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Anapc2 anaphase promoting complex subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 99152, updated on 8-Nov-2022

Summary

Official Symbol
Anapc2provided by MGI
Official Full Name
anaphase promoting complex subunit 2provided by MGI
Primary source
MGI:MGI:2139135
See related
Ensembl:ENSMUSG00000026965 AllianceGenome:MGI:2139135
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Apc2; Emi4; Imi4; mKIAA1406; 9230107K09Rik
Summary
This gene encodes a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle by ubiquitinating its specific substrates, such as mitotic cyclins and anaphase inhibitor, for subsequent degradation by the proteasome. [provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in ovary adult (RPKM 38.6), limb E14.5 (RPKM 34.9) and 28 other tissues See more
Orthologs
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Genomic context

See Anapc2 in Genome Data Viewer
Location:
2; 2 A3
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25162469..25175928)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25272466..25285916)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene taperin Neighboring gene SS nuclear autoantigen 1 Neighboring gene transmembrane protein 210 Neighboring gene leucine rich repeat containing 26 Neighboring gene glutamate receptor, ionotropic, NMDA1 (zeta 1)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of anaphase-promoting complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
anaphase-promoting complex subunit 2
Names
cyclosome subunit 2
expressed during mesenchymal induction 4
induced during mesenchymal induction 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175300.4NP_780509.2  anaphase-promoting complex subunit 2

    See identical proteins and their annotated locations for NP_780509.2

    Status: REVIEWED

    Source sequence(s)
    AA727217, AK033784, CJ072758, CJ164053, CR520037
    Consensus CDS
    CCDS15761.1
    UniProtKB/Swiss-Prot
    Q8BZQ7, Q8R2Q1
    Related
    ENSMUSP00000028341.5, ENSMUST00000028341.11
    Conserved Domains (2) summary
    smart01013
    Location:772832
    APC2; Anaphase promoting complex (APC) subunit 2
    smart00182
    Location:524657
    CULLIN; Cullin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    25162469..25175928
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004940791.1 RNA Sequence