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CD79B CD79b molecule [ Homo sapiens (human) ]

Gene ID: 974, updated on 12-Aug-2018

Summary

Official Symbol
CD79Bprovided by HGNC
Official Full Name
CD79b moleculeprovided by HGNC
Primary source
HGNC:HGNC:1699
See related
Ensembl:ENSG00000007312 MIM:147245; Vega:OTTHUMG00000172294
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B29; IGB; AGM6
Summary
The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lymph node (RPKM 118.7), spleen (RPKM 71.5) and 3 other tissues See more
Orthologs

Genomic context

See CD79B in Genome Data Viewer
Location:
17q23.3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (63928736..63932354, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (62006098..62009710, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268204 Neighboring gene IGHD type 1A-2 recombination region Neighboring gene growth hormone locus control region Neighboring gene growth hormone 1 Neighboring gene sodium voltage-gated channel alpha subunit 4 Neighboring gene uncharacterized LOC105371858 Neighboring gene PRR29 antisense RNA 1 Neighboring gene proline rich 29

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Agammaglobulinemia 6, autosomal recessive
MedGen: C3150207 OMIM: 612692 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates CD79B from the surface of dual-positive CD79b/CD20 B cells PubMed
env SDF-1alpha reverses gp120-induced downregulation of CD79b in CD40- and IL-4-activated purified HIV-1 seronegative human peripheral blood B cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, organism-specific biosystem (from REACTOME)
    Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, Fu et al. 1975, Kunkel e...
  • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    B Cell Receptor Signaling Pathway, organism-specific biosystemThe functional B-cell receptor is a multi-protein complex consisting of an antigen binding subunit and a signaling subunit. The antigen binding subunit is the membrane bound immunoglobulin and the si...
  • B cell receptor signaling pathway, organism-specific biosystem (from KEGG)
    B cell receptor signaling pathway, organism-specific biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
  • B cell receptor signaling pathway, conserved biosystem (from KEGG)
    B cell receptor signaling pathway, conserved biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
  • BCR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    BCR signaling pathway, organism-specific biosystem
    BCR signaling pathway
  • CD22 mediated BCR regulation, organism-specific biosystem (from REACTOME)
    CD22 mediated BCR regulation, organism-specific biosystemBCR activation is highly regulated and coreceptors like CD22 (SIGLEC2) set a signalling threshold to prevent aberrant immune response and autoimmune disease (Cyster et al. 1997, Han et al. 2005). CD2...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
    Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
immune response TAS
Traceable Author Statement
more info
PubMed 
protein homooligomerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to bacterium IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
B cell receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
B-cell antigen receptor complex-associated protein beta chain
Names
B-cell-specific glycoprotein B29
CD79b antigen (immunoglobulin-associated beta)
CD79b molecule, immunoglobulin-associated beta
Ig-beta
immunoglobulin-associated B29 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007368.1 RefSeqGene

    Range
    5001..8607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_43

mRNA and Protein(s)

  1. NM_000626.3NP_000617.1  B-cell antigen receptor complex-associated protein beta chain isoform 1 precursor

    See identical proteins and their annotated locations for NP_000617.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 5' coding region, compared to variant 3. The encoded isoform (1) is shorter compared to isoform 3, but has identical N- and C- termini.
    Source sequence(s)
    AA804163, AC127029, M89957
    Consensus CDS
    CCDS11655.1
    UniProtKB/Swiss-Prot
    P40259
    Related
    ENSP00000006750.3, OTTHUMP00000248034, ENST00000006750.7, OTTHUMT00000417711
    Conserved Domains (2) summary
    smