Znfx1 zinc finger, NFX1-type containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Znfx1provided by MGI
Official Full Name: zinc finger, NFX1-type containing 1provided by MGI
Primary source: MGI:MGI:2138982
See related: Ensembl:ENSMUSG00000039501 AllianceGenome:MGI:2138982
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Astx3
Summary: Predicted to enable RNA binding activity. Predicted to be involved in heterochromatin assembly by small RNA. Predicted to be located in nucleus. Predicted to be part of nuclear RNA-directed RNA polymerase complex. Orthologous to human ZNFX1 (zinc finger NFX1-type containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in kidney adult (RPKM 12.8), genital fat pad adult (RPKM 12.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2; 2 H3

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (166877710..166904935, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (167035790..167063015, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitochondria-localized ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS.
Title: Mitochondria-localised ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Znfx1 gene: The Znfx1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, and frog.
Orthologs from Annotation Pipeline: 456 organisms have orthologs with human gene Znfx1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA-mediated heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in activation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of viral genome replication	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of nuclear RNA-directed RNA polymerase complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NFX1-type zinc finger-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033196.2 → NP_001028368.2 NFX1-type zinc finger-containing protein 1 isoform a

See identical proteins and their annotated locations for NP_001028368.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AK149249, AL591711, BC059933

Consensus CDS

CCDS38337.1

UniProtKB/Swiss-Prot

Q3UEZ0, Q8R151

Related

ENSMUSP00000049404.8, ENSMUST00000048988.14

Conserved Domains (6) summary

cd06008
Location:1453 → 1497

NF-X1-zinc-finger; Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger ...

PRK03918
Location:1597 → 1808

PRK03918; DNA double-strand break repair ATPase Rad50

cd18808
Location:1068 → 1244

SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases

cd17936
Location:971 → 1066

EEXXEc_NFX1; EEXXE-box helicase domain of NFX1

pfam01500
Location:1425 → 1563

Keratin_B2; Keratin, high sulfur B2 protein

pfam13086
Location:897 → 1031

AAA_11; AAA domain
NM_001291162.1 → NP_001278091.1 NFX1-type zinc finger-containing protein 1 isoform b precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks several 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.

Source sequence(s)

AL591711, BC059933

Consensus CDS

CCDS71198.1

UniProtKB/TrEMBL

A2A5R6

Related

ENSMUSP00000072867.6, ENSMUST00000067584.7

Conserved Domains (4) summary

cd06008
Location:589 → 633

NF-X1-zinc-finger; Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger ...

COG1112
Location:63 → 383

DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]

pfam15042
Location:626 → 690

LELP1; Late cornified envelope-like proline-rich protein 1

cl22977
Location:180 → 363

UvrD_C_2; UvrD-like helicase C-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

166877710..166904935 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006500456.4 → XP_006500519.1 NFX1-type zinc finger-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_006500519.1

UniProtKB/Swiss-Prot

Q3UEZ0, Q8R151

Conserved Domains (6) summary

cd06008
Location:1453 → 1497

NF-X1-zinc-finger; Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger ...

PRK03918
Location:1597 → 1808

PRK03918; DNA double-strand break repair ATPase Rad50

cd18808
Location:1068 → 1244

SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases

cd17936
Location:971 → 1066

EEXXEc_NFX1; EEXXE-box helicase domain of NFX1

pfam01500
Location:1425 → 1563

Keratin_B2; Keratin, high sulfur B2 protein

pfam13086
Location:897 → 1031

AAA_11; AAA domain
XM_036162742.1 → XP_036018635.1 NFX1-type zinc finger-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

Q3UEZ0

Conserved Domains (6) summary

cd06008
Location:1453 → 1497

NF-X1-zinc-finger; Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger ...

PRK03918
Location:1597 → 1808

PRK03918; DNA double-strand break repair ATPase Rad50

cd18808
Location:1068 → 1244

SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases

cd17936
Location:971 → 1066

EEXXEc_NFX1; EEXXE-box helicase domain of NFX1

pfam01500
Location:1425 → 1563

Keratin_B2; Keratin, high sulfur B2 protein

pfam13086
Location:897 → 1031

AAA_11; AAA domain