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CDC6 cell division cycle 6 [ Homo sapiens (human) ]

Gene ID: 990, updated on 1-Jun-2020

Summary

Official Symbol
CDC6provided by HGNC
Official Full Name
cell division cycle 6provided by HGNC
Primary source
HGNC:HGNC:1744
See related
Ensembl:ENSG00000094804 MIM:602627
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDC18L; HsCDC6; MGORS5; HsCDC18
Summary
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]
Expression
Broad expression in bone marrow (RPKM 5.8), lymph node (RPKM 4.9) and 20 other tissues See more
Orthologs

Genomic context

See CDC6 in Genome Data Viewer
Location:
17q21.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (40287878..40304657)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38444146..38459413)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Rap guanine nucleotide exchange factor like 1 Neighboring gene microRNA 6867 Neighboring gene WAS/WASL interacting protein family member 2 Neighboring gene RNY4 pseudogene 8 Neighboring gene uncharacterized LOC105371934 Neighboring gene retinoic acid receptor alpha Neighboring gene RARA antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
nucleotide binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA replication TAS
Traceable Author Statement
more info
 
DNA replication checkpoint TAS
Traceable Author Statement
more info
PubMed 
DNA replication initiation IEA
Inferred from Electronic Annotation
more info
 
G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to angiotensin IEA
Inferred from Electronic Annotation
more info
 
cellular response to vasopressin IEA
Inferred from Electronic Annotation
more info
 
mitotic DNA replication checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA replication TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of chromosome segregation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of cyclin-dependent protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
regulation of mitotic metaphase/anaphase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription involved in G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
traversing start control point of mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
NOT nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
spindle midzone IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cell division control protein 6 homolog
Names
CDC6 cell division cycle 6 homolog
CDC6-related protein
cdc18-related protein
cell division cycle 6 homolog
p62(cdc6)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028240.2 RefSeqGene

    Range
    5001..21779
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001254.4NP_001245.1  cell division control protein 6 homolog

    See identical proteins and their annotated locations for NP_001245.1

    Status: REVIEWED

    Source sequence(s)
    AC080112, AK313620, BC025232
    Consensus CDS
    CCDS11365.1
    UniProtKB/Swiss-Prot
    Q99741
    UniProtKB/TrEMBL
    A0A024R1S2
    Related
    ENSP00000209728.4, ENST00000209728.9
    Conserved Domains (3) summary
    smart01074
    Location:465545
    Cdc6_C; CDC6, C terminal
    COG1474
    Location:168547
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam13191
    Location:171314
    AAA_16; AAA ATPase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    40287878..40304657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525541.2XP_011523843.1  cell division control protein 6 homolog isoform X1

    See identical proteins and their annotated locations for XP_011523843.1

    Conserved Domains (3) summary
    smart01074
    Location:505585
    Cdc6_C; CDC6, C terminal
    COG1474
    Location:168587
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam13191
    Location:171314
    AAA_16; AAA ATPase domain
  2. XM_011525542.1XP_011523844.1  cell division control protein 6 homolog isoform X1

    See identical proteins and their annotated locations for XP_011523844.1

    Conserved Domains (3) summary
    smart01074
    Location:505585
    Cdc6_C; CDC6, C terminal
    COG1474
    Location:168587
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam13191
    Location:171314
    AAA_16; AAA ATPase domain
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