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Mael maelstrom spermatogenic transposon silencer [ Mus musculus (house mouse) ]

Gene ID: 98558, updated on 8-Feb-2024

Summary

Official Symbol
Maelprovided by MGI
Official Full Name
maelstrom spermatogenic transposon silencerprovided by MGI
Primary source
MGI:MGI:2138453
See related
Ensembl:ENSMUSG00000040629 AllianceGenome:MGI:2138453
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933405K18Rik
Summary
Predicted to enable sequence-specific DNA binding activity. Involved in DNA methylation involved in gamete generation; gene silencing by RNA; and piRNA metabolic process. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; male gamete generation; and negative regulation of macromolecule metabolic process. Located in several cellular components, including chromosome; cytoplasmic ribonucleoprotein granule; and perinuclear region of cytoplasm. Is expressed in brain; early conceptus; and genitourinary system. Orthologous to human MAEL (maelstrom spermatogenic transposon silencer). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 282.2) See more
Orthologs
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Genomic context

See Mael in Genome Data Viewer
Location:
1 H2.3; 1 73.56 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (166028954..166066313, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (166201385..166238744, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene serine/threonine/tyrosine interacting like 2 Neighboring gene STARR-seq mESC enhancer starr_02920 Neighboring gene STARR-positive B cell enhancer ABC_E7772 Neighboring gene glycoprotein A33 transmembrane Neighboring gene STARR-seq mESC enhancer starr_02926 Neighboring gene immunoglobulin-like domain containing receptor 2 Neighboring gene STARR-positive B cell enhancer mm9_chr1:168290436-168290736 Neighboring gene STARR-seq mESC enhancer starr_02930 Neighboring gene STARR-positive B cell enhancer ABC_E11695 Neighboring gene transcriptional adaptor 1 Neighboring gene pogo transposable element with KRAB domain

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of ectopic germ cell programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fertilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in male meiotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within male meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of developmental process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of reproductive process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in piRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in piRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of miRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulatory ncRNA-mediated gene silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in siRNA-mediated retrotransposon silencing by heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in P granule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in P granule IDA
Inferred from Direct Assay
more info
PubMed 
NOT located_in XY body IDA
Inferred from Direct Assay
more info
PubMed 
located_in XY body IDA
Inferred from Direct Assay
more info
PubMed 
located_in autosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatoid body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in piP-body IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein maelstrom homolog
Names
maelstrom homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175296.4NP_780505.1  protein maelstrom homolog

    See identical proteins and their annotated locations for NP_780505.1

    Status: VALIDATED

    Source sequence(s)
    AC034122
    Consensus CDS
    CCDS15448.1
    UniProtKB/Swiss-Prot
    Q8BVN9
    UniProtKB/TrEMBL
    A0A0A6YWQ9
    Related
    ENSMUSP00000045828.4, ENSMUST00000038782.4
    Conserved Domains (2) summary
    pfam09011
    Location:572
    HMG_box_2; HMG-box domain
    pfam13017
    Location:130326
    Maelstrom; piRNA pathway germ-plasm component

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    166028954..166066313 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)