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TRIM14 tripartite motif containing 14 [ Homo sapiens (human) ]

Gene ID: 9830, updated on 7-Jun-2020

Summary

Official Symbol
TRIM14provided by HGNC
Official Full Name
tripartite motif containing 14provided by HGNC
Primary source
HGNC:HGNC:16283
See related
Ensembl:ENSG00000106785 MIM:606556
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Expression
Ubiquitous expression in colon (RPKM 8.0), small intestine (RPKM 7.7) and 24 other tissues See more
Orthologs

Genomic context

See TRIM14 in Genome Data Viewer
Location:
9q22.33
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (98072014..98119420, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (100798071..100881695, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene acidic nuclear phosphoprotein 32 family member B Neighboring gene RNA, U6 small nuclear 918, pseudogene Neighboring gene N-acetylneuraminate synthase Neighboring gene coronin 2A Neighboring gene TBC1 domain family member 2 Neighboring gene microRNA 6854

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0129

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of viral transcription IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of viral entry into host cell IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tripartite motif-containing protein 14
Names
tripartite motif protein TRIM14

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014788.4NP_055603.2  tripartite motif-containing protein 14

    See identical proteins and their annotated locations for NP_055603.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AA469446, AK292825, AL137073, BF797334
    Consensus CDS
    CCDS6734.1
    UniProtKB/Swiss-Prot
    Q14142
    UniProtKB/TrEMBL
    A0A024R165
    Related
    ENSP00000344208.2, ENST00000341469.7
    Conserved Domains (1) summary
    cd13738
    Location:269441
    SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)
  2. NM_033219.3NP_150088.1  tripartite motif-containing protein 14

    See identical proteins and their annotated locations for NP_150088.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also referred to as alpha) is alternatively spliced in the 3' UTR, compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AA469446, AF220130, AL137073, BF797334
    Consensus CDS
    CCDS6734.1
    UniProtKB/Swiss-Prot
    Q14142
    UniProtKB/TrEMBL
    A0A024R165
    Related
    ENSP00000343990.3, ENST00000342043.3
    Conserved Domains (1) summary
    cd13738
    Location:269441
    SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    98072014..98119420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015352.2XP_016870841.1  tripartite motif-containing protein 14 isoform X1

    UniProtKB/Swiss-Prot
    Q14142
    UniProtKB/TrEMBL
    A0A024R165
    Conserved Domains (1) summary
    cd13738
    Location:269441
    SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)
  2. XM_017015353.2XP_016870842.1  tripartite motif-containing protein 14 isoform X1

    UniProtKB/Swiss-Prot
    Q14142
    UniProtKB/TrEMBL
    A0A024R165
    Conserved Domains (1) summary
    cd13738
    Location:269441
    SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)
  3. XM_005252320.4XP_005252377.1  tripartite motif-containing protein 14 isoform X1

    See identical proteins and their annotated locations for XP_005252377.1

    UniProtKB/Swiss-Prot
    Q14142
    UniProtKB/TrEMBL
    A0A024R165
    Conserved Domains (1) summary
    cd13738
    Location:269441
    SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)
  4. XM_011519244.2XP_011517546.1  tripartite motif-containing protein 14 isoform X4

    Conserved Domains (1) summary
    cd13738
    Location:112284
    SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)
  5. XM_006717338.2XP_006717401.1  tripartite motif-containing protein 14 isoform X2

    See identical proteins and their annotated locations for XP_006717401.1

    Conserved Domains (1) summary
    cd13738
    Location:219391
    SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)
  6. XM_017015354.1XP_016870843.1  tripartite motif-containing protein 14 isoform X3

RNA

  1. XR_929880.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_033220.1: Suppressed sequence

    Description
    NM_033220.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
  2. NM_033221.1: Suppressed sequence

    Description
    NM_033221.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which aligns with poorly supported non-consensus splice sites in the 3' coding region.
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