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TMEM94 transmembrane protein 94 [ Homo sapiens (human) ]

Gene ID: 9772, updated on 27-Nov-2024

Summary

Official Symbol
TMEM94provided by HGNC
Official Full Name
transmembrane protein 94provided by HGNC
Primary source
HGNC:HGNC:28983
See related
Ensembl:ENSG00000177728 MIM:618163; AllianceGenome:HGNC:28983
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERMA; IDDCDF; KIAA0195
Summary
Enables P-type magnesium transporter activity. Involved in magnesium ion transport from cytosol to endoplasmic reticulum. Is active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in brain (RPKM 13.2), testis (RPKM 12.0) and 25 other tissues See more
Orthologs
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Genomic context

See TMEM94 in Genome Data Viewer
Location:
17q25.1
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (75456635..75500452)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (76350056..76393782)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73452716..73496533)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 6144 Neighboring gene RNA, U6 small nuclear 938, pseudogene Neighboring gene microRNA 3678 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12763 Neighboring gene Sharpr-MPRA regulatory region 2319 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12764 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8967 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:73464760-73464928 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8968 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:73476676-73476860 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12765 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12766 Neighboring gene microRNA 6785 Neighboring gene CASK interacting protein 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73510728-73511294 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8969 Neighboring gene Sharpr-MPRA regulatory region 12010 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8971 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:73521300-73521484 Neighboring gene tRNA splicing endonuclease subunit 54 Neighboring gene LLGL scribble cell polarity complex component 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73537609-73538426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73540787-73541589 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73548510-73549090 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73553000-73553936 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73553937-73554872 Neighboring gene Sharpr-MPRA regulatory region 3602 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12767 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12768 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12769

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ37545, DKFZp781M1056

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables P-type magnesium transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables P-type magnesium transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in intracellular magnesium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in magnesium ion transport from cytosol to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in magnesium ion transport from cytosol to endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transmembrane protein 94; endoplasmic reticulum magnesium-transporting P-type ATPase
Names
ER Mg2+ ATPase
endoplasmic reticulum magnesium ATPase
NP_001308077.1
NP_001308078.1
NP_001338131.1
NP_001338132.1
NP_055553.3
XP_005257921.1
XP_011523816.1
XP_016880922.1
XP_016880923.1
XP_016880924.1
XP_016880925.1
XP_016880926.1
XP_016880927.1
XP_016880928.1
XP_016880929.1
XP_016880931.1
XP_016880932.1
XP_016880933.1
XP_016880935.1
XP_016880937.1
XP_047293114.1
XP_047293115.1
XP_047293116.1
XP_047293117.1
XP_047293118.1
XP_047293119.1
XP_047293120.1
XP_047293121.1
XP_047293122.1
XP_047293123.1
XP_047293124.1
XP_047293125.1
XP_047293126.1
XP_047293127.1
XP_047293128.1
XP_047293129.1
XP_047293130.1
XP_047293131.1
XP_047293132.1
XP_047293133.1
XP_047293134.1
XP_047293135.1
XP_047293136.1
XP_047293137.1
XP_047293138.1
XP_047293139.1
XP_047293140.1
XP_047293141.1
XP_047293142.1
XP_047293143.1
XP_054173956.1
XP_054173957.1
XP_054173958.1
XP_054173959.1
XP_054173960.1
XP_054173961.1
XP_054173962.1
XP_054173963.1
XP_054173964.1
XP_054173965.1
XP_054173966.1
XP_054173967.1
XP_054173968.1
XP_054173969.1
XP_054173970.1
XP_054173971.1
XP_054173972.1
XP_054173973.1
XP_054173974.1
XP_054173975.1
XP_054173976.1
XP_054173977.1
XP_054173978.1
XP_054173979.1
XP_054173980.1
XP_054173981.1
XP_054173982.1
XP_054173983.1
XP_054173984.1
XP_054173985.1
XP_054173986.1
XP_054173987.1
XP_054173988.1
XP_054173989.1
XP_054173990.1
XP_054173991.1
XP_054173992.1
XP_054173993.1
XP_054173994.1
XP_054173995.1
XP_054173996.1
XP_054173997.1
XP_054173998.1
XP_054173999.1
XP_054174000.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054884.1 RefSeqGene

