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TCAF1 TRPM8 channel associated factor 1 [ Homo sapiens (human) ]

Gene ID: 9747, updated on 3-May-2020

Summary

Official Symbol
TCAF1provided by HGNC
Official Full Name
TRPM8 channel associated factor 1provided by HGNC
Primary source
HGNC:HGNC:22201
See related
Ensembl:ENSG00000198420 MIM:616251
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM115A
Expression
Ubiquitous expression in placenta (RPKM 36.2), brain (RPKM 25.4) and 24 other tissues See more
Orthologs

Genomic context

See TCAF1 in Genome Data Viewer
Location:
7q35
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (143851375..143902198, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (143548461..143599278, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ribosomal protein L26 pseudogene 24 Neighboring gene family with sequence similarity 115, member C pseudogene Neighboring gene TRPM8 channel associated factor 2 pseudogene 1 Neighboring gene uncharacterized LOC112267988 Neighboring gene uncharacterized LOC105375549 Neighboring gene olfactory receptor family 2 subfamily F member 1 Neighboring gene olfactory receptor family 2 subfamily F member 2 Neighboring gene CAPZA1 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ56782, KIAA0738

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ion channel binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion channel binding IDA
Inferred from Direct Assay
more info
PubMed 
ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of anion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of anion channel activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein targeting to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of anion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
TRPM8 channel-associated factor 1
Names
TRP channel-associated factor 1
family with sequence similarity 115, member A
protein FAM115A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206938.2NP_001193867.2  TRPM8 channel-associated factor 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 3' coding region, which results in the use of an early stop codon, compared to variant 1. The resulting protein (isoform 2) has a shorter C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AC004742, AC099548
    Consensus CDS
    CCDS56514.1
    Related
    ENSP00000348220.2, ENST00000355951.2
  2. NM_001206941.2NP_001193870.1  TRPM8 channel-associated factor 1 isoform 3

    See identical proteins and their annotated locations for NP_001193870.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has several differences in its 5' UTR, one of which results in the use of a downstream in-frame start codon, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AC004742, AC099548
    UniProtKB/Swiss-Prot
    Q9Y4C2
    UniProtKB/TrEMBL
    B4DST7
    Conserved Domains (1) summary
    pfam13402
    Location:92464
    Peptidase_M60; Peptidase M60, enhancin and enhancin-like
  3. NM_014719.3NP_055534.2  TRPM8 channel-associated factor 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    AC004742, AC099548
    Consensus CDS
    CCDS5886.1
    Related
    ENSP00000419235.1, ENST00000479870.6
    Conserved Domains (1) summary
    pfam13402
    Location:515888
    Peptidase_M60; Peptidase M60, enhancin and enhancin-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    143851375..143902198 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006716191.2XP_006716254.1  TRPM8 channel-associated factor 1 isoform X1

    See identical proteins and their annotated locations for XP_006716254.1

    UniProtKB/Swiss-Prot
    Q9Y4C2
    Conserved Domains (1) summary
    pfam13402
    Location:515888
    Peptidase_M60; Peptidase M60, enhancin and enhancin-like
  2. XM_005250074.4XP_005250131.1  TRPM8 channel-associated factor 1 isoform X1

    See identical proteins and their annotated locations for XP_005250131.1

    UniProtKB/Swiss-Prot
    Q9Y4C2
    Conserved Domains (1) summary
    pfam13402
    Location:515888
    Peptidase_M60; Peptidase M60, enhancin and enhancin-like
  3. XM_006716192.4XP_006716255.1  TRPM8 channel-associated factor 1 isoform X2

    See identical proteins and their annotated locations for XP_006716255.1

    UniProtKB/Swiss-Prot
    Q9Y4C2
    Conserved Domains (1) summary
    pfam13402
    Location:516888
    Peptidase_M60; Peptidase M60, enhancin and enhancin-like
  4. XM_005250075.3XP_005250132.1  TRPM8 channel-associated factor 1 isoform X1

    See identical proteins and their annotated locations for XP_005250132.1

    UniProtKB/Swiss-Prot
    Q9Y4C2
    Conserved Domains (1) summary
    pfam13402
    Location:515888
    Peptidase_M60; Peptidase M60, enhancin and enhancin-like
  5. XM_005250077.2XP_005250134.1  TRPM8 channel-associated factor 1 isoform X1

    See identical proteins and their annotated locations for XP_005250134.1

    UniProtKB/Swiss-Prot
    Q9Y4C2
    Conserved Domains (1) summary
    pfam13402
    Location:515888
    Peptidase_M60; Peptidase M60, enhancin and enhancin-like
  6. XM_005250076.4XP_005250133.1  TRPM8 channel-associated factor 1 isoform X1

    See identical proteins and their annotated locations for XP_005250133.1

    UniProtKB/Swiss-Prot
    Q9Y4C2
    Conserved Domains (1) summary
    pfam13402
    Location:515888
    Peptidase_M60; Peptidase M60, enhancin and enhancin-like
  7. XM_017012833.2XP_016868322.1  TRPM8 channel-associated factor 1 isoform X2

    UniProtKB/Swiss-Prot
    Q9Y4C2
    Conserved Domains (1) summary
    pfam13402
    Location:516888
    Peptidase_M60; Peptidase M60, enhancin and enhancin-like

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654714.1 Reference GRCh38.p13 PATCHES

    Range
    395677..446408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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