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prfA listeriolysin positive regulatory protein [ Listeria monocytogenes EGD-e ]

Gene ID: 987031, updated on 6-Jun-2024
Gene symbol
prfA
Gene description
listeriolysin positive regulatory protein
Locus tag
lmo0200
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Listeria monocytogenes EGD-e (strain: EGD-e)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria
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Sequence:
NC_003210.1 (203640..204353, complement)

NC_003210.1Genomic Context describing neighboring genes Neighboring gene bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase Neighboring gene ribose-phosphate pyrophosphokinase Neighboring gene miscRNA Neighboring gene phosphatidylinositol-specific phospholipase c Neighboring gene listeriolysin O precursor

Genomic Sequence:
NC_003210.1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A naturally occurring prfA truncation in a Listeria monocytogenes field strain contributes to reduced replication and cell-to-cell spread. Rupp S, et al. Vet Microbiol, 2015 Aug 31. PMID 25813546
  2. A naturally occurring mutation K220T in the pleiotropic activator PrfA of Listeria monocytogenes results in a loss of virulence due to decreasing DNA-binding affinity. Velge P, et al. Microbiology (Reading), 2007 Apr. PMID 17379709
  3. A PrfA-regulated bile exclusion system (BilE) is a novel virulence factor in Listeria monocytogenes. Sleator RD, et al. Mol Microbiol, 2005 Feb. PMID 15686563
  4. Characterization of the roles of activated charcoal and Chelex in the induction of PrfA regulon expression in complex medium. Gaballa A, et al. PLoS One, 2021. PMID 33914817, Free PMC Article
  5. Spontaneous Loss of Virulence in Natural Populations of Listeria monocytogenes. Maury MM, et al. Infect Immun, 2017 Nov. PMID 28827366, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Characterization of the roles of activated charcoal and Chelex in the induction of PrfA regulon expression in complex medium.
    Title: Characterization of the roles of activated charcoal and Chelex in the induction of PrfA regulon expression in complex medium.
  2. Spontaneous loss of virulence in natural populations of Listeria monocytogenes due to mutations in hlyA and PrfA has been demonstrated.
    Title: Spontaneous Loss of Virulence in Natural Populations of Listeria monocytogenes.
  3. PepP peptidase plays a role in posttranslational activation of the major virulence regulator, PrfA. PepP mediates recruitment of PrfA to the cytoplasmic membrane.
    Title: Metabolic Genetic Screens Reveal Multidimensional Regulation of Virulence Gene Expression in Listeria monocytogenes and an Aminopeptidase That Is Critical for PrfA Protein Activation.
  4. The truncated C-terminus of prfA considerably contributes to the strongly attenuated phenotype observed in vitro.
    Title: A naturally occurring prfA truncation in a Listeria monocytogenes field strain contributes to reduced replication and cell-to-cell spread.
  5. PrfA K220T amino acid substituted mutant gene in an EGDDeltaprfA strain did not restore the haemolytic and phosphatidylcholine phospholipase C activities, in contrast to the wild-type prfA gene.
    Title: A naturally occurring mutation K220T in the pleiotropic activator PrfA of Listeria monocytogenes results in a loss of virulence due to decreasing DNA-binding affinity.
  6. A novel bile exclusion locus bilE, coordinately regulated by sigmaB and PrfA, represents a new and important virulence factor in L. monocytogenes.
    Title: A PrfA-regulated bile exclusion system (BilE) is a novel virulence factor in Listeria monocytogenes.
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Homology

Names
listeriolysin positive regulatory protein

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003210.1 Reference assembly

    Range
    203640..204353 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_463731.1 listeriolysin positive regulatory protein [Listeria monocytogenes EGD-e]

    See identical proteins and their annotated locations for NP_463731.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0F7QE20, A0A0F7QE26, A0A411JJD1, A0AAD2RBA2, A6P571, D1FKF4, G0YZM5, H6UX14, H6UX15, H6UX18, S5DS96
    Conserved Domains (1) summary
    COG0664
    Location:18 → 210
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
5F1R_A.1
5F1R_B.1
5LEJ_A.1
5LEJ_B.1
P22262.2

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