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ARHGEF17 Rho guanine nucleotide exchange factor 17 [ Homo sapiens (human) ]

Gene ID: 9828, updated on 7-Jun-2020

Summary

Official Symbol
ARHGEF17provided by HGNC
Official Full Name
Rho guanine nucleotide exchange factor 17provided by HGNC
Primary source
HGNC:HGNC:21726
See related
Ensembl:ENSG00000110237 MIM:617043
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TEM4; RHOGEF17; P164RHOGEF; p164-RhoGEF
Expression
Ubiquitous expression in endometrium (RPKM 12.7), fat (RPKM 10.8) and 24 other tissues See more
Orthologs

Genomic context

See ARHGEF17 in Genome Data Viewer
Location:
11q13.4
Exon count:
24
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (73305961..73369388)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (73019663..73080425)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369382 Neighboring gene pyrimidinergic receptor P2Y6 Neighboring gene uncharacterized LOC100287837 Neighboring gene RELT TNF receptor Neighboring gene family with sequence similarity 168 member A Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 38

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ90019, KIAA0337

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rho guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process TAS
Traceable Author Statement
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
rho guanine nucleotide exchange factor 17
Names
164 kDa Rho-specific guanine-nucleotide exchange factor
Rho guanine nucleotide exchange factor (GEF) 17
Rho-specific guanine-nucleotide exchange factor 164 kDa
tumor endothelial marker 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014786.4NP_055601.2  rho guanine nucleotide exchange factor 17

    See identical proteins and their annotated locations for NP_055601.2

    Status: VALIDATED

    Source sequence(s)
    AI312037, AP000562, AP002761, BC137228, BM684780
    Consensus CDS
    CCDS8221.1
    UniProtKB/Swiss-Prot
    Q96PE2
    Related
    ENSP00000263674.3, ENST00000263674.4
    Conserved Domains (2) summary
    pfam00621
    Location:10701253
    RhoGEF; RhoGEF domain
    cl17171
    Location:12861432
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    73305961..73369388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018623.1XP_016874112.1  rho guanine nucleotide exchange factor 17 isoform X1

  2. XM_017018624.1XP_016874113.1  rho guanine nucleotide exchange factor 17 isoform X2

    Related
    ENSP00000493940.1, ENST00000643371.1

RNA

  1. XR_001748051.1 RNA Sequence

  2. XR_001748052.1 RNA Sequence

  3. XR_950116.2 RNA Sequence

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