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Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide [ Mus musculus (house mouse) ]

Gene ID: 98660, updated on 8-Feb-2024

Summary

Official Symbol
Atp1a2provided by MGI
Official Full Name
ATPase, Na+/K+ transporting, alpha 2 polypeptideprovided by MGI
Primary source
MGI:MGI:88106
See related
Ensembl:ENSMUSG00000007097 AllianceGenome:MGI:88106
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Atpa-3; mKIAA0778
Summary
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and alkali metal ion binding activity. Involved in several processes, including cellular response to steroid hormone stimulus; locomotory exploration behavior; and response to auditory stimulus. Acts upstream of or within several processes, including forebrain development; regulation of blood circulation; and regulation of muscle contraction. Located in T-tubule; cell projection; and neuronal cell body. Is expressed in several structures, including genitourinary system; heart; musculature; nervous system; and sensory organ. Used to study familial hemiplegic migraine 2. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; benign neonatal seizures; familial hemiplegic migraine 2; hypertension; and migraine with aura. Orthologous to human ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 126.7), frontal lobe adult (RPKM 118.1) and 14 other tissues See more
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Genomic context

See Atp1a2 in Genome Data Viewer
Location:
1 H3; 1 79.6 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (172099276..172125631, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (172271709..172298064, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 17224 Neighboring gene STARR-positive B cell enhancer ABC_E630 Neighboring gene calsequestrin 1 Neighboring gene ATPase, Na+/K+ transporting, alpha 4 polypeptide Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_03056 Neighboring gene predicted gene, 57554 Neighboring gene STARR-positive B cell enhancer mm9_chr1:174207398-174207699 Neighboring gene predicted gene, 39704 Neighboring gene STARR-positive B cell enhancer ABC_E5853 Neighboring gene STARR-positive B cell enhancer ABC_E11698 Neighboring gene immunoglobulin superfamily, member 8 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables ATPase-coupled monoatomic cation transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables P-type potassium transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables P-type sodium:potassium-exchanging transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables P-type sodium:potassium-exchanging transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables potassium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables sodium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables steroid binding ISO
Inferred from Sequence Orthology
more info
 
enables steroid hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ATP metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within L-ascorbic acid metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within amygdala development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood circulation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to steroid hormone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to steroid hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular potassium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular potassium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular sodium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular sodium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within locomotion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in locomotory exploration behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within membrane depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monoatomic cation transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of striated muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuronal action potential propagation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neurotransmitter uptake IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within olfactory cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in proton transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proton transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of blood pressure IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of cardiac muscle cell contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of respiratory gaseous exchange by nervous system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of striated muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of the force of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of vasoconstriction IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to auditory stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to glycoside IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to glycoside ISO
Inferred from Sequence Orthology
more info
 
involved_in response to nicotine ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to potassium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sodium ion export across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sodium ion export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in T-tubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
located_in caveola ISO
Inferred from Sequence Orthology
more info
 
is_active_in cell projection IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell projection IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in intercalated disc ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in organelle membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 
part_of sodium:potassium-exchanging ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of sodium:potassium-exchanging ATPase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sodium/potassium-transporting ATPase subunit alpha-2
Names
Na(+)/K(+) ATPase alpha(+) subunit
Na(+)/K(+) ATPase alpha-2 subunit
sodium pump subunit alpha-2
NP_848492.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178405.3NP_848492.1  sodium/potassium-transporting ATPase subunit alpha-2

    See identical proteins and their annotated locations for NP_848492.1

    Status: VALIDATED

    Source sequence(s)
    AC087061, AK147331, BY780072
    Consensus CDS
    CCDS35782.1
    UniProtKB/Swiss-Prot
    Q6PIE5, Q80UZ8
    UniProtKB/TrEMBL
    Q3UHK5, Q6ZQ49
    Related
    ENSMUSP00000083077.5, ENSMUST00000085913.11
    Conserved Domains (1) summary
    TIGR01106
    Location:301020
    ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    172099276..172125631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)