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POM121 POM121 transmembrane nucleoporin [ Homo sapiens (human) ]

Gene ID: 9883, updated on 21-Aug-2021

Summary

Official Symbol
POM121provided by HGNC
Official Full Name
POM121 transmembrane nucleoporinprovided by HGNC
Primary source
HGNC:HGNC:19702
See related
Ensembl:ENSG00000196313 MIM:615753
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P145; POM121A
Summary
This gene encodes a transmembrane protein that localizes to the inner nuclear membrane and forms a core component of the nuclear pore complex, which mediates transport to and from the nucleus. The encoded protein may anchor this complex to the nuclear envelope. There are multiple related genes and pseudogenes for this gene on chromosomes 5, 7, 15, and 22. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]
Annotation information
Note: POM121 (Gene ID: 9883) and POMZP3 (Gene ID: 22832) share the POM121 symbol/alias in common. POM121 is sometimes used as an alternative name for POM121 and ZP3 fusion, which can be confused with the official symbol for POM121 transmembrane nucleoporin (POM121). [05 Jul 2018]
Expression
Ubiquitous expression in bone marrow (RPKM 16.6), spleen (RPKM 15.4) and 25 other tissues See more
Orthologs
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Genomic context

See POM121 in Genome Data Viewer
Location:
7q11.23
Exon count:
22
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (72879357..72951459)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (72349928..72421998)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 625, pseudogene Neighboring gene speedy/RINGO cell cycle regulator family member E7, pseudogene Neighboring gene NSUN5 pseudogene 2 Neighboring gene tripartite motif containing 74 Neighboring gene FKBP prolyl isomerase 6 pseudogene Neighboring gene stromal antigen 3-like 3 (pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3792, FLJ41820, KIAA0618, DKFZp586G1822, DKFZp586P2220

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear envelope TAS
Traceable Author Statement
more info
 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
nuclear envelope pore membrane protein POM 121
Names
POM121 membrane glycoprotein
nuclear envelope pore membrane protein POM 121A
nuclear pore membrane protein 121 kDa
nucleoporin Nup121

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001257190.3NP_001244119.1  nuclear envelope pore membrane protein POM 121 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AB014518, AC211476, BC001518, BG831530, BI544820, DC361358
    Consensus CDS
    CCDS59059.1
    UniProtKB/Swiss-Prot
    Q96HA1
    Related
    ENSP00000378687.1, ENST00000395270.5
    Conserved Domains (1) summary
    pfam15229
    Location:56287
    POM121; POM121 family
  2. NM_001367610.1NP_001354539.1  nuclear envelope pore membrane protein POM 121 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC211469, AC211476
    Conserved Domains (2) summary
    PHA03247
    Location:303666
    PHA03247; large tegument protein UL36; Provisional
    pfam15229
    Location:56287
    POM121; POM121 family
  3. NM_001387685.1NP_001374614.1  nuclear envelope pore membrane protein POM 121 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC211469, AC211476
    Conserved Domains (2) summary
    PHA03247
    Location:362725
    PHA03247; large tegument protein UL36; Provisional
    pfam15229
    Location:56287
    POM121; POM121 family
  4. NM_001387686.1NP_001374615.1  nuclear envelope pore membrane protein POM 121 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC211469, AC211476
    Related
    ENSP00000486504.1, ENST00000627934.2
    Conserved Domains (2) summary
    PHA03247
    Location:362725
    PHA03247; large tegument protein UL36; Provisional
    pfam15229
    Location:56287
    POM121; POM121 family
  5. NM_001387687.1NP_001374616.1  nuclear envelope pore membrane protein POM 121 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC211469, AC211476
    Conserved Domains (2) summary
    PHA03247
    Location:362725
    PHA03247; large tegument protein UL36; Provisional
    pfam15229
    Location:56287
    POM121; POM121 family
  6. NM_001387688.1NP_001374617.1  nuclear envelope pore membrane protein POM 121 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC211469, AC211476
    Conserved Domains (2) summary
    PHA03247
    Location:362725
    PHA03247; large tegument protein UL36; Provisional
    pfam15229
    Location:56287
    POM121; POM121 family
  7. NM_001387689.1NP_001374618.1  nuclear envelope pore membrane protein POM 121 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC211469, AC211476
    Conserved Domains (2) summary
    PHA03247
    Location:362725
    PHA03247; large tegument protein UL36; Provisional
    pfam15229
    Location:56287
    POM121; POM121 family
  8. NM_001387691.1NP_001374620.1  nuclear envelope pore membrane protein POM 121 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC211476
    Related
    ENSP00000405562.2, ENST00000434423.5
    Conserved Domains (2) summary
    PHA03247
    Location:627990
    PHA03247; large tegument protein UL36; Provisional
    pfam15229
    Location:321552
    POM121; POM121 family
  9. NM_001387692.1NP_001374621.1  nuclear envelope pore membrane protein POM 121 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC211476
    Conserved Domains (3) summary
    PRK12688
    Location:9711176
    PRK12688; flagellin; Reviewed
    PHA03247
    Location:568931
    PHA03247; large tegument protein UL36; Provisional
    pfam15229
    Location:321552
    POM121; POM121 family
  10. NM_001387693.1NP_001374622.1  nuclear envelope pore membrane protein POM 121 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC211476
    Conserved Domains (2) summary
    PHA03247
    Location:531894
    PHA03247; large tegument protein UL36; Provisional
    pfam15229
    Location:321456
    POM121; POM121 family
  11. NM_001387694.1NP_001374623.1  nuclear envelope pore membrane protein POM 121 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC211469, AC211476
    Conserved Domains (2) summary
    PHA03247
    Location:368731
    PHA03247; large tegument protein UL36; Provisional
    pfam15229
    Location:56287
    POM121; POM121 family
  12. NM_001387695.1NP_001374624.1  nuclear envelope pore membrane protein POM 121 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC211469, AC211476
    Conserved Domains (2) summary
    PHA03247
    Location:362725
    PHA03247; large tegument protein UL36; Provisional
    pfam15229
    Location:56287
    POM121; POM121 family
  13. NM_001387696.1NP_001374625.1  nuclear envelope pore membrane protein POM 121 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC211469, AC211476
    Conserved Domains (2) summary
    PHA03247
    Location:362725
    PHA03247; large tegument protein UL36; Provisional
    pfam15229
    Location:56287
    POM121; POM121 family
  14. NM_001387697.1NP_001374626.1  nuclear envelope pore membrane protein POM 121 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC211469, AC211476
    Conserved Domains (2) summary
    PHA03247
    Location:362725
    PHA03247; large tegument protein UL36; Provisional
    pfam15229
    Location:56287
    POM121; POM121 family
  15. NM_001387698.1NP_001374627.1  nuclear envelope pore membrane protein POM 121 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC211469, AC211476
    Conserved Domains (2) summary
    PHA03247
    Location:362725
    PHA03247; large tegument protein UL36; Provisional
    pfam15229
    Location:56287
    POM121; POM121 family
  16. NM_001387699.1NP_001374628.1  nuclear envelope pore membrane protein POM 121 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC211469, AC211476
    Conserved Domains (2) summary
    PHA03247
    Location:362725
    PHA03247; large tegument protein UL36; Provisional
    pfam15229
    Location:56287
    POM121; POM121 family
  17. NM_001387700.1NP_001374629.1  nuclear envelope pore membrane protein POM 121 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC211469, AC211476
    Conserved Domains (2) summary
    PHA03247
    Location:362725
    PHA03247; large tegument protein UL36; Provisional
    pfam15229
    Location:56287
    POM121; POM121 family
  18. NM_001387701.1NP_001374630.1  nuclear envelope pore membrane protein POM 121 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC211469, AC211476
    Conserved Domains (2) summary
    PHA03247
    Location:303666
    PHA03247; large tegument protein UL36; Provisional
    pfam15229
    Location:56287
    POM121; POM121 family
  19. NM_001387702.1NP_001374631.1  nuclear envelope pore membrane protein POM 121 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC211469, AC211476
    Conserved Domains (2) summary
    PHA03247
    Location:303666
    PHA03247; large tegument protein UL36; Provisional
    pfam15229
    Location:56287
    POM121; POM121 family
  20. NM_001387703.1NP_001374632.1  nuclear envelope pore membrane protein POM 121 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC211469, AC211476
    Conserved Domains (2) summary
    PHA03247
    Location:303666
    PHA03247; large tegument protein UL36; Provisional
    pfam15229
    Location:56287
    POM121; POM121 family
  21. NM_001387704.1NP_001374633.1  nuclear envelope pore membrane protein POM 121 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC211469, AC211476
    Conserved Domains (2) summary
    PHA03247
    Location:303666
    PHA03247; large tegument protein UL36; Provisional
    pfam15229
    Location:56287
    POM121; POM121 family
  22. NM_001387705.1NP_001374634.1  nuclear envelope pore membrane protein POM 121 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC211469, AC211476
    Conserved Domains (2) summary
    PHA03247
    Location:266629
    PHA03247; large tegument protein UL36; Provisional
    pfam15229
    Location:56191
    POM121; POM121 family
  23. NM_172020.5NP_742017.1  nuclear envelope pore membrane protein POM 121 isoform 2

    See identical proteins and their annotated locations for NP_742017.1

    Status: REVIEWED

    Source sequence(s)
    AC211469, AC211476
    Consensus CDS
    CCDS5542.1
    UniProtKB/Swiss-Prot
    Q96HA1
    Conserved Domains (2) summary
    PHA03247
    Location:362725
    PHA03247; large tegument protein UL36; Provisional
    pfam15229
    Location:56287
    POM121; POM121 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    72879357..72951459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_014833.1: Suppressed sequence

    Description
    NM_014833.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
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