U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TESPA1 thymocyte expressed, positive selection associated 1 [ Homo sapiens (human) ]

Gene ID: 9840, updated on 5-Aug-2022

Summary

Official Symbol
TESPA1provided by HGNC
Official Full Name
thymocyte expressed, positive selection associated 1provided by HGNC
Primary source
HGNC:HGNC:29109
See related
Ensembl:ENSG00000135426 MIM:615664; AllianceGenome:HGNC:29109
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSPC257; ITPRID3; KIAA0748
Summary
Predicted to enable phospholipase binding activity. Predicted to be involved in several processes, including COP9 signalosome assembly; positive regulation of T cell differentiation in thymus; and positive regulation of T cell receptor signaling pathway. Predicted to act upstream of or within TCR signalosome assembly. Part of COP9 signalosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lymph node (RPKM 4.0), brain (RPKM 4.0) and 13 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TESPA1 in Genome Data Viewer
Location:
12q13.2
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (54948015..54985188, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (54914643..54951422, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (55341799..55378546, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene mucin like 1 Neighboring gene small integral membrane protein 10-like protein 1 Neighboring gene uncharacterized LOC107984515 Neighboring gene uncharacterized LOC101927484 Neighboring gene neuronal differentiation 4 Neighboring gene olfactory receptor family 9 subfamily K member 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0748

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phospholipase binding IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in COP9 signalosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in T cell differentiation in thymus IEA
Inferred from Electronic Annotation
more info
 
involved_in TCR signalosome assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of T cell differentiation in thymus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of T cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of COP9 signalosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of TCR signalosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein TESPA1
Names
thymocyte-expressed positive selection-associated protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098815.3NP_001092285.1  protein TESPA1 isoform 1

    See identical proteins and their annotated locations for NP_001092285.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variants 1 and 6, encodes the longest isoform (1).
    Source sequence(s)
    AC079842, BC132732
    Consensus CDS
    CCDS44913.1
    UniProtKB/Swiss-Prot
    A2RU30, Q9P0C4
    UniProtKB/TrEMBL
    A0A024RB73
    Related
    ENSP00000312679.8, ENST00000316577.12
    Conserved Domains (1) summary
    pfam14722
    Location:128286
    KRAP_IP3R_bind; Ki-ras-induced actin-interacting protein-IP3R-interacting domain
  2. NM_001136030.3NP_001129502.1  protein TESPA1 isoform 1

    See identical proteins and their annotated locations for NP_001129502.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variants 2 and 6, encodes the longest isoform (1).
    Source sequence(s)
    AC079842, AK303223, AW967924
    Consensus CDS
    CCDS44913.1
    UniProtKB/Swiss-Prot
    A2RU30, Q9P0C4
    UniProtKB/TrEMBL
    A0A024RB73
    Related
    ENSP00000400892.1, ENST00000449076.6
    Conserved Domains (1) summary
    pfam14722
    Location:128286
    KRAP_IP3R_bind; Ki-ras-induced actin-interacting protein-IP3R-interacting domain
  3. NM_001261844.1NP_001248773.1  protein TESPA1 isoform 2

    See identical proteins and their annotated locations for NP_001248773.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 3 and 5, encodes isoform 2.
    Source sequence(s)
    AB018291, AC079842, AK315972
    Consensus CDS
    CCDS58240.1
    UniProtKB/Swiss-Prot
    A2RU30
    UniProtKB/TrEMBL
    A0A024RB00
    Related
    ENSP00000433098.1, ENST00000531122.5
    Conserved Domains (1) summary
    pfam14722
    Location:2148
    KRAP_IP3R_bind; Ki-ras-induced actin-interacting protein-IP3R-interacting domain
  4. NM_001351148.1NP_001338077.1  protein TESPA1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 3 and 4, encodes isoform 2.
    Source sequence(s)
    AC079842
    Consensus CDS
    CCDS58240.1
    Related
    ENSP00000432030.1, ENST00000532804.5
    Conserved Domains (1) summary
    pfam14722
    Location:2148
    KRAP_IP3R_bind; Ki-ras-induced actin-interacting protein-IP3R-interacting domain
  5. NM_001351149.2NP_001338078.1  protein TESPA1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 1 and 2, encodes the longest isoform (1).
    Source sequence(s)
    AC079842
    Consensus CDS
    CCDS44913.1
    UniProtKB/Swiss-Prot
    Q9P0C4
    Conserved Domains (1) summary
    pfam14722
    Location:128286
    KRAP_IP3R_bind; Ki-ras-induced actin-interacting protein-IP3R-interacting domain
  6. NM_001351150.1NP_001338079.1  protein TESPA1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) encodes isoform 3.
    Source sequence(s)
    AC079842
    Conserved Domains (1) summary
    pfam14722
    Location:177
    KRAP_IP3R_bind; Ki-ras-induced actin-interacting protein-IP3R-interacting domain
  7. NM_001351151.1NP_001338080.1  protein TESPA1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 9-12, encodes isoform 4.
    Source sequence(s)
    AC079842
  8. NM_001351152.1NP_001338081.1  protein TESPA1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 8 and 10-12, encodes isoform 4.
    Source sequence(s)
    AC079842
  9. NM_001351153.1NP_001338082.1  protein TESPA1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 8, 9, 11, and 12, encodes isoform 4.
    Source sequence(s)
    AC079842
  10. NM_001351154.1NP_001338083.1  protein TESPA1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variants 8-10 and 12, encodes isoform 4.
    Source sequence(s)
    AC079842
  11. NM_001351155.1NP_001338084.1  protein TESPA1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variants 8-11, encodes isoform 4.
    Source sequence(s)
    AC079842
  12. NM_014796.2NP_055611.1  protein TESPA1 isoform 2

