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TOX4 TOX high mobility group box family member 4 [ Homo sapiens (human) ]

Gene ID: 9878, updated on 11-Jun-2025
Official Symbol
TOX4provided by HGNC
Official Full Name
TOX high mobility group box family member 4provided by HGNC
Primary source
HGNC:HGNC:20161
See related
Ensembl:ENSG00000092203 MIM:614032; AllianceGenome:HGNC:20161
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LCP1; MIG7; C14orf92; KIAA0737
Summary
Predicted to enable chromatin DNA binding activity. Involved in RNA polymerase II promoter clearance and positive regulation of transcription elongation by RNA polymerase II. Located in chromatin and chromosome, telomeric region. Part of PTW/PP1 phosphatase complex. [provided by Alliance of Genome Resources, Jun 2025]
Orthologs
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See TOX4 in Genome Data Viewer
Location:
14q11.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (21477195..21499170)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (15674564..15696534)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21945354..21967314)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene chromodomain helicase DNA binding protein 8 Neighboring gene RNA, 7SL, cytoplasmic 650, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:21905321-21905864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8103 Neighboring gene Sharpr-MPRA regulatory region 12162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:21910077-21910995 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:21920455-21920954 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:21924579-21925130 Neighboring gene uncharacterized LOC124903283 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:21925131-21925682 Neighboring gene RAB2B, member RAS oncogene family Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8110 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8111 Neighboring gene methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:21987519-21988018 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:21991711-21991897 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:21992413-21993240 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:21994071-21994898 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:21994899-21995726 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:22002164-22003029 Neighboring gene spalt like transcription factor 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:22010043-22010544 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:22010545-22011044 Neighboring gene MPRA-validated peak2117 silencer Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:22025683-22026226 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:22026227-22026770 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:22026789-22026975 Neighboring gene RBBP4 pseudogene 5

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated TOX high mobility group box family member 4 (TOX4) is incorporated into HIV-1 Gag virus-like particles PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of PTW/PP1 phosphatase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in chromatin IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
TOX high mobility group box family member 4
Names
epidermal Langerhans cell protein LCP1
migration-inducing protein 7

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303523.2NP_001290452.1  TOX high mobility group box family member 4 isoform 2

    See identical proteins and their annotated locations for NP_001290452.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK298555, AL161747, BC020292, DA334895, N63399
    UniProtKB/TrEMBL
    B4DJ39
    Conserved Domains (2) summary
    COG5648
    Location:117283
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd00084
    Location:200265
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
  2. NM_014828.4NP_055643.1  TOX high mobility group box family member 4 isoform 1

    See identical proteins and their annotated locations for NP_055643.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL161747, BC020292, DA334895, N63399
    Consensus CDS
    CCDS32043.1
    UniProtKB/Swiss-Prot
    B4DPY8, B4DSM0, E7EV69, O94842
    UniProtKB/TrEMBL
    B4DJ39
    Related
    ENSP00000393080.3, ENST00000448790.7
    Conserved Domains (2) summary
    COG5648
    Location:140306
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd00084
    Location:223288
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    21477195..21499170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    15674564..15696534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)