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CKAP5 cytoskeleton associated protein 5 [ Homo sapiens (human) ]

Gene ID: 9793, updated on 9-Aug-2020

Summary

Official Symbol
CKAP5provided by HGNC
Official Full Name
cytoskeleton associated protein 5provided by HGNC
Primary source
HGNC:HGNC:28959
See related
Ensembl:ENSG00000175216 MIM:611142
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TOG; MSPS; TOGp; CHTOG; ch-TOG
Summary
This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in testis (RPKM 29.0), brain (RPKM 23.7) and 25 other tissues See more
Orthologs

Genomic context

See CKAP5 in Genome Data Viewer
Location:
11p11.2
Exon count:
44
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (46743048..46846308, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (46765084..46867859, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 408 Neighboring gene coagulation factor II, thrombin Neighboring gene microRNA 5582 Neighboring gene small nucleolar RNA, C/D box 67 Neighboring gene LRP4 antisense RNA 1 Neighboring gene LDL receptor related protein 4 Neighboring gene chromosome 11 open reading frame 49 Neighboring gene ATPase Asna1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.
NHGRI GWA Catalog
New sequence variants associated with bone mineral density.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that CKAP5 gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with CKAP5 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35359, KIAA0097

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cadherin binding HDA PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule plus end polymerase IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribonucleoprotein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
RNA transport ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
centrosome cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
centrosome duplication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
establishment or maintenance of microtubule cytoskeleton polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment or maintenance of microtubule cytoskeleton polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule depolymerization TAS
Traceable Author Statement
more info
PubMed 
microtubule polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule polymerization TAS
Traceable Author Statement
more info
PubMed 
mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of microtubule nucleation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with gamma-tubulin complex IDA
Inferred from Direct Assay
more info
PubMed 
kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
colocalizes_with microtubule cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
colocalizes_with microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with microtubule plus-end IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytoskeleton-associated protein 5
Names
colonic and hepatic tumor over-expressed gene protein
colonic and hepatic tumor overexpressed gene protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029924.1 RefSeqGene

    Range
    5029..108262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001008938.4NP_001008938.1  cytoskeleton-associated protein 5 isoform a

    See identical proteins and their annotated locations for NP_001008938.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC115088, BC120869, BM980015, BP282525, CB052595, D43948
    Consensus CDS
    CCDS31477.1
    UniProtKB/Swiss-Prot
    Q14008
    Related
    ENSP00000432768.1, ENST00000529230.6
  2. NM_014756.3NP_055571.2  cytoskeleton-associated protein 5 isoform b

    See identical proteins and their annotated locations for NP_055571.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    BC120869, BM980015, BP282525, CB052595, D43948, X92474
    Consensus CDS
    CCDS7924.1
    UniProtKB/Swiss-Prot
    Q14008
    Related
    ENSP00000310227.5, ENST00000312055.9

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    46743048..46846308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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