Format

Send to:

Choose Destination

RGP1 RGP1 homolog, RAB6A GEF complex partner 1 [ Homo sapiens (human) ]

Gene ID: 9827, updated on 24-Nov-2020

Summary

Official Symbol
RGP1provided by HGNC
Official Full Name
RGP1 homolog, RAB6A GEF complex partner 1provided by HGNC
Primary source
HGNC:HGNC:21965
See related
Ensembl:ENSG00000107185 MIM:615742
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA0258
Expression
Ubiquitous expression in thyroid (RPKM 11.4), kidney (RPKM 9.6) and 25 other tissues See more
Orthologs

Genomic context

See RGP1 in Genome Data Viewer
Location:
9p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (35749287..35758585)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35749277..35753264)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene microRNA 6853 Neighboring gene cAMP responsive element binding protein 3 Neighboring gene glucosylceramidase beta 2 Neighboring gene microseminoprotein, prostate associated Neighboring gene natriuretic peptide receptor 2 Neighboring gene sperm associated antigen 8 Neighboring gene histidine triad nucleotide binding protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of RGP1 retrograde golgi transport homolog (RGP1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0258

Gene Ontology Provided by GOA

Function Evidence Code Pubs
guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
small GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
negative regulation of cellular protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retrograde transport, endosome to Golgi IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RIC1-RGP1 guanyl-nucleotide exchange factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RIC1-RGP1 guanyl-nucleotide exchange factor complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
trans-Golgi network membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
RAB6A-GEF complex partner protein 2
Names
RGP1 retrograde golgi transport homolog
retrograde Golgi transport protein RGP1 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080496.3NP_001073965.2  RAB6A-GEF complex partner protein 2

    See identical proteins and their annotated locations for NP_001073965.2

    Status: VALIDATED

    Source sequence(s)
    AK289566, AL133410
    Consensus CDS
    CCDS47964.2
    UniProtKB/Swiss-Prot
    Q92546
    UniProtKB/TrEMBL
    A8K0K1
    Related
    ENSP00000367318.4, ENST00000378078.5
    Conserved Domains (1) summary
    pfam08737
    Location:91331
    Rgp1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    35749287..35758585
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center