2020

Summary

Official Symbol
RNF10provided by HGNC
Official Full Name
ring finger protein 10provided by HGNC
Primary source
HGNC:HGNC:10055
See related
Ensembl:ENSG00000022840 MIM:615998
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RIE2
Summary
The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 52.4), bone marrow (RPKM 51.8) and 25 other tissues See more
Orthologs

Genomic context

See RNF10 in Genome Data Viewer
Location:
12q24.31
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (120534353..120577588)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120972132..121015397)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene dynein light chain LC8-type 1 Neighboring gene uncharacterized LOC107987181 Neighboring gene negative regulator of antiviral response Neighboring gene coenzyme Q5, methyltransferase Neighboring gene ribosomal protein L29 pseudogene 24 Neighboring gene POP5 homolog, ribonuclease P/MRP subunit Neighboring gene ribosomal protein L11 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ring finger protein 10 (RNF10) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0262, MGC126758, MGC126764

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
negative regulation of Schwann cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of myelination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of myelination ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
protein autoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
RING finger protein 10
Names
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330474.2NP_001317403.1  RING finger protein 10 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is longer, but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AB027196, BQ015862, BU184035, DA956437, HY376488
    Consensus CDS
    CCDS81746.1
    UniProtKB/Swiss-Prot
    Q8N5U6
    Related
    ENSP00000415682.2, ENST00000413266.6
    Conserved Domains (1) summary
    pfam13923
    Location:225266
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
  2. NM_014868.5NP_055683.3  RING finger protein 10 isoform 1

    See identical proteins and their annotated locations for NP_055683.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    BC016622, BQ015862, DA103961, DB526099
    Consensus CDS
    CCDS9201.1
    UniProtKB/Swiss-Prot
    Q8N5U6
    UniProtKB/TrEMBL
    A0A024RBP0
    Related
    ENSP00000322242.4, ENST00000325954.9
    Conserved Domains (1) summary
    cd16536
    Location:225267
    RING-HC_RNF10; RING finger, HC subclass, found in RING finger protein 10 (RNF10) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    120534353..120577588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254013.2XP_005254070.1  RING finger protein 10 isoform X1

    Conserved Domains (1) summary
    pfam13923
    Location:175216
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
  2. XM_017020282.1XP_016875771.1  RING finger protein 10 isoform X2

    Conserved Domains (1) summary
    pfam13923
    Location:175216
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
  3. XM_017020283.2XP_016875772.1  RING finger protein 10 isoform X3

RNA

  1. XR_001748937.2 RNA Sequence

  2. XR_001748938.2 RNA Sequence

  3. XR_001748939.1 RNA Sequence

  4. XR_243026.4 RNA Sequence

  5. XR_001748935.2 RNA Sequence

  6. XR_001748936.2 RNA Sequence

  7. XR_944849.3 RNA Sequence

  8. XR_001748933.2 RNA Sequence

  9. XR_001748934.2 RNA Sequence

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