    Range
    20477..64294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001321148.2NP_001308077.1  transmembrane protein 94 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK316060, CN307648, D83779, DB545285, H06743
    Consensus CDS
    CCDS82204.1
    UniProtKB/TrEMBL
    B4DGC6
    Related
    ENSP00000364397.5, ENST00000375248.9
    Conserved Domains (1) summary
    COG0474
    Location:9881339
    MgtA; Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism]
  2. NM_001321149.2NP_001308078.1  transmembrane protein 94 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC100787, CN307648, D83779, DA317199, DB545285, H06743
    Consensus CDS
    CCDS92394.1
    UniProtKB/TrEMBL
    J3KRN3, J3QSG7
    Related
    ENSP00000464679.2, ENST00000580918.2
    Conserved Domains (1) summary
    COG0474
    Location:9821333
    MgtA; Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism]
  3. NM_001351202.2NP_001338131.1  transmembrane protein 94 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC100787, H06743, KF456321
    Consensus CDS
    CCDS92392.1
    UniProtKB/TrEMBL
    J3KRN3, J3QLC5
    Related
    ENSP00000463487.2, ENST00000578853.2
    Conserved Domains (1) summary
    cl02929
    Location:12041313
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
  4. NM_001351203.2NP_001338132.1  transmembrane protein 94 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC100787, H06743, KF456321
    UniProtKB/TrEMBL
    B4DGC6
    Conserved Domains (1) summary
    cl02929
    Location:12291338
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
  5. NM_014738.6NP_055553.3  transmembrane protein 94 isoform 1

    See identical proteins and their annotated locations for NP_055553.3

    Status: VALIDATED

    Source sequence(s)
    CN307648, D83779, DA317199, DB545285, H06743
    Consensus CDS
    CCDS32732.1
    UniProtKB/Swiss-Prot
    C9JL75, O75536, Q12767, Q86XF1
    UniProtKB/TrEMBL
    J3KRN3
    Related
    ENSP00000313885.7, ENST00000314256.12
    Conserved Domains (1) summary
    COG0474
    Location:9781329
    MgtA; Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    75456635..75500452
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047437170.1XP_047293126.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X26

    UniProtKB/TrEMBL
    J3QSG7
  2. XM_047437172.1XP_047293128.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X28

    UniProtKB/Swiss-Prot
    C9JL75, O75536, Q12767, Q86XF1
  3. XM_047437179.1XP_047293135.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X37

    UniProtKB/TrEMBL
    J3QLC5
  4. XM_011525514.3XP_011523816.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X5

    See identical proteins and their annotated locations for XP_011523816.1

    UniProtKB/TrEMBL
    J3KRN3
  5. XM_047437164.1XP_047293120.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X19

  6. XM_047437159.1XP_047293115.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X9

  7. XM_047437181.1XP_047293137.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X39

  8. XM_047437171.1XP_047293127.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X27

  9. XM_047437174.1XP_047293130.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X30

  10. XM_047437184.1XP_047293140.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X42

  11. XM_047437163.1XP_047293119.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X18

  12. XM_047437177.1XP_047293133.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X35

  13. XM_047437186.1XP_047293142.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X44

  14. XM_047437178.1XP_047293134.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X36

  15. XM_047437158.1XP_047293114.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X7

  16. XM_047437167.1XP_047293123.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X23

    Related
    ENST00000581085.5
  17. XM_047437168.1XP_047293124.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X24

  18. XM_017025440.3XP_016880929.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X11

    UniProtKB/TrEMBL
    J3KRN3
  19. XM_047437182.1XP_047293138.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X40

    UniProtKB/TrEMBL
    J3QRY7
    Related
    ENSP00000464437.2, ENST00000577247.6
  20. XM_047437173.1XP_047293129.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X29

  21. XM_047437183.1XP_047293139.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X41

  22. XM_047437176.1XP_047293132.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X33

  23. XM_047437185.1XP_047293141.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X43

  24. XM_047437165.1XP_047293121.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X21

  25. XM_047437187.1XP_047293143.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X45

  26. XM_047437180.1XP_047293136.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X38

  27. XM_017025433.2XP_016880922.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X1

    UniProtKB/TrEMBL
    B4DGC6
  28. XM_017025442.2XP_016880931.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X13

    UniProtKB/TrEMBL
    B4DGC6
  29. XM_017025434.2XP_016880923.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X2

    UniProtKB/TrEMBL
    B4DGC6
  30. XM_017025444.2XP_016880933.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X15

