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MELK maternal embryonic leucine zipper kinase [ Homo sapiens (human) ]

Gene ID: 9833, updated on 1-Jun-2020

Summary

Official Symbol
MELKprovided by HGNC
Official Full Name
maternal embryonic leucine zipper kinaseprovided by HGNC
Primary source
HGNC:HGNC:16870
See related
Ensembl:ENSG00000165304 MIM:607025
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HPK38
Expression
Broad expression in testis (RPKM 5.2), lymph node (RPKM 4.4) and 14 other tissues See more
Orthologs

Genomic context

See MELK in Genome Data Viewer
Location:
9p13.2
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (36572862..36677683)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (36572859..36677680)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724322 Neighboring gene high mobility group box 3 pseudogene 24 Neighboring gene ring finger protein 38 Neighboring gene mitochondrial ribosomal protein S21 pseudogene 4 Neighboring gene uncharacterized LOC105376030 Neighboring gene microRNA 4475 Neighboring gene microRNA 4540 Neighboring gene paired box 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat-peptide(48-60) inhibits AGC-family kinases (PKB, SGK1, S6K1, MSK1), CAMK-family kinases (CAMK1 and MELK) and a STE family kinase (MKK1) PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0175

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
hemopoiesis ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intrinsic apoptotic signaling pathway in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
neural precursor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
maternal embryonic leucine zipper kinase
Names
pEg3 kinase
protein kinase Eg3
protein kinase PK38
tyrosine-protein kinase MELK
NP_001243614.1
NP_001243616.1
NP_001243617.1
NP_001243618.1
NP_001243619.1
NP_001243620.1
NP_001243621.1
NP_001243622.1
NP_055606.1
XP_011516378.1
XP_011516379.1
XP_011516380.1
XP_011516381.1
XP_011516382.1
XP_011516383.1
XP_011516384.1
XP_011516385.1
XP_011516386.1
XP_011516387.1
XP_011516388.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256685.1NP_001243614.1  maternal embryonic leucine zipper kinase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AI590871, AK299164, BC014039, BP365611, DB368226
    Consensus CDS
    CCDS59123.1
    UniProtKB/Swiss-Prot
    Q14680
    Related
    ENSP00000437804.1, ENST00000541717.4
    Conserved Domains (4) summary
    cd12198
    Location:514608
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:11263
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:281332
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cd14078
    Location:7263
    STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase
  2. NM_001256687.1NP_001243616.1  maternal embryonic leucine zipper kinase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AI590871, AK300761, BC014039, BP365611, DB368226
    Consensus CDS
    CCDS59124.1
    UniProtKB/Swiss-Prot
    Q14680
    Related
    ENSP00000439792.1, ENST00000536860.5
    Conserved Domains (4) summary
    cd12198
    Location:507601
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:11215
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:233284
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cl21453
    Location:7215
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001256688.1NP_001243617.1  maternal embryonic leucine zipper kinase isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two consecutive exons in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AI590871, AK293284, BC014039, BP365611, DB368226
    Consensus CDS
    CCDS59125.1
    UniProtKB/Swiss-Prot
    Q14680
    Related
    ENSP00000445452.1, ENST00000545008.5
    Conserved Domains (4) summary
    cd12198
    Location:484578
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:11192
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:210261
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cl21453
    Location:7192
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001256689.1NP_001243618.1  maternal embryonic leucine zipper kinase isoform 5

    See identical proteins and their annotated locations for NP_001243618.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) initiates translation at an alternate start codon and lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AB183427, AI590871, BP365611, DB368226
    Consensus CDS
    CCDS59126.1
    UniProtKB/Swiss-Prot
    Q14680
    Related
    ENSP00000441596.1, ENST00000543751.5
    Conserved Domains (4) summary
    cd12198
    Location:523617
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:17231
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:249300
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cl21453
    Location:7231
    PKc_like; Protein Kinases, catalytic domain
  5. NM_001256690.1NP_001243619.1  maternal embryonic leucine zipper kinase isoform 6

    See identical proteins and their annotated locations for NP_001243619.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) initiates translation at an alternate start codon and lacks two consecutive exons in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (6) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AB183428, AI590871, BP365611, DB368226
    Consensus CDS
    CCDS59127.1
    UniProtKB/Swiss-Prot
    Q14680
    Related
    ENSP00000443550.1, ENST00000536329.5
    Conserved Domains (4) summary
    cd12198
    Location:484578
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:9192
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:210261
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cl21453
    Location:10192
    PKc_like; Protein Kinases, catalytic domain
  6. NM_001256691.1NP_001243620.1  maternal embryonic leucine zipper kinase isoform 7

    See identical proteins and their annotated locations for NP_001243620.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) initiates translation at an alternate start codon and lacks two exons in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (7) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AI590871, AK293423, BP365611, DB368226, W01871
    UniProtKB/TrEMBL
    B7Z1G6
    Conserved Domains (4) summary
    cd12198
    Location:475569
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:17183
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:201252
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cl21453
    Location:7183
    PKc_like; Protein Kinases, catalytic domain
  7. NM_001256692.1NP_001243621.1  maternal embryonic leucine zipper kinase isoform 8

