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PPP1R26 protein phosphatase 1 regulatory subunit 26 [ Homo sapiens (human) ]

Gene ID: 9858, updated on 13-May-2022

Summary

Official Symbol
PPP1R26provided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 26provided by HGNC
Primary source
HGNC:HGNC:29089
See related
Ensembl:ENSG00000196422 MIM:614056; AllianceGenome:HGNC:29089
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NRBE3; KIAA0649
Summary
Predicted to enable protein phosphatase inhibitor activity. Predicted to be involved in negative regulation of phosphatase activity. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 4.1), kidney (RPKM 3.8) and 24 other tissues See more
Orthologs
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Genomic context

See PPP1R26 in Genome Data Viewer
Location:
9q34.3
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (135479066..135488892)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (147707855..147716965)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (138371628..138380738)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene suppressor of cytokine signaling 5 pseudogene 2 Neighboring gene PPP1R26 antisense RNA 1 Neighboring gene piercer of microtubule wall 1 Neighboring gene uncharacterized LOC101928525 Neighboring gene mitochondrial ribosomal protein S2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0649

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in negative regulation of phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 26
Names
1A6/DRIM (down-regulated in metastasis) interacting protein
DRIM/UTP20 interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014811.5NP_055626.3  protein phosphatase 1 regulatory subunit 26

    See identical proteins and their annotated locations for NP_055626.3

    Status: VALIDATED

    Source sequence(s)
    AL161452
    Consensus CDS
    CCDS6988.1
    UniProtKB/Swiss-Prot
    Q5T8A7
    Related
    ENSP00000349274.2, ENST00000356818.7
    Conserved Domains (2) summary
    pfam15740
    Location:1852
    PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
    cl26386
    Location:7621040
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    135479066..135488892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424216.1XP_047280172.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    Related
    ENSP00000385826.3, ENST00000401470.3
  2. XM_017015358.2XP_016870847.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7
    Related
    ENSP00000474807.1, ENST00000605286.5
    Conserved Domains (2) summary
    pfam15740
    Location:1852
    PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
    cl26386
    Location:7621040
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  3. XM_017015360.3XP_016870849.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7
    Conserved Domains (2) summary
    pfam15740
    Location:1852
    PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
    cl26386
    Location:7621040
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  4. XM_047424222.1XP_047280178.1  protein phosphatase 1 regulatory subunit 26 isoform X1

  5. XM_017015361.3XP_016870850.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7
    Conserved Domains (2) summary
    pfam15740
    Location:1852
    PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
    cl26386
    Location:7621040
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  6. XM_047424220.1XP_047280176.1  protein phosphatase 1 regulatory subunit 26 isoform X1

  7. XM_047424224.1XP_047280180.1  protein phosphatase 1 regulatory subunit 26 isoform X1

  8. XM_024447721.2XP_024303489.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    Conserved Domains (2) summary
    pfam15740
    Location:1852
    PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
    cl26386
    Location:7621040
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  9. XM_047424210.1XP_047280166.1  protein phosphatase 1 regulatory subunit 26 isoform X1

  10. XM_017015362.3XP_016870851.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7
    Conserved Domains (2) summary
    pfam15740
    Location:1852
    PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
    cl26386
    Location:7621040
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  11. XM_005263411.3XP_005263468.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    See identical proteins and their annotated locations for XP_005263468.1

    UniProtKB/Swiss-Prot
    Q5T8A7
    Related
    ENSP00000473820.1, ENST00000604351.5
    Conserved Domains (2) summary
    pfam15740
    Location:1852
    PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
    cl26386
    Location:7621040
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  12. XM_047424217.1XP_047280173.1  protein phosphatase 1 regulatory subunit 26 isoform X1

  13. XM_047424223.1XP_047280179.1  protein phosphatase 1 regulatory subunit 26 isoform X1

  14. XM_047424218.1XP_047280174.1  protein phosphatase 1 regulatory subunit 26 isoform X1

  15. XM_047424221.1XP_047280177.1  protein phosphatase 1 regulatory subunit 26 isoform X1

  16. XM_047424212.1XP_047280168.1  protein phosphatase 1 regulatory subunit 26 isoform X1

  17. XM_047424219.1XP_047280175.1  protein phosphatase 1 regulatory subunit 26 isoform X1

  18. XM_017015357.2XP_016870846.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7
    Conserved Domains (2) summary
    pfam15740
    Location:1852
    PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
    cl26386
    Location:7621040
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  19. XM_047424213.1XP_047280169.1  protein phosphatase 1 regulatory subunit 26 isoform X1

  20. XM_017015356.3XP_016870845.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7
    Conserved Domains (2) summary
    pfam15740
    Location:1852
    PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
    cl26386
    Location:7621040
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  21. XM_047424214.1XP_047280170.1  protein phosphatase 1 regulatory subunit 26 isoform X1

  22. XM_047424209.1XP_047280165.1  protein phosphatase 1 regulatory subunit 26 isoform X1

  23. XM_047424215.1XP_047280171.1  protein phosphatase 1 regulatory subunit 26 isoform X1

  24. XM_047424211.1XP_047280167.1  protein phosphatase 1 regulatory subunit 26 isoform X1

  25. XM_017015355.3XP_016870844.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7
    Conserved Domains (2) summary
    pfam15740
    Location:1852
    PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
    cl26386
    Location:7621040
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    147707855..147716965
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)