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Ssx2ip synovial sarcoma, X 2 interacting protein [ Mus musculus (house mouse) ]

Gene ID: 99167, updated on 4-Nov-2022

Summary

Official Symbol
Ssx2ipprovided by MGI
Official Full Name
synovial sarcoma, X 2 interacting proteinprovided by MGI
Primary source
MGI:MGI:2139150
See related
Ensembl:ENSMUSG00000036825 AllianceGenome:MGI:2139150
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adip
Summary
Predicted to enable protein domain specific binding activity. Acts upstream of or within regulation of Rac protein signal transduction and regulation of cell motility. Located in cell leading edge; centriolar satellite; and ciliary basal body. Orthologous to human SSX2IP (SSX family member 2 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 30.6), liver E14 (RPKM 23.9) and 20 other tissues See more
Orthologs
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Genomic context

See Ssx2ip in Genome Data Viewer
Location:
3; 3 H2
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (146110397..146145899)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (146404642..146440144)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10636 Neighboring gene predicted gene, 22078 Neighboring gene chitobiase Neighboring gene spermatogenesis associated 1 Neighboring gene G protein subunit gamma 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in centriolar satellite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
PubMed 
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
afadin- and alpha-actinin-binding protein
Names
afadin DIL domain-interacting protein
synovial sarcoma, X breakpoint 2 interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253768.2NP_001240697.1  afadin- and alpha-actinin-binding protein isoform b

    See identical proteins and their annotated locations for NP_001240697.1

    Status: VALIDATED

    Source sequence(s)
    AC124987, AK049080, AK077112, AK173064, BE945817
    Consensus CDS
    CCDS57260.1
    UniProtKB/Swiss-Prot
    Q8VC66
    UniProtKB/TrEMBL
    A0A0R4J1A9
    Related
    ENSMUSP00000101755.2, ENSMUST00000106149.8
    Conserved Domains (1) summary
    pfam11559
    Location:63214
    ADIP; Afadin- and alpha -actinin-Binding
  2. NM_001253769.2NP_001240698.1  afadin- and alpha-actinin-binding protein isoform b

    See identical proteins and their annotated locations for NP_001240698.1

    Status: VALIDATED

    Source sequence(s)
    AC124987, AK043865, AK049080, AK173064, BE945817
    Consensus CDS
    CCDS57260.1
    UniProtKB/Swiss-Prot
    Q8VC66
    UniProtKB/TrEMBL
    A0A0R4J1A9
    Related
    ENSMUSP00000101757.2, ENSMUST00000106151.8
    Conserved Domains (1) summary
    pfam11559
    Location:63214
    ADIP; Afadin- and alpha -actinin-Binding
  3. NM_001253770.2NP_001240699.1  afadin- and alpha-actinin-binding protein isoform b

    See identical proteins and their annotated locations for NP_001240699.1

    Status: VALIDATED

    Source sequence(s)
    AC124987, AK031356, AK049080, AK173064, BE945817
    Consensus CDS
    CCDS57260.1
    UniProtKB/Swiss-Prot
    Q8VC66
    UniProtKB/TrEMBL
    A0A0R4J1A9
    Related
    ENSMUSP00000045663.5, ENSMUST00000039021.11
    Conserved Domains (1) summary
    pfam11559
    Location:63214
    ADIP; Afadin- and alpha -actinin-Binding
  4. NM_001355661.1NP_001342590.1  afadin- and alpha-actinin-binding protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC124987
    Consensus CDS
    CCDS38665.1
    UniProtKB/Swiss-Prot
    Q8K2F7
    Conserved Domains (2) summary
    pfam11559
    Location:63214
    ADIP; Afadin- and alpha -actinin-Binding
    pfam17380
    Location:140301
    DUF5401; Family of unknown function (DUF5401)
  5. NM_001411104.1NP_001398033.1  afadin- and alpha-actinin-binding protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC124987
    UniProtKB/Swiss-Prot
    Q8K2F7
  6. NM_001411105.1NP_001398034.1  afadin- and alpha-actinin-binding protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC124987
    UniProtKB/Swiss-Prot
    Q8K2F7
  7. NM_001411107.1NP_001398036.1  afadin- and alpha-actinin-binding protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC124987
    UniProtKB/Swiss-Prot
    Q8K2F7
  8. NM_001411108.1NP_001398037.1  afadin- and alpha-actinin-binding protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC124987
    UniProtKB/Swiss-Prot
    Q8K2F7
  9. NM_001411109.1NP_001398038.1  afadin- and alpha-actinin-binding protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC124987
    UniProtKB/Swiss-Prot
    Q8K2F7
  10. NM_001411110.1NP_001398039.1  afadin- and alpha-actinin-binding protein isoform b

