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CEP170 centrosomal protein 170 [ Homo sapiens (human) ]

Gene ID: 9859, updated on 10-Oct-2019

Summary

Official Symbol
CEP170provided by HGNC
Official Full Name
centrosomal protein 170provided by HGNC
Primary source
HGNC:HGNC:28920
See related
Ensembl:ENSG00000143702 MIM:613023
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KAB; FAM68A; KIAA0470
Summary
The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 12.9), testis (RPKM 11.4) and 23 other tissues See more
Orthologs

Genomic context

See CEP170 in Genome Data Viewer
Location:
1q43
Exon count:
23
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (243124428..243255796, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (243287730..243419284, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene nascent polypeptide-associated complex subunit alpha, muscle-specific form-like Neighboring gene long intergenic non-protein coding RNA 1347 Neighboring gene RNA, U6 small nuclear 747, pseudogene Neighboring gene serologically defined colon cancer antigen 8 Neighboring gene FCF1 pseudogene 7 Neighboring gene microRNA 4677

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
NHGRI GWA Catalog
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
NHGRI GWA Catalog
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV Vif interacts with CEP170 PubMed
Vpr vpr HIV-1 Vpr is identified to have a physical interaction with centrosomal protein 170kDa (CEP170) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
centriolar subdistal appendage IDA
Inferred from Direct Assay
more info
PubMed 
centriole IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
centrosomal protein of 170 kDa
Names
KARP-1-binding protein
XRCC5 binding protein
centrosomal protein 170kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029663.2 RefSeqGene

    Range
    5126..135979
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042404.1NP_001035863.1  centrosomal protein of 170 kDa isoform beta

    See identical proteins and their annotated locations for NP_001035863.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta, also known as 2) lacks an alternate in-frame exon, compared to variant alpha, resulting in a shorter protein (isoform beta), compared to isoform alpha.
    Source sequence(s)
    AB022658, AC092782, AL606534, BP349206, BP349680, CB410835
    Consensus CDS
    CCDS44337.1
    UniProtKB/Swiss-Prot
    Q5SW79
    Related
    ENSP00000355502.1, ENST00000366544.5
    Conserved Domains (3) summary
    COG1716
    Location:1290
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:7131408
    CEP170_C; CEP170 C-terminus
  2. NM_001042405.1NP_001035864.1  centrosomal protein of 170 kDa isoform gamma

    See identical proteins and their annotated locations for NP_001035864.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (gamma, also known as 3) has multiple differences in the coding region but maintains the reading frame, compared to variant alpha, resulting in a shorter protein (isoform gamma), compared to isoform alpha.
    Source sequence(s)
    AB022659, AC092782, BP349206, BP349680, CB410835
    Consensus CDS
    CCDS44338.1
    UniProtKB/Swiss-Prot
    Q5SW79
    Related
    ENSP00000355501.1, ENST00000366543.5
    Conserved Domains (3) summary
    COG1716
    Location:1290
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:7131382
    CEP170_C; CEP170 C-terminus
  3. NM_014812.3NP_055627.2  centrosomal protein of 170 kDa isoform alpha

    See identical proteins and their annotated locations for NP_055627.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha, also known as 1) represents the longest transcript and encodes the longest isoform (alpha).
    Source sequence(s)
    AB022657, AC092782, AL606534, BP349206, BP349680, CB410835
    Consensus CDS
    CCDS44339.1
    UniProtKB/Swiss-Prot
    Q5SW79
    Related
    ENSP00000355500.1, ENST00000366542.6
    Conserved Domains (4) summary
    pfam09528
    Location:353854
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:1290
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:8111506
    CEP170_C; CEP170 C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    243124428..243255796 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544341.3XP_011542643.1  centrosomal protein of 170 kDa isoform X6

    See identical proteins and their annotated locations for XP_011542643.1

    Conserved Domains (4) summary
    pfam09528
    Location:353854
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:1290
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:8111516
    CEP170_C; CEP170 C-terminus
  2. XM_017002942.2XP_016858431.1  centrosomal protein of 170 kDa isoform X12

  3. XM_017002938.2XP_016858427.1  centrosomal protein of 170 kDa isoform X11

  4. XM_017002937.2XP_016858426.1  centrosomal protein of 170 kDa isoform X10

  5. XM_017002935.2XP_016858424.1  centrosomal protein of 170 kDa isoform X9

  6. XM_011544337.3XP_011542639.1  centrosomal protein of 170 kDa isoform X2

    See identical proteins and their annotated locations for XP_011542639.1

    Conserved Domains (4) summary
    pfam09528
    Location:466916
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:1290
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:8731568
    CEP170_C; CEP170 C-terminus
  7. XM_011544334.3XP_011542636.1  centrosomal protein of 170 kDa isoform X1

    See identical proteins and their annotated locations for XP_011542636.1

    Conserved Domains (4) summary
    pfam09528
    Location:466916
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:1290
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:8731578
    CEP170_C; CEP170 C-terminus
  8. XM_017002943.2XP_016858432.1  centrosomal protein of 170 kDa isoform X12

