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LCMT2 leucine carboxyl methyltransferase 2 [ Homo sapiens (human) ]

Gene ID: 9836, updated on 23-Nov-2021

Summary

Official Symbol
LCMT2provided by HGNC
Official Full Name
leucine carboxyl methyltransferase 2provided by HGNC
Primary source
HGNC:HGNC:17558
See related
Ensembl:ENSG00000168806 MIM:611246
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPM2; TYW4
Summary
The protein encoded by this intronless gene belongs to the highly variable methyltransferase superfamily. This gene is the inferred homolog of the Saccharomyces cerevisiae carboxymethyltransferase gene PPM2 that is essential for the synthesis of the hypermodified guanosine Wybutosine (yW). [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See LCMT2 in Genome Data Viewer
Location:
15q15.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (43323649..43330573, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (43615847..43622771, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATP synthase peripheral stalk subunit d pseudogene 1 Neighboring gene transglutaminase 7 Neighboring gene adenosine deaminase like Neighboring gene zinc finger and SCAN domain containing 29 Neighboring gene tubulin gamma complex associated protein 4 Neighboring gene RNA, 7SL, cytoplasmic 487, pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9534, FLJ51321, KIAA0547

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tRNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tRNA methyltransferase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tRNA modification TAS
Traceable Author Statement
more info
 
involved_in wybutosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tRNA wybutosine-synthesizing protein 4
Names
p21WAF1/CIP1 promoter-interacting protein
tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase
tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase
tRNA-Wybutosine-synthesizing protein 4
tRNA-yW synthesizing protein 4
NP_055608.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014793.5NP_055608.2  tRNA wybutosine-synthesizing protein 4

    See identical proteins and their annotated locations for NP_055608.2

    Status: REVIEWED

    Source sequence(s)
    AC009852, BC015949
    Consensus CDS
    CCDS10094.1
    UniProtKB/Swiss-Prot
    O60294
    Related
    ENSP00000307214.5, ENST00000305641.7
    Conserved Domains (2) summary
    pfam13415
    Location:493540
    Kelch_3; Galactose oxidase, central domain
    cl17173
    Location:28197
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    43323649..43330573 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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