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Rab3gap2 RAB3 GTPase activating protein subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 98732, updated on 12-Aug-2019

Summary

Official Symbol
Rab3gap2provided by MGI
Official Full Name
RAB3 GTPase activating protein subunit 2provided by MGI
Primary source
MGI:MGI:1916043
See related
Ensembl:ENSMUSG00000039318
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI851069; AW743433; mKIAA0839; 5830469C09; RAB3-GAP150; 1110059F07Rik; 2010002H18Rik
Expression
Ubiquitous expression in frontal lobe adult (RPKM 9.3), cortex adult (RPKM 8.7) and 28 other tissues See more
Orthologs

Genomic context

See Rab3gap2 in Genome Data Viewer
Location:
1; 1 H5
Exon count:
35
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (185204088..185286756)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (187028047..187110625)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 34732 Neighboring gene predicted gene, 37662 Neighboring gene predicted gene, 34797 Neighboring gene small nucleolar RNA, H/ACA box 36B Neighboring gene predicted gene, 34882 Neighboring gene microRNA 664 Neighboring gene isoleucine-tRNA synthetase 2, mitochondrial Neighboring gene microRNA 194-1 Neighboring gene microRNA 215

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
Rab GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Rab guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to Rab guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enzyme regulator activity ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
establishment of protein localization to endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
positive regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endoplasmic reticulum tubular network organization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein lipidation ISO
Inferred from Sequence Orthology
more info
 
regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
rab3 GTPase-activating protein non-catalytic subunit
Names
Rab3 GTPase-activating protein 150 kDa subunit
Rab3-GAP regulatory subunit
rab3-GAP p150

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163754.1NP_001157226.1  rab3 GTPase-activating protein non-catalytic subunit

    Status: VALIDATED

    Source sequence(s)
    AC131084, AC158963, AK031191, AK037092, AK149265, BB870581, BQ176759, CN459207
    Consensus CDS
    CCDS48478.1
    UniProtKB/Swiss-Prot
    Q8BMG7
    UniProtKB/TrEMBL
    E9QKE4, Q3UEY3, Q8BYZ6
    Related
    ENSMUSP00000066325.6, ENSMUST00000069652.7
    Conserved Domains (2) summary
    pfam14655
    Location:73497
    RAB3GAP2_N; Rab3 GTPase-activating protein regulatory subunit N-terminus
    pfam14656
    Location:7791365
    RAB3GAP2_C; Rab3 GTPase-activating protein regulatory subunit C-terminus

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p6 C57BL/6J

    Range
    185204088..185286756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497216.4XP_006497279.1  rab3 GTPase-activating protein non-catalytic subunit isoform X1

    UniProtKB/TrEMBL
    A0A0A6YWM5
    Related
    ENSMUSP00000141608.1, ENSMUST00000194740.5
    Conserved Domains (2) summary
    pfam14655
    Location:73497
    RAB3GAP2_N; Rab3 GTPase-activating protein regulatory subunit N-terminus
    pfam14656
    Location:7791345
    RAB3GAP2_C; Rab3 GTPase-activating protein regulatory subunit C-terminus

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172649.1: Suppressed sequence

    Description
    NM_172649.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: RAB3GAP2 (GeneID:25782).
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