Tmem132a transmembrane protein 132A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem132aprovided by MGI
Official Full Name: transmembrane protein 132Aprovided by MGI
Primary source: MGI:MGI:2147810
See related: Ensembl:ENSMUSG00000024736 AllianceGenome:MGI:2147810
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Orai1; Hspa5bp1; 6720481D13Rik
Summary: Predicted to be involved in negative regulation of programmed cell death. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in several structures, including alimentary system; central nervous system; dorsal root ganglion; genitourinary system; and lung. Orthologous to human TMEM132A (transmembrane protein 132A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cerebellum adult (RPKM 93.6), whole brain E14.5 (RPKM 86.6) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19; 19 A

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (10835193..10847569, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (10857829..10870205, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TMEM132A ensures mouse caudal neural tube closure and regulates integrin-based mesodermal migration.
Title: TMEM132A ensures mouse caudal neural tube closure and regulates integrin-based mesodermal migration.
Markedly attenuated the levels of TMEM132A mRNA.
Title: Transcriptional and post-transcriptional regulation of transmembrane protein 132A.
The novel cell-surface localized glycoprotein, TMEM132A, is regulated by several factors, including GRP78, Sar1, and intracellular calcium, in a post-transcriptional manner.
Title: Characterization of the expression and cell-surface localization of transmembrane protein 132A.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3)
Endonuclease-mediated (2)

General gene information

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Markers

AA958958 (e-PCR)
- UniSTS:160795

R74613 (e-PCR)
- UniSTS:125506

Tmem109 (e-PCR), detects polymorphism
- UniSTS:498257

RH126209 (e-PCR)
- UniSTS:162917

RH125077 (e-PCR)
- UniSTS:161899

Homology

Homologs of the Tmem132a gene: The Tmem132a gene is conserved in human, chimpanzee, dog, cow, rat, and frog.
Orthologs from Annotation Pipeline: 308 organisms have orthologs with human gene Tmem132a
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of Wnt protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein binding	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transmembrane protein 132A

Names: HSPA5-binding protein 1; heat shock 70kDa protein 5 binding protein 1; heat shock protein 5 binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001378918.1 → NP_001365847.1 transmembrane protein 132A isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC132402

Conserved Domains (3) summary

pfam15705
Location:44 → 167

TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term

pfam15706
Location:831 → 896

TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term

pfam16070
Location:404 → 746

TMEM132; Transmembrane protein family 132
NM_133804.2 → NP_598565.2 transmembrane protein 132A isoform 1 precursor

See identical proteins and their annotated locations for NP_598565.2

Status: VALIDATED

Source sequence(s)

AK048556, AK173207, CF729397

Consensus CDS

CCDS29589.1

UniProtKB/Swiss-Prot

Q8BX93, Q922P8

Related

ENSMUSP00000025645.8, ENSMUST00000025645.14

Conserved Domains (3) summary

pfam15705
Location:44 → 167

TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term

pfam15706
Location:830 → 897

TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term

pfam16070
Location:403 → 744

TMEM132; Transmembrane protein family 132