Format

Send to:

Choose Destination

STARD8 StAR related lipid transfer domain containing 8 [ Homo sapiens (human) ]

Gene ID: 9754, updated on 1-Jun-2020

Summary

Official Symbol
STARD8provided by HGNC
Official Full Name
StAR related lipid transfer domain containing 8provided by HGNC
Primary source
HGNC:HGNC:19161
See related
Ensembl:ENSG00000130052 MIM:300689
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DLC3; ARHGAP38; STARTGAP3
Summary
This gene encodes a member of a subfamily of Rho GTPase activating proteins that contain a steroidogenic acute regulatory protein related lipid transfer domain. The encoded protein localizes to focal adhesions and may be involved in regulating cell morphology. This protein may also function as a tumor suppressor. [provided by RefSeq, Mar 2010]
Expression
Broad expression in kidney (RPKM 8.5), fat (RPKM 6.6) and 24 other tissues See more
Orthologs

Genomic context

See STARD8 in Genome Data Viewer
Location:
Xq13.1
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (68647669..68725842)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (67867511..67945684)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31 pseudogene 63 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 12 Neighboring gene ACTR3 pseudogene 2 Neighboring gene SERPINE1 mRNA binding protein 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0189, DKFZp686H1668

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
focal adhesion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
stAR-related lipid transfer protein 8
Names
START domain containing 8
StAR-related lipid transfer (START) domain containing 8
deleted in liver cancer 3 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016856.1 RefSeqGene

    Range
    5001..83174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001142503.2NP_001135975.1  stAR-related lipid transfer protein 8 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AL360076, AL732324, BC035587, BQ019015
    Consensus CDS
    CCDS48134.1
    UniProtKB/Swiss-Prot
    Q92502
    Related
    ENSP00000363727.3, ENST00000374599.7
    Conserved Domains (3) summary
    cd08907
    Location:8901094
    START_STARD8-like; C-terminal lipid-binding START domain of mammalian STARD8 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
    cl02570
    Location:649863
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl15755
    Location:3190
    SAM_superfamily; SAM (Sterile alpha motif )
  2. NM_001142504.3NP_001135976.1  stAR-related lipid transfer protein 8 isoform b

    See identical proteins and their annotated locations for NP_001135976.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in the 5' coding region resulting in use of a downstream start codon, compared to variant 1. It encodes isoform b which has a shorter N-terminus than isoform a. Variants 2 and 3 both encode isoform b.
    Source sequence(s)
    AK291747, AL360076, BC035587, BQ019015
    Consensus CDS
    CCDS14390.1
    UniProtKB/Swiss-Prot
    Q92502
    Related
    ENSP00000363725.3, ENST00000374597.3
    Conserved Domains (2) summary
    cd08907
    Location:8101014
    START_STARD8-like; C-terminal lipid-binding START domain of mammalian STARD8 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
    cl02570
    Location:569783
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
  3. NM_014725.4NP_055540.2  stAR-related lipid transfer protein 8 isoform b

    See identical proteins and their annotated locations for NP_055540.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon resulting in use of a downstream start codon, compared to variant 1. It encodes isoform b, which has a shorter N-terminus than isoform a. Variants 2 and 3 both encode isoform b.
    Source sequence(s)
    AL360076, BC035587, BQ019015
    Consensus CDS
    CCDS14390.1
    UniProtKB/Swiss-Prot
    Q92502
    Related
    ENSP00000252336.6, ENST00000252336.10
    Conserved Domains (2) summary
    cd08907
    Location:8101014
    START_STARD8-like; C-terminal lipid-binding START domain of mammalian STARD8 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
    cl02570
    Location:569783
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    68647669..68725842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262314.4XP_005262371.1  stAR-related lipid transfer protein 8 isoform X3

    Conserved Domains (3) summary
    cd08907
    Location:8941098
    START_STARD8-like; C-terminal lipid-binding START domain of mammalian STARD8 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
    cl02570
    Location:653867
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl15755
    Location:3190
    SAM_superfamily; SAM (Sterile alpha motif )
  2. XM_011531070.2XP_011529372.1  stAR-related lipid transfer protein 8 isoform X1

    See identical proteins and their annotated locations for XP_011529372.1

    Conserved Domains (2) summary
    cd08907
    Location:8141018
    START_STARD8-like; C-terminal lipid-binding START domain of mammalian STARD8 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
    cl02570
    Location:573787
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
  3. XM_011531069.3XP_011529371.1  stAR-related lipid transfer protein 8 isoform X2

    See identical proteins and their annotated locations for XP_011529371.1

    UniProtKB/Swiss-Prot
    Q92502
    Conserved Domains (2) summary
    cd08907
    Location:8101014
    START_STARD8-like; C-terminal lipid-binding START domain of mammalian STARD8 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
    cl02570
    Location:569783
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
  4. XM_005262315.3XP_005262372.1  stAR-related lipid transfer protein 8 isoform X1

    See identical proteins and their annotated locations for XP_005262372.1

    Conserved Domains (2) summary
    cd08907
    Location:8141018
    START_STARD8-like; C-terminal lipid-binding START domain of mammalian STARD8 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
    cl02570
    Location:573787
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
Support Center