U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lpcat4 lysophosphatidylcholine acyltransferase 4 [ Mus musculus (house mouse) ]

Gene ID: 99010, updated on 27-Nov-2024

Summary

Official Symbol
Lpcat4provided by MGI
Official Full Name
lysophosphatidylcholine acyltransferase 4provided by MGI
Primary source
MGI:MGI:2138993
See related
Ensembl:ENSMUSG00000027134 AllianceGenome:MGI:2138993
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aytl3; Agpat7; LPEAT2
Summary
Enables 1-acylglycerophosphocholine O-acyltransferase activity. Involved in phosphatidylcholine acyl-chain remodeling. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human LPCAT4 (lysophosphatidylcholine acyltransferase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in stomach adult (RPKM 59.3), cortex adult (RPKM 45.0) and 22 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Lpcat4 in Genome Data Viewer
Location:
2 E3; 2 56.96 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (112070186..112077456)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (112239841..112247111)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene olfactory receptor 1319, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_05384 Neighboring gene STARR-positive B cell enhancer mm9_chr2:112037072-112037373 Neighboring gene STARR-seq mESC enhancer starr_05385 Neighboring gene PRELI domain containing 1 pseudogene Neighboring gene predicted gene, 52523 Neighboring gene NUT midline carcinoma, family member 1 Neighboring gene STARR-positive B cell enhancer ABC_E4485 Neighboring gene NOP10 ribonucleoprotein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
lysophospholipid acyltransferase LPCAT4
Names
-acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta)
1-AGP acyltransferase 7
1-AGPAT 7
1-acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta)
1-acylglycerophosphocholine O-acyltransferase
1-acylglycerophosphoserine O-acyltransferase
1-alkenylglycerophosphoethanolamine O-acyltransferase
1-alkylglycerophosphocholine O-acetyltransferase
acyltransferase-like 3
lysophosphatidylethanolamine acyltransferase 2
plasmalogen synthase
NP_997089.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207206.2NP_997089.1  lysophospholipid acyltransferase LPCAT4

    See identical proteins and their annotated locations for NP_997089.1

    Status: VALIDATED

    Source sequence(s)
    AL713853, BC068131
    Consensus CDS
    CCDS16548.1
    UniProtKB/Swiss-Prot
    Q66JP7, Q6NVG1
    Related
    ENSMUSP00000028554.4, ENSMUST00000028554.4
    Conserved Domains (2) summary
    cd07991
    Location:109306
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
    COG0204
    Location:109295
    PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    112070186..112077456
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)