  9. XM_011544339.3XP_011542641.1  centrosomal protein of 170 kDa isoform X5

    See identical proteins and their annotated locations for XP_011542641.1

    Conserved Domains (4) summary
    pfam09528
    Location:466916
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:1290
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:8731542
    CEP170_C; CEP170 C-terminus
  10. XM_011544338.3XP_011542640.1  centrosomal protein of 170 kDa isoform X4

    See identical proteins and their annotated locations for XP_011542640.1

    Conserved Domains (4) summary
    pfam09528
    Location:466916
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:1290
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:8731551
    CEP170_C; CEP170 C-terminus
  11. XM_017002948.2XP_016858437.1  centrosomal protein of 170 kDa isoform X17

  12. XM_017002944.2XP_016858433.1  centrosomal protein of 170 kDa isoform X14

    Conserved Domains (3) summary
    COG1716
    Location:1290
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:7131418
    CEP170_C; CEP170 C-terminus
  13. XM_017002939.2XP_016858428.1  centrosomal protein of 170 kDa isoform X9

  14. XM_017002941.2XP_016858430.1  centrosomal protein of 170 kDa isoform X10

  15. XM_017002933.2XP_016858422.1  centrosomal protein of 170 kDa isoform X6

    Conserved Domains (4) summary
    pfam09528
    Location:353854
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:1290
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:8111516
    CEP170_C; CEP170 C-terminus
  16. XM_006711843.4XP_006711906.1  centrosomal protein of 170 kDa isoform X1

    See identical proteins and their annotated locations for XP_006711906.1

    Related
    ENSP00000338161.4, ENST00000336415.8
    Conserved Domains (4) summary
    pfam09528
    Location:466916
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:1290
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:8731578
    CEP170_C; CEP170 C-terminus
  17. XM_017002951.2XP_016858440.1  centrosomal protein of 170 kDa isoform X20

  18. XM_017002950.2XP_016858439.1  centrosomal protein of 170 kDa isoform X19

  19. XM_017002946.2XP_016858435.1  centrosomal protein of 170 kDa isoform X16

  20. XM_011544343.3XP_011542645.1  centrosomal protein of 170 kDa isoform X13

    See identical proteins and their annotated locations for XP_011542645.1

    Conserved Domains (4) summary
    pfam09528
    Location:307757
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:1290
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:7141419
    CEP170_C; CEP170 C-terminus
  21. XM_017002949.2XP_016858438.1  centrosomal protein of 170 kDa isoform X18

  22. XM_017002947.2XP_016858436.1  centrosomal protein of 170 kDa isoform X17

  23. XM_017002945.2XP_016858434.1  centrosomal protein of 170 kDa isoform X15

  24. XM_011544344.3XP_011542646.1  centrosomal protein of 170 kDa isoform X14

    See identical proteins and their annotated locations for XP_011542646.1

    Conserved Domains (3) summary
    COG1716
    Location:1290
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:7131418
    CEP170_C; CEP170 C-terminus
  25. XM_011544342.3XP_011542644.1  centrosomal protein of 170 kDa isoform X7

    See identical proteins and their annotated locations for XP_011542644.1

    Conserved Domains (4) summary
    pfam09528
    Location:466916
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:1290
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:8731515
    CEP170_C; CEP170 C-terminus
  26. XM_011544340.3XP_011542642.1  centrosomal protein of 170 kDa isoform X3

    See identical proteins and their annotated locations for XP_011542642.1

    Conserved Domains (4) summary
    pfam09528
    Location:466916
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:1290
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:8731532
    CEP170_C; CEP170 C-terminus
  27. XM_017002940.2XP_016858429.1  centrosomal protein of 170 kDa isoform X9

  28. XM_017002936.2XP_016858425.1  centrosomal protein of 170 kDa isoform X8

    UniProtKB/Swiss-Prot
    Q5SW79
    Conserved Domains (4) summary
    pfam09528
    Location:353854
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:1290
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:8111506
    CEP170_C; CEP170 C-terminus
  29. XM_017002934.2XP_016858423.1  centrosomal protein of 170 kDa isoform X6

    Conserved Domains (4) summary
    pfam09528
    Location:353854
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:1290
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:8111516
    CEP170_C; CEP170 C-terminus
  30. XM_011544335.3XP_011542637.1  centrosomal protein of 170 kDa isoform X1

    See identical proteins and their annotated locations for XP_011542637.1

    Conserved Domains (4) summary
    pfam09528
    Location:466916
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:1290
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:8731578
    CEP170_C; CEP170 C-terminus
  31. XM_011544336.2XP_011542638.1  centrosomal protein of 170 kDa isoform X1

    See identical proteins and their annotated locations for XP_011542638.1

    Conserved Domains (4) summary
    pfam09528
    Location:466916
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:1290
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:8731578
    CEP170_C; CEP170 C-terminus
  32. XM_017002932.1XP_016858421.1  centrosomal protein of 170 kDa isoform X1

    Conserved Domains (4) summary
    pfam09528
    Location:466916
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:1290
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:8731578
    CEP170_C; CEP170 C-terminus

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187519.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    136536..267514 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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