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CKAP5 cytoskeleton associated protein 5 [ Homo sapiens (human) ]

Gene ID: 9793, updated on 8-Jul-2021

Summary

Official Symbol
CKAP5provided by HGNC
Official Full Name
cytoskeleton associated protein 5provided by HGNC
Primary source
HGNC:HGNC:28959
See related
Ensembl:ENSG00000175216 MIM:611142
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TOG; MSPS; TOGp; CHTOG; ch-TOG
Summary
This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in testis (RPKM 29.0), brain (RPKM 23.7) and 25 other tissues See more
Orthologs
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Genomic context

See CKAP5 in Genome Data Viewer
Location:
11p11.2
Exon count:
44
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (46743048..46846280, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (46764598..46867831, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 408 Neighboring gene coagulation factor II, thrombin Neighboring gene microRNA 5582 Neighboring gene small nucleolar RNA, C/D box 67 Neighboring gene LRP4 antisense RNA 1 Neighboring gene LDL receptor related protein 4 Neighboring gene chromosome 11 open reading frame 49 Neighboring gene ATPase Asna1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.
GeneReviews: Not available
New sequence variants associated with bone mineral density.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that CKAP5 gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with CKAP5 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35359, KIAA0097

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding HDA PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables microtubule plus end polymerase IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule plus-end binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribonucleoprotein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA transport ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within centrosome cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in centrosome cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in centrosome duplication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in establishment or maintenance of microtubule cytoskeleton polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in establishment or maintenance of microtubule cytoskeleton polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule depolymerization TAS
Traceable Author Statement
more info
PubMed 
involved_in microtubule polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule polymerization TAS
Traceable Author Statement
more info
PubMed 
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of microtubule nucleation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 
colocalizes_with microtubule cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
colocalizes_with microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with microtubule plus-end IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytoskeleton-associated protein 5
Names
colonic and hepatic tumor over-expressed gene protein
colonic and hepatic tumor overexpressed gene protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029924.1 RefSeqGene

    Range
    5029..108262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001008938.4NP_001008938.1  cytoskeleton-associated protein 5 isoform a

    See identical proteins and their annotated locations for NP_001008938.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC115088, BC120869, BM980015, BP282525, CB052595, D43948
    Consensus CDS
    CCDS31477.1
    UniProtKB/Swiss-Prot
    Q14008
    Related
    ENSP00000432768.1, ENST00000529230.6
  2. NM_014756.4NP_055571.2  cytoskeleton-associated protein 5 isoform b

    See identical proteins and their annotated locations for NP_055571.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AC115088, BC120869, BM980015, BP282525, CB052595, D43948, X92474
    Consensus CDS
    CCDS7924.1
    UniProtKB/Swiss-Prot
    Q14008
    Related
    ENSP00000310227.5, ENST00000312055.9

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    46743048..46846280 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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