    See identical proteins and their annotated locations for NP_001243621.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks three exons in the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (8) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AI590871, AK302374, BP365611, DB368226
    Consensus CDS
    CCDS59128.1
    UniProtKB/Swiss-Prot
    Q14680
    Related
    ENSP00000439184.1, ENST00000536987.5
    Conserved Domains (4) summary
    cd12198
    Location:424518
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:5132
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:150201
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cl21453
    Location:5132
    PKc_like; Protein Kinases, catalytic domain
  8. NM_001256693.1NP_001243622.1  maternal embryonic leucine zipper kinase isoform 9

    See identical proteins and their annotated locations for NP_001243622.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks two consecutive exons in the 5' region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (9) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AI590871, AK301131, BP365611, DB368226, W01871
    UniProtKB/Swiss-Prot
    Q14680
    Conserved Domains (3) summary
    cd12198
    Location:361455
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    cd14341
    Location:87138
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cl21453
    Location:169
    PKc_like; Protein Kinases, catalytic domain
  9. NM_014791.4NP_055606.1  maternal embryonic leucine zipper kinase isoform 1

    See identical proteins and their annotated locations for NP_055606.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AI590871, D79997, DB368226
    Consensus CDS
    CCDS6606.1
    UniProtKB/Swiss-Prot
    Q14680
    Related
    ENSP00000298048.2, ENST00000298048.7
    Conserved Domains (4) summary
    cd12198
    Location:555649
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:11263
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:281332
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cd14078
    Location:7263
    STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase

RNA

  1. NR_046337.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) lacks an internal exon and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI590871, AK296820, BC014039, BP365611, DB368226
    Related
    ENST00000627766.2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    36572862..36677683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518077.1XP_011516379.1  maternal embryonic leucine zipper kinase isoform X1

    See identical proteins and their annotated locations for XP_011516379.1

    UniProtKB/Swiss-Prot
    Q14680
    Conserved Domains (4) summary
    cd12198
    Location:555649
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:11263
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:281332
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cd14078
    Location:7263
    STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase
  2. XM_011518078.2XP_011516380.1  maternal embryonic leucine zipper kinase isoform X1

    See identical proteins and their annotated locations for XP_011516380.1

    UniProtKB/Swiss-Prot
    Q14680
    Conserved Domains (4) summary
    cd12198
    Location:555649
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:11263
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:281332
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cd14078
    Location:7263
    STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase
  3. XM_011518083.2XP_011516385.1  maternal embryonic leucine zipper kinase isoform X3

    See identical proteins and their annotated locations for XP_011516385.1

    UniProtKB/Swiss-Prot
    Q14680
    Conserved Domains (4) summary
    cd12198
    Location:523617
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:17231
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:249300
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cl21453
    Location:7231
    PKc_like; Protein Kinases, catalytic domain
  4. XM_011518076.2XP_011516378.1  maternal embryonic leucine zipper kinase isoform X1

    See identical proteins and their annotated locations for XP_011516378.1

    UniProtKB/Swiss-Prot
    Q14680
    Conserved Domains (4) summary
    cd12198
    Location:555649
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:11263
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:281332
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cd14078
    Location:7263
    STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase
  5. XM_011518082.2XP_011516384.1  maternal embryonic leucine zipper kinase isoform X3

    See identical proteins and their annotated locations for XP_011516384.1

    UniProtKB/Swiss-Prot
    Q14680
    Conserved Domains (4) summary
    cd12198
    Location:523617
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:17231
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:249300
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cl21453
    Location:7231
    PKc_like; Protein Kinases, catalytic domain
  6. XM_011518081.2XP_011516383.1  maternal embryonic leucine zipper kinase isoform X3

    See identical proteins and their annotated locations for XP_011516383.1

    UniProtKB/Swiss-Prot
    Q14680
    Conserved Domains (4) summary
    cd12198
    Location:523617
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:17231
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:249300
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cl21453
    Location:7231
    PKc_like; Protein Kinases, catalytic domain
  7. XM_011518080.1XP_011516382.1  maternal embryonic leucine zipper kinase isoform X2

    Conserved Domains (3) summary
    cd12198
    Location:526620
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:11263
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14078
    Location:7263
    STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase
  8. XM_011518086.2XP_011516388.1  maternal embryonic leucine zipper kinase isoform X5

    Conserved Domains (3) summary
    smart00220
    Location:11263
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:281332
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cd14078
    Location:7263
    STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase
  9. XM_011518085.1XP_011516387.1  maternal embryonic leucine zipper kinase isoform X4

    Conserved Domains (4) summary
    cd12198
    Location:472566
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:1180
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:198249
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cl21453
    Location:1180
    PKc_like; Protein Kinases, catalytic domain
  10. XM_011518079.1XP_011516381.1  maternal embryonic leucine zipper kinase isoform X1

    See identical proteins and their annotated locations for XP_011516381.1

    UniProtKB/Swiss-Prot
    Q14680
    Conserved Domains (4) summary
    cd12198
    Location:555649
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:11263
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:281332
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cd14078
    Location:7263
    STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase
  11. XM_011518084.2XP_011516386.1  maternal embryonic leucine zipper kinase isoform X3

    See identical proteins and their annotated locations for XP_011516386.1

    UniProtKB/Swiss-Prot
    Q14680
    Conserved Domains (4) summary
    cd12198
    Location:523617
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:17231
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:249300
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cl21453
    Location:7231
    PKc_like; Protein Kinases, catalytic domain
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