    Status: VALIDATED

    Source sequence(s)
    AC124987
    UniProtKB/TrEMBL
    A0A0R4J1A9
  11. NM_001411114.1NP_001398043.1  afadin- and alpha-actinin-binding protein isoform b

    Status: VALIDATED

    Source sequence(s)
    AC124987
    UniProtKB/TrEMBL
    A0A0R4J1A9
  12. NM_001411115.1NP_001398044.1  afadin- and alpha-actinin-binding protein isoform b

    Status: VALIDATED

    Source sequence(s)
    AC124987
    UniProtKB/TrEMBL
    A0A0R4J1A9
  13. NM_001411116.1NP_001398045.1  afadin- and alpha-actinin-binding protein isoform c

    Status: VALIDATED

    Source sequence(s)
    AC124987
  14. NM_001411117.1NP_001398046.1  afadin- and alpha-actinin-binding protein isoform c

    Status: VALIDATED

    Source sequence(s)
    AC124987
  15. NM_001411118.1NP_001398047.1  afadin- and alpha-actinin-binding protein isoform c

    Status: VALIDATED

    Source sequence(s)
    AC124987
  16. NM_001411119.1NP_001398048.1  afadin- and alpha-actinin-binding protein isoform d

    Status: VALIDATED

    Source sequence(s)
    AC124987
  17. NM_001411120.1NP_001398049.1  afadin- and alpha-actinin-binding protein isoform d

    Status: VALIDATED

    Source sequence(s)
    AC124987
  18. NM_001411121.1NP_001398050.1  afadin- and alpha-actinin-binding protein isoform e

    Status: VALIDATED

    Source sequence(s)
    AC124987
  19. NM_138744.4NP_620083.1  afadin- and alpha-actinin-binding protein isoform a

    See identical proteins and their annotated locations for NP_620083.1

    Status: VALIDATED

    Source sequence(s)
    AC124987, AK049080, AK173064, BE945817
    Consensus CDS
    CCDS38665.1
    UniProtKB/Swiss-Prot
    Q8K2F7, Q8VC66
    Related
    ENSMUSP00000101759.3, ENSMUST00000106153.9
    Conserved Domains (2) summary
    pfam11559
    Location:63214
    ADIP; Afadin- and alpha -actinin-Binding
    pfam17380
    Location:140301
    DUF5401; Family of unknown function (DUF5401)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    146110397..146145899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502405.5XP_006502468.1  afadin- and alpha-actinin-binding protein isoform X1

    UniProtKB/Swiss-Prot
    Q8VC66
    Conserved Domains (2) summary
    pfam11559
    Location:63214
    ADIP; Afadin- and alpha -actinin-Binding
    pfam17380
    Location:140301
    DUF5401; Family of unknown function (DUF5401)
  2. XM_006502406.4XP_006502469.1  afadin- and alpha-actinin-binding protein isoform X1

    UniProtKB/Swiss-Prot
    Q8VC66
    Conserved Domains (2) summary
    pfam11559
    Location:63214
    ADIP; Afadin- and alpha -actinin-Binding
    pfam17380
    Location:140301
    DUF5401; Family of unknown function (DUF5401)