U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TOMM70 translocase of outer mitochondrial membrane 70 [ Homo sapiens (human) ]

Gene ID: 9868, updated on 6-Nov-2022

Summary

Official Symbol
TOMM70provided by HGNC
Official Full Name
translocase of outer mitochondrial membrane 70provided by HGNC
Primary source
HGNC:HGNC:11985
See related
Ensembl:ENSG00000154174 MIM:606081; AllianceGenome:HGNC:11985
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Tom70; TOMM70A
Summary
This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins. The protein interacts with the SARS-CoV and SARS-Cov-2 ORF9b proteins. [provided by RefSeq, Dec 2021]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection.
Expression
Ubiquitous expression in brain (RPKM 23.1), thyroid (RPKM 20.6) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TOMM70 in Genome Data Viewer
Location:
3q12.2
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (100363431..100401089, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (103068774..103106448, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (100082275..100119933, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 23 Neighboring gene Sharpr-MPRA regulatory region 4023 Neighboring gene nitrilase family member 2 Neighboring gene leukemia NUP98 fusion partner 1 Neighboring gene transmembrane protein 45A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of translocase of outer mitochondrial membrane 70 homolog A (TOMM70A) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ90470

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mitochondrion targeting sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mitochondrion targeting sequence binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to protein transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell growth involved in cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of defense response to virus by host IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interferon-beta production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein import IEA
Inferred from Electronic Annotation
more info
 
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein import into mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein insertion into mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein insertion into mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein insertion into mitochondrial outer membrane IC
Inferred by Curator
more info
PubMed 
involved_in protein targeting to mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein targeting to mitochondrion TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to thyroxine IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mitochondrial import receptor subunit TOM70
Names
mitochondrial precursor proteins import receptor
translocase of outer membrane 70 kDa subunit
translocase of outer mitochondrial membrane 70 homolog A
translocase of outer mitochondrial membrane protein 70

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014820.5NP_055635.3  mitochondrial import receptor subunit TOM70

    See identical proteins and their annotated locations for NP_055635.3

    Status: REVIEWED

    Source sequence(s)
    AB018262, AC093003, AW044465, BC065555
    Consensus CDS
    CCDS33807.1
    UniProtKB/Swiss-Prot
    D3DN48, O94826
    Related
    ENSP00000284320.5, ENST00000284320.6
    Conserved Domains (2) summary
    TIGR00990
    Location:41601
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:114142
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    100363431..100401089 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    103068774..103106448 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)