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SUPT7L SPT7 like, STAGA complex subunit gamma [ Homo sapiens (human) ]

Gene ID: 9913, updated on 26-Nov-2021

Summary

Official Symbol
SUPT7Lprovided by HGNC
Official Full Name
SPT7 like, STAGA complex subunit gammaprovided by HGNC
Primary source
HGNC:HGNC:30632
See related
Ensembl:ENSG00000119760 MIM:612762
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPT7L; STAF65; SUPT7H; STAF65G; STAF65(gamma)
Summary
SUPT7L is a protein subunit of the human STAGA complex (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301) acetyltransferase complex), which is a chromatin-modifying multiprotein complex (Martinez et al., 2001 [PubMed 11564863]).[supplied by OMIM, Apr 2009]
Expression
Ubiquitous expression in brain (RPKM 10.8), spleen (RPKM 8.8) and 25 other tissues See more
Orthologs
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Genomic context

See SUPT7L in Genome Data Viewer
Location:
2p23.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (27642568..27663824, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27873676..27886481, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 512 Neighboring gene coiled-coil domain containing 121 Neighboring gene GPN-loop GTPase 1 Neighboring gene solute carrier family 4 member 1 adaptor protein Neighboring gene long intergenic non-protein coding RNA 1460

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0764, MGC90306

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of SAGA complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
STAGA complex 65 subunit gamma
Names
SPT7 like, STAGA complex gamma subunit
SPTF-associated factor 65 gamma
STAF65gamma
STAGA complex 65 gamma subunit
adenocarcinoma antigen ART1
suppressor of Ty 7-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282729.2NP_001269658.1  STAGA complex 65 subunit gamma isoform a

    See identical proteins and their annotated locations for NP_001269658.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode isoform a.
    Source sequence(s)
    AB018307, AC074091, BC074000, CF528942, DA398215
    Consensus CDS
    CCDS42667.1
    UniProtKB/Swiss-Prot
    O94864
    Conserved Domains (1) summary
    smart00576
    Location:151226
    BTP; Bromodomain transcription factors and PHD domain containing proteins
  2. NM_001282730.2NP_001269659.1  STAGA complex 65 subunit gamma isoform b

    See identical proteins and their annotated locations for NP_001269659.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and uses an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a. Both variants 3 and 4 encode isoform b.
    Source sequence(s)
    AB018307, AC074091, BC045638, CF528942, DA398215
    Consensus CDS
    CCDS62885.1
    UniProtKB/Swiss-Prot
    O94864
    Related
    ENSP00000384469.1, ENST00000405491.5
    Conserved Domains (1) summary
    smart00576
    Location:149224
    BTP; Bromodomain transcription factors and PHD domain containing proteins
  3. NM_001282731.2NP_001269660.1  STAGA complex 65 subunit gamma isoform b

    See identical proteins and their annotated locations for NP_001269660.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR and uses an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a. Both variants 3 and 4 encode isoform b.
    Source sequence(s)
    AB018307, AC074091, AF197954, BI755200, CF528942, DA001757
    Consensus CDS
    CCDS62885.1
    UniProtKB/Swiss-Prot
    O94864
    Conserved Domains (1) summary
    smart00576
    Location:149224
    BTP; Bromodomain transcription factors and PHD domain containing proteins
  4. NM_001282732.2NP_001269661.1  STAGA complex 65 subunit gamma isoform c

    See identical proteins and their annotated locations for NP_001269661.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
    Source sequence(s)
    AB018307, AC074091, AK304889, CF528942
    Consensus CDS
    CCDS62886.1
    UniProtKB/Swiss-Prot
    O94864
    Related
    ENSP00000385218.2, ENST00000404798.6
    Conserved Domains (1) summary
    smart00576
    Location:1691
    BTP; Bromodomain transcription factors and PHD domain containing proteins
  5. NM_014860.3NP_055675.1  STAGA complex 65 subunit gamma isoform a

    See identical proteins and their annotated locations for NP_055675.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Both variants 1 and 2 encode isoform a.
    Source sequence(s)
    AB018307, AC074091, AF197954, CF528942, DA398215
    Consensus CDS
    CCDS42667.1
    UniProtKB/Swiss-Prot
    O94864
    Related
    ENSP00000336750.5, ENST00000337768.10
    Conserved Domains (1) summary
    smart00576
    Location:151226
    BTP; Bromodomain transcription factors and PHD domain containing proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    27642568..27663824 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264672.4XP_005264729.1  STAGA complex 65 subunit gamma isoform X1

    See identical proteins and their annotated locations for XP_005264729.1

    UniProtKB/Swiss-Prot
    O94864
    Conserved Domains (1) summary
    smart00576
    Location:149224
    BTP; Bromodomain transcription factors and PHD domain containing proteins

RNA

  1. XR_939750.3 RNA Sequence

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