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AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 [ Homo sapiens (human) ]

Gene ID: 9870, updated on 9-Feb-2020

Summary

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Official Symbol
AREL1provided by HGNC
Official Full Name
apoptosis resistant E3 ubiquitin protein ligase 1provided by HGNC
Primary source
HGNC:HGNC:20363
See related
Ensembl:ENSG00000119682 MIM:615380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FIEL1; KIAA0317
Expression
Ubiquitous expression in testis (RPKM 15.1), thyroid (RPKM 12.5) and 25 other tissues See more
Orthologs
mouse all

Genomic context

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See AREL1 in Genome Data Viewer
Location:
14q24.3
Exon count:
21
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (74661256..74713118, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (75127955..75179807, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370567 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene FCF1 rRNA-processing protein Neighboring gene YLP motif containing 1 Neighboring gene uncharacterized LOC105370569

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4. Lear T, et al. J Exp Med, 2016 May 30. PMID 27162139, Free PMC Article
  2. Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling. Michel MA, et al. Mol Cell, 2017 Oct 5. PMID 28943312, Free PMC Article
  3. Assembly and specific recognition of k29- and k33-linked polyubiquitin. Michel MA, et al. Mol Cell, 2015 Apr 2. PMID 25752577, Free PMC Article
  4. Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS. Kim JB, et al. J Biol Chem, 2013 Apr 26. PMID 23479728, Free PMC Article
  5. Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations. Kristariyanto YA, et al. Biochem J, 2015 Apr 15. PMID 25723849, Free PMC Article

See all (17) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. new protein isoform encoded by KIAA0317, termed fibrosis-inducing E3 ligase 1 (FIEL1), which potently stimulates the TGFbeta signaling pathway through the site-specific ubiquitination of PIAS4.
    Title: Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4.
  2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0317

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
  
negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
positive regulation of protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
apoptosis-resistant E3 ubiquitin protein ligase 1
Names
apoptosis-resistant HECT-type E3 ubiquitin transferase 1
fibrosis-inducing E3 ligase 1
NP_001034568.1
XP_005268301.1
XP_006720407.1
XP_011535717.1
XP_011535718.1
XP_011535719.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039479.2 → NP_001034568.1  apoptosis-resistant E3 ubiquitin protein ligase 1

    See identical proteins and their annotated locations for NP_001034568.1

    Status: VALIDATED

    Source sequence(s)
    AB002315, AC007956, BC032944, BI459956
    Consensus CDS
    CCDS41971.1
    UniProtKB/Swiss-Prot
    O15033
    Related
    ENSP00000348714.4, ENST00000356357.9
    Conserved Domains (2) summary
    smart00119
    Location:486 → 820
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00630
    Location:56 → 154
    Filamin; Filamin/ABP280 repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    74661256..74713118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268244.3 → XP_005268301.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X4

    See identical proteins and their annotated locations for XP_005268301.1

    Related
    ENSP00000452101.1, ENST00000556202.5
    Conserved Domains (1) summary
    smart00119
    Location:325 → 659
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

  2. XM_006720344.3 → XP_006720407.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X2

    See identical proteins and their annotated locations for XP_006720407.1

    Conserved Domains (2) summary
    smart00119
    Location:476 → 810
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00630
    Location:56 → 144
    Filamin; Filamin/ABP280 repeat

  3. XM_011537416.3 → XP_011535718.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X3

    See identical proteins and their annotated locations for XP_011535718.1

    Conserved Domains (3) summary
    smart00119
    Location:486 → 760
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:464 → 761
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00630
    Location:56 → 154
    Filamin; Filamin/ABP280 repeat

  4. XM_011537417.2 → XP_011535719.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X4

    See identical proteins and their annotated locations for XP_011535719.1

    Conserved Domains (1) summary
    smart00119
    Location:325 → 659
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

  5. XM_011537415.2 → XP_011535717.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1

    See identical proteins and their annotated locations for XP_011535717.1

    UniProtKB/Swiss-Prot
    O15033
    Conserved Domains (2) summary
    smart00119
    Location:486 → 820
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00630
    Location:56 → 154
    Filamin; Filamin/ABP280 repeat

RNA

  1. XR_001750615.2 RNA Sequence

    Related
    ENST00000469797.5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_014821.2: Suppressed sequence

    Description
    NM_014821.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15033.3 GenPept UniProtKB/Swiss-Prot:O15033

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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