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Stard7 StAR related lipid transfer domain containing 7 [ Mus musculus (house mouse) ]

Gene ID: 99138, updated on 8-Feb-2024

Summary

Official Symbol
Stard7provided by MGI
Official Full Name
StAR related lipid transfer domain containing 7provided by MGI
Primary source
MGI:MGI:2139090
See related
Ensembl:ENSMUSG00000027367 AllianceGenome:MGI:2139090
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable lipid binding activity. Acts upstream of or within several processes, including establishment of skin barrier; mucociliary clearance; and myeloid dendritic cell activation. Located in cytoplasm and extracellular region. Is expressed in central nervous system; liver; and retina. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 2. Orthologous to human STARD7 (StAR related lipid transfer domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 28.6), heart adult (RPKM 28.6) and 28 other tissues See more
Orthologs
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Genomic context

See Stard7 in Genome Data Viewer
Location:
2 F1; 2 61.88 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (127112123..127140855)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (127270202..127298935)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E642 Neighboring gene cytosolic iron-sulfur protein assembly 1 Neighboring gene transmembrane protein 127 Neighboring gene STARR-positive B cell enhancer mm9_chr2:127095727-127096028 Neighboring gene STARR-seq mESC enhancer starr_05622 Neighboring gene STARR-positive B cell enhancer ABC_E4496 Neighboring gene STARR-positive B cell enhancer ABC_E10138 Neighboring gene predicted gene, 54150 Neighboring gene predicted gene, 46762 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:127154244-127154469 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:127160153-127160262 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:127160377-127160560 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:127160818-127161005

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
stAR-related lipid transfer protein 7, mitochondrial
Names
START domain containing 7
START domain-containing protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362684.2NP_001349613.1  stAR-related lipid transfer protein 7, mitochondrial isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL845368
    Conserved Domains (1) summary
    cl14643
    Location:139186
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
  2. NM_139308.3NP_647469.2  stAR-related lipid transfer protein 7, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_647469.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL845368
    Consensus CDS
    CCDS16698.2
    UniProtKB/Swiss-Prot
    A2ARG0, Q8R1R3
    UniProtKB/TrEMBL
    F7BBA2, Q8BUP0
    Related
    ENSMUSP00000106004.3, ENSMUST00000110375.9
    Conserved Domains (1) summary
    cd08911
    Location:139328
    START_STARD7-like; Lipid-binding START domain of mammalian STARD7 and related proteins

RNA

  1. NR_156114.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate coding exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL845368
  2. NR_188880.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL845368

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    127112123..127140855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003953755.2 RNA Sequence