    UniProtKB/TrEMBL
    B4DGC6
  31. XM_017025436.2XP_016880925.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X4

    UniProtKB/TrEMBL
    B4DGC6
  32. XM_005257864.3XP_005257921.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X20

    UniProtKB/TrEMBL
    B4DGC6
    Conserved Domains (1) summary
    COG0474
    Location:9921343
    MgtA; Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism]
  33. XM_047437166.1XP_047293122.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X22

  34. XM_017025438.2XP_016880927.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X8

    UniProtKB/TrEMBL
    B4DGC6
  35. XM_047437169.1XP_047293125.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X25

  36. XM_047437160.1XP_047293116.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X12

  37. XM_017025446.2XP_016880935.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X31

    UniProtKB/TrEMBL
    B4DGC6
  38. XM_047437175.1XP_047293131.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X32

  39. XM_017025435.2XP_016880924.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X3

    UniProtKB/TrEMBL
    B4DGC6
  40. XM_047437162.1XP_047293118.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X17

    Related
    ENST00000585105.5
  41. XM_017025437.2XP_016880926.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X6

    UniProtKB/TrEMBL
    B4DGC6
  42. XM_017025439.2XP_016880928.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X10

    UniProtKB/TrEMBL
    B4DGC6
  43. XM_017025443.2XP_016880932.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X14

    UniProtKB/TrEMBL
    B4DGC6
  44. XM_017025448.2XP_016880937.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X34

    UniProtKB/TrEMBL
    B4DGC6
  45. XM_047437161.1XP_047293117.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X16

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    76350056..76393782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318006.1XP_054173981.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X26

    UniProtKB/TrEMBL
    J3QSG7
  2. XM_054318008.1XP_054173983.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X28

    UniProtKB/Swiss-Prot
    C9JL75, O75536, Q12767, Q86XF1
  3. XM_054318017.1XP_054173992.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X37

    UniProtKB/TrEMBL
    J3QLC5
  4. XM_054317985.1XP_054173960.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X5

  5. XM_054317999.1XP_054173974.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X19

  6. XM_054317989.1XP_054173964.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X9

  7. XM_054318019.1XP_054173994.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X39

  8. XM_054318007.1XP_054173982.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X27

  9. XM_054318010.1XP_054173985.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X30

  10. XM_054318022.1XP_054173997.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X42

  11. XM_054317998.1XP_054173973.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X18

  12. XM_054318015.1XP_054173990.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X35

  13. XM_054318024.1XP_054173999.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X44

  14. XM_054318016.1XP_054173991.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X36

  15. XM_054317987.1XP_054173962.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X7

  16. XM_054318003.1XP_054173978.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X23

  17. XM_054318004.1XP_054173979.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X24

  18. XM_054317991.1XP_054173966.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X11

  19. XM_054318020.1XP_054173995.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X40

    UniProtKB/TrEMBL
    J3QRY7
  20. XM_054318009.1XP_054173984.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X29

  21. XM_054318021.1XP_054173996.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X41

  22. XM_054318013.1XP_054173988.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X33

  23. XM_054318023.1XP_054173998.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X43

  24. XM_054318001.1XP_054173976.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X21

  25. XM_054318025.1XP_054174000.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X45

  26. XM_054318018.1XP_054173993.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X38

  27. XM_054317981.1XP_054173956.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X1

  28. XM_054317993.1XP_054173968.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X13

  29. XM_054317982.1XP_054173957.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X2

  30. XM_054317995.1XP_054173970.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X15

  31. XM_054317984.1XP_054173959.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X4

  32. XM_054318000.1XP_054173975.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X20

  33. XM_054318002.1XP_054173977.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X22

  34. XM_054317988.1XP_054173963.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X8

  35. XM_054318005.1XP_054173980.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X25

  36. XM_054317992.1XP_054173967.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X12

  37. XM_054318011.1XP_054173986.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X31

  38. XM_054318012.1XP_054173987.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X32

  39. XM_054317983.1XP_054173958.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X3

  40. XM_054317997.1XP_054173972.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X17

  41. XM_054317986.1XP_054173961.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X6

  42. XM_054317990.1XP_054173965.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X10

  43. XM_054317994.1XP_054173969.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X14

  44. XM_054318014.1XP_054173989.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X34

  45. XM_054317996.1XP_054173971.1  endoplasmic reticulum magnesium-transporting P-type ATPase isoform X16