    See identical proteins and their annotated locations for NP_055611.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 4 and 5, encodes isoform 2.
    Source sequence(s)
    AB018291, AC079842
    Consensus CDS
    CCDS58240.1
    UniProtKB/Swiss-Prot
    A2RU30
    UniProtKB/TrEMBL
    A0A024RB00
    Related
    ENSP00000435622.1, ENST00000524622.5
    Conserved Domains (1) summary
    pfam14722
    Location:2148
    KRAP_IP3R_bind; Ki-ras-induced actin-interacting protein-IP3R-interacting domain

RNA

  1. NR_147062.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079842
  2. NR_147063.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079842
  3. NR_147064.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079842
  4. NR_147065.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079842
  5. NR_147066.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079842
  6. NR_147067.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079842
  7. NR_147068.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079842
  8. NR_147069.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079842
  9. NR_147070.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079842
  10. NR_147071.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079842
  11. NR_147072.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079842
  12. NR_147073.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079842

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    54948015..54985188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429930.1XP_047285886.1  protein TESPA1 isoform X1

    UniProtKB/Swiss-Prot
    Q9P0C4
  2. XM_047429929.1XP_047285885.1  protein TESPA1 isoform X1

    UniProtKB/Swiss-Prot
    Q9P0C4
  3. XM_017020263.2XP_016875752.1  protein TESPA1 isoform X1

    UniProtKB/Swiss-Prot
    A2RU30, Q9P0C4
    UniProtKB/TrEMBL
    A0A024RB73
    Conserved Domains (1) summary
    pfam14722
    Location:128286
    KRAP_IP3R_bind; Ki-ras-induced actin-interacting protein-IP3R-interacting domain
  4. XM_006719715.4XP_006719778.1  protein TESPA1 isoform X1

    See identical proteins and their annotated locations for XP_006719778.1

    UniProtKB/Swiss-Prot
    A2RU30, Q9P0C4
    UniProtKB/TrEMBL
    A0A024RB73
    Conserved Domains (1) summary
    pfam14722
    Location:128286
    KRAP_IP3R_bind; Ki-ras-induced actin-interacting protein-IP3R-interacting domain
  5. XM_011539035.3XP_011537337.1  protein TESPA1 isoform X1

    See identical proteins and their annotated locations for XP_011537337.1

    UniProtKB/Swiss-Prot
    A2RU30, Q9P0C4
    UniProtKB/TrEMBL
    A0A024RB73
    Conserved Domains (1) summary
    pfam14722
    Location:128286
    KRAP_IP3R_bind; Ki-ras-induced actin-interacting protein-IP3R-interacting domain
  6. XM_047429931.1XP_047285887.1  protein TESPA1 isoform X1

    UniProtKB/Swiss-Prot
    Q9P0C4
  7. XM_017020262.2XP_016875751.1  protein TESPA1 isoform X1

    UniProtKB/Swiss-Prot
    A2RU30, Q9P0C4
    UniProtKB/TrEMBL
    A0A024RB73
    Conserved Domains (1) summary
    pfam14722
    Location:128286
    KRAP_IP3R_bind; Ki-ras-induced actin-interacting protein-IP3R-interacting domain
  8. XM_011539037.4XP_011537339.1  protein TESPA1 isoform X1

    See identical proteins and their annotated locations for XP_011537339.1

    UniProtKB/Swiss-Prot
    A2RU30, Q9P0C4
    UniProtKB/TrEMBL
    A0A024RB73
    Conserved Domains (1) summary
    pfam14722
    Location:128286
    KRAP_IP3R_bind; Ki-ras-induced actin-interacting protein-IP3R-interacting domain

RNA

  1. XR_007063147.1 RNA Sequence

  2. XR_007063146.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    54914643..54951422 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)