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ZSCAN12 zinc finger and SCAN domain containing 12 [ Homo sapiens (human) ]

Gene ID: 9753, updated on 24-Nov-2020

Summary

Official Symbol
ZSCAN12provided by HGNC
Official Full Name
zinc finger and SCAN domain containing 12provided by HGNC
Primary source
HGNC:HGNC:13172
See related
Ensembl:ENSG00000158691 MIM:603978
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFP96; ZNF96; ZNF305; ZNF29K1; dJ29K1.2
Expression
Ubiquitous expression in thyroid (RPKM 1.8), ovary (RPKM 1.5) and 25 other tissues See more
Orthologs

Genomic context

See ZSCAN12 in Genome Data Viewer
Location:
6p22.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (28378821..28399768, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (28346598..28367544, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene piggyBac transposable element derived 1 Neighboring gene zinc finger and SCAN domain containing 31 Neighboring gene zinc finger with KRAB and SCAN domains 3 Neighboring gene uncharacterized LOC105374998 Neighboring gene zinc finger protein 968, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0426

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger and SCAN domain-containing protein 12
Names
zinc finger protein 305
zinc finger protein 96

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163391.2NP_001156863.1  zinc finger and SCAN domain-containing protein 12

    See identical proteins and their annotated locations for NP_001156863.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variant 10, encodes the functional protein.
    Source sequence(s)
    Z98745
    Conserved Domains (3) summary
    smart00431
    Location:42152
    SCAN; leucine rich region
    COG5048
    Location:299579
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:499519
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001368124.1NP_001355053.1  zinc finger and SCAN domain-containing protein 12

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variant 1, encodes the functional protein.
    Source sequence(s)
    Z98745

RNA

  1. NR_028077.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL358785, AL602228, BC041661, CX868415
    Related
    ENST00000396827.3
  2. NR_133668.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) does not share exon structure with the protein-coding variant (1). This variant (3) shares 3' exons with variant (2) but uses an alternate 5' exon. This variant is represented as non-coding because it lacks all of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AL358785, CX868415, DB014565, Z98745
  3. NR_133669.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) does not share exon structure with the protein-coding variant (1). This variant (4) shares 3' exons with variant (2) but uses an alternate 5' exon. This variant is represented as non-coding because it lacks all of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AL358785, BI829158, CX868415, DA301736, Z98745
  4. NR_136509.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL358785, AL602228, BC041661, CX868415, Z98745
  5. NR_136510.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site in an internal exon and contains alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL358785, AL602228, BC041661, BF091581, BF091593, CX868415, Z98745
  6. NR_136511.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) contains alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL358785, AL602228, BC041661, CX868415
  7. NR_136512.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate splice site in an internal exon and contains alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL358785, AL602228, BC041661, CX868415, Z98745
  8. NR_136513.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks three exons and contains alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because it lacks the entire ORF found in variant 1.
    Source sequence(s)
    AL358785, AL602228, BC041661, CX868415
  9. NR_160526.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL358785, Z98745
  10. NR_160527.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL358785, Z98745

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    28378821..28399768 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515017.3XP_011513319.1  zinc finger and SCAN domain-containing protein 12 isoform X2

    Conserved Domains (5) summary
    smart00431
    Location:42152
    SCAN; leucine rich region
    COG5048
    Location:299555
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:276296
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:43130
    SCAN; SCAN domain
    pfam13465
    Location:483508
    zf-H2C2_2; Zinc-finger double domain
  2. XM_017011528.2XP_016867017.1  zinc finger and SCAN domain-containing protein 12 isoform X1

    Related
    ENSP00000354305.1, ENST00000361028.5
    Conserved Domains (3) summary
    smart00431
    Location:42152
    SCAN; leucine rich region
    COG5048
    Location:299579
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:499519
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_011515014.3XP_011513316.1  zinc finger and SCAN domain-containing protein 12 isoform X1

    See identical proteins and their annotated locations for XP_011513316.1

    Conserved Domains (3) summary
    smart00431
    Location:42152
    SCAN; leucine rich region
    COG5048
    Location:299579
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:499519
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_011515015.2XP_011513317.1  zinc finger and SCAN domain-containing protein 12 isoform X1

    See identical proteins and their annotated locations for XP_011513317.1

    Conserved Domains (3) summary
    smart00431
    Location:42152
    SCAN; leucine rich region
    COG5048
    Location:299579
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:499519
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. XM_024446598.1XP_024302366.1  zinc finger and SCAN domain-containing protein 12 isoform X1

    Conserved Domains (3) summary
    smart00431
    Location:42152
    SCAN; leucine rich region
    COG5048
    Location:299579
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:499519
    ZF_C2H2; C2H2 Zn finger [structural motif]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001039643.1: Suppressed sequence

    Description
    NM_001039643.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_014724.2: Suppressed sequence

    Description
    NM_014724.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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