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RIMS3 regulating synaptic membrane exocytosis 3 [ Homo sapiens (human) ]

Gene ID: 9783, updated on 5-Jul-2025
Official Symbol
RIMS3provided by HGNC
Official Full Name
regulating synaptic membrane exocytosis 3provided by HGNC
Primary source
HGNC:HGNC:21292
See related
Ensembl:ENSG00000117016 MIM:611600; AllianceGenome:HGNC:21292
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NIM3; RIM3; RIM 3
Summary
Predicted to enable transmembrane transporter binding activity. Predicted to be a structural constituent of presynaptic active zone. Predicted to be involved in several processes, including regulated exocytosis; regulation of synapse organization; and regulation of synaptic vesicle exocytosis. Predicted to be located in presynaptic active zone. Predicted to be active in several cellular components, including postsynaptic cytosol; presynaptic active zone cytoplasmic component; and presynaptic membrane. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in brain (RPKM 26.0), adrenal (RPKM 4.0) and 9 other tissues See more
Orthologs
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See RIMS3 in Genome Data Viewer
Location:
1p34.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (40620680..40692066, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (40489861..40544972, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (41086352..41131354, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378673 Neighboring gene general transcription factor IIF subunit 2 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 730 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:41093974-41095173 Neighboring gene uncharacterized LOC105378675 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:41128965-41129622 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 848 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 849 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 850 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 851 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 852 Neighboring gene NFYC antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 733 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:41174578-41175204 Neighboring gene nuclear transcription factor Y subunit gamma Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41180095-41180734 Neighboring gene microRNA 30e Neighboring gene microRNA 30c-1

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • KIAA0237

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of presynaptic active zone IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmembrane transporter binding IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in calcium-ion regulated exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in maintenance of presynaptic active zone structure IEA
Inferred from Electronic Annotation
more info
 
involved_in neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of membrane potential IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of membrane potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of synaptic vesicle exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in synaptic vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in synaptic vesicle priming IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in presynaptic active zone IEA
Inferred from Electronic Annotation
more info
 
located_in presynaptic active zone TAS
Traceable Author Statement
more info
PubMed 
is_active_in presynaptic active zone cytoplasmic component IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
regulating synaptic membrane exocytosis protein 3
Names
RIM3 gamma
Rab-3 interacting molecule 3
rab-3-interacting molecule 3

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014747.3NP_055562.2  regulating synaptic membrane exocytosis protein 3

    See identical proteins and their annotated locations for NP_055562.2

    Status: VALIDATED

    Source sequence(s)
    AL031289
    Consensus CDS
    CCDS30687.1
    UniProtKB/Swiss-Prot
    D3DPV8, Q92511, Q9UJD0, X5D7U7
    Related
    ENSP00000361769.3, ENST00000372684.8
    Conserved Domains (1) summary
    cl14603
    Location:141286
    C2; C2 domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    40620680..40692066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435189.1XP_047291145.1  regulating synaptic membrane exocytosis protein 3 isoform X1

    UniProtKB/Swiss-Prot
    D3DPV8, Q92511, Q9UJD0, X5D7U7
  2. XM_047435184.1XP_047291140.1  regulating synaptic membrane exocytosis protein 3 isoform X1

    UniProtKB/Swiss-Prot
    D3DPV8, Q92511, Q9UJD0, X5D7U7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    40489861..40544972 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339778.1XP_054195753.1  regulating synaptic membrane exocytosis protein 3 isoform X1

    UniProtKB/Swiss-Prot
    D3DPV8, Q92511, Q9UJD0, X5D7U7