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ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 [ Homo sapiens (human) ]

Gene ID: 9744, updated on 17-Jun-2019

Summary

Official Symbol
ACAP1provided by HGNC
Official Full Name
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1provided by HGNC
Primary source
HGNC:HGNC:16467
See related
Ensembl:ENSG00000072818 MIM:607763
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CENTB1
Expression
Broad expression in lymph node (RPKM 20.4), spleen (RPKM 16.9) and 24 other tissues See more
Orthologs

Genomic context

See ACAP1 in Genome Data Viewer
Location:
17p13.1
Exon count:
22
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (7336506..7354944)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7239848..7254797)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene G protein pathway suppressor 2 Neighboring gene neuralized E3 ubiquitin protein ligase 4 Neighboring gene Sharpr-MPRA regulatory region 1992 Neighboring gene potassium channel tetramerization domain containing 11 Neighboring gene transmembrane protein 95 Neighboring gene TMEM256-PLSCR3 readthrough (NMD candidate) Neighboring gene tyrosine kinase non receptor 1 Neighboring gene phospholipid scramblase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Genome-wide shRNA screening identifies CENTB1/ACAP1, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Arf6 signaling events, organism-specific biosystem (from Pathway Interaction Database)
    Arf6 signaling events, organism-specific biosystem
    Arf6 signaling events
  • Arf6 trafficking events, organism-specific biosystem (from Pathway Interaction Database)
    Arf6 trafficking events, organism-specific biosystem
    Arf6 trafficking events
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Nucleotide-binding Oligomerization Domain (NOD) pathway, organism-specific biosystem (from WikiPathways)
    Nucleotide-binding Oligomerization Domain (NOD) pathway, organism-specific biosystemThe NOD (nucleotide-binding oligomerization domain) proteins NOD1 and NOD2 have important roles in innate immunity as sensors of microbial components derived from bacterial peptidoglycan. The importa...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0050

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
membrane HDA PubMed 
recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
Names
Arf GAP with coiled coil, ANK repeat and PH domains 1
centaurin-beta-1
cnt-b1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014716.4NP_055531.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1

    See identical proteins and their annotated locations for NP_055531.1

    Status: VALIDATED

    Source sequence(s)
    AA356620, AC026954, BC018543
    Consensus CDS
    CCDS11101.1
    UniProtKB/Swiss-Prot
    Q15027
    Related
    ENSP00000158762.3, ENST00000158762.8
    Conserved Domains (7) summary
    cd00204
    Location:592692
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13250
    Location:268364
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    pfam00169
    Location:266360
    PH; PH domain
    pfam01412
    Location:406519
    ArfGap; Putative GTPase activating protein for Arf
    pfam13857
    Location:626680
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:606637
    ANK; ANK repeat [structural motif]
    cl12013
    Location:18217
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    7336506..7354944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451047.1XP_024306815.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X1

    Conserved Domains (5) summary
    cd00204
    Location:518618
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13250
    Location:194290
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    sd00045
    Location:532563
    ANK; ANK repeat [structural motif]
    pfam01412
    Location:332445
    ArfGap; Putative GTPase activating protein for Arf
    cl12013
    Location:1143
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RNA

  1. XR_429827.3 RNA Sequence

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_021160020.1 Reference GRCh38.p13 PATCHES

    Range
    94894..109842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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