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Myl9 myosin, light polypeptide 9, regulatory [ Mus musculus (house mouse) ]

Gene ID: 98932, updated on 21-Feb-2023

Summary

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Official Symbol
Myl9provided by MGI
Official Full Name
myosin, light polypeptide 9, regulatoryprovided by MGI
Primary source
MGI:MGI:2138915
See related
Ensembl:ENSMUSG00000067818 AllianceGenome:MGI:2138915
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MLC20; RLC-C; Mylc2c
Summary
Enables myosin heavy chain binding activity. Located in Z disc and stress fiber. Part of myosin II complex. Is expressed in several structures, including cardiovascular system; future spinal cord; genitourinary system; gut; and lung. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy. Orthologous to human MYL9 (myosin light chain 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 1647.7), colon adult (RPKM 313.1) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Myl9 in Genome Data Viewer
Location:
2; 2 H1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (156617324..156623577)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (156775408..156781657)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene DLG associated protein 4 Neighboring gene predicted gene, 52566 Neighboring gene RIKEN cDNA 4930405A21 gene Neighboring gene ribosomal protein L9 pseudogene Neighboring gene VISTA enhancer mm1377

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MYL9 deficiency is neonatal lethal in mice due to abnormalities in the lung and the muscularis propria of the bladder and intestine. Huang CH, et al. PLoS One, 2022. PMID 35802750, Free PMC Article
  2. Integrin β1 coordinates survival and morphogenesis of the embryonic lineage upon implantation and pluripotency transition. Molè MA, et al. Cell Rep, 2021 Mar 9. PMID 33691117, Free PMC Article
  3. Connexin 40 regulates lung endothelial permeability in acute lung injury via the ROCK1-MYPT1- MLC20 pathway. Yin J, et al. Am J Physiol Lung Cell Mol Physiol, 2019 Jan 1. PMID 30234377
  4. Deletion of Mylk1 in oocytes causes delayed morula-to-blastocyst transition and reduced fertility without affecting folliculogenesis and oocyte maturation in mice. Liang QX, et al. Biol Reprod, 2015 Apr. PMID 25761595
  5. Molecular mechanism of telokin-mediated disinhibition of myosin light chain phosphatase and cAMP/cGMP-induced relaxation of gastrointestinal smooth muscle. Khromov AS, et al. J Biol Chem, 2012 Jun 15. PMID 22544752, Free PMC Article

See all (74) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MYL9 deficiency is neonatal lethal in mice due to abnormalities in the lung and the muscularis propria of the bladder and intestine.
    Title: MYL9 deficiency is neonatal lethal in mice due to abnormalities in the lung and the muscularis propria of the bladder and intestine.
  2. findings reveal a role of Cx40 in regulation of ROCK1 and MLC20 that contributes critically to lung vascular barrier failure in acute lung injury.
    Title: Connexin 40 regulates lung endothelial permeability in acute lung injury via the ROCK1-MYPT1- MLC20 pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin heavy chain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in myofibril assembly IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in myofibril IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of myosin II complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in stress fiber IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
myosin regulatory light polypeptide 9
Names
myosin light chain, regulatory C
myosin regulatory light chain 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172118.1 → NP_742116.1  myosin regulatory light polypeptide 9

    See identical proteins and their annotated locations for NP_742116.1

    Status: PROVISIONAL

    Source sequence(s)
    AK020258
    Consensus CDS
    CCDS50779.1
    UniProtKB/Swiss-Prot
    Q80X77, Q9CQ19
    UniProtKB/TrEMBL
    A0A6P5P3L0, A0A8C6GI73
    Related
    ENSMUSP00000085913.7, ENSMUST00000088552.7
    Conserved Domains (1) summary
    COG5126
    Location:19 → 169
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    156617324..156623577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500453.5 → XP_006500516.1  myosin regulatory light polypeptide 9 isoform X1

    See identical proteins and their annotated locations for XP_006500516.1

    UniProtKB/Swiss-Prot
    Q80X77, Q9CQ19
    UniProtKB/TrEMBL
    A0A6P5P3L0, A0A8C6GI73
    Conserved Domains (1) summary
    COG5126
    Location:19 → 169
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQ19.3 GenPept UniProtKB/Swiss-Prot:Q9CQ19

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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