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TOMM70 translocase of outer mitochondrial membrane 70 [ Homo sapiens (human) ]

Gene ID: 9868, updated on 9-Feb-2020

Summary

Official Symbol
TOMM70provided by HGNC
Official Full Name
translocase of outer mitochondrial membrane 70provided by HGNC
Primary source
HGNC:HGNC:11985
See related
Ensembl:ENSG00000154174 MIM:606081
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Tom70; TOMM70A
Summary
This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in brain (RPKM 23.1), thyroid (RPKM 20.6) and 25 other tissues See more
Orthologs

Genomic context

See TOMM70 in Genome Data Viewer
Location:
3q12.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (100363431..100401089, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (100082303..100120242, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 23 Neighboring gene nitrilase family member 2 Neighboring gene leukemia NUP98 fusion partner 1 Neighboring gene transmembrane protein 45A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of translocase of outer mitochondrial membrane 70 homolog A (TOMM70A) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ90470

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
macroautophagy TAS
Traceable Author Statement
more info
 
protein targeting to mitochondrion TAS
Traceable Author Statement
more info
PubMed 
protein transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
mitochondrial outer membrane translocase complex TAS
Traceable Author Statement
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitochondrial import receptor subunit TOM70
Names
mitochondrial precursor proteins import receptor
translocase of outer membrane 70 kDa subunit
translocase of outer mitochondrial membrane 70 homolog A
translocase of outer mitochondrial membrane protein 70

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014820.5NP_055635.3  mitochondrial import receptor subunit TOM70

    See identical proteins and their annotated locations for NP_055635.3

    Status: REVIEWED

    Source sequence(s)
    AB018262, AC093003, AW044465, BC065555
    Consensus CDS
    CCDS33807.1
    UniProtKB/Swiss-Prot
    O94826
    Related
    ENSP00000284320.5, ENST00000284320.6
    Conserved Domains (3) summary
    TIGR00990
    Location:41601
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:114142
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:114146
    TPR_1; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    100363431..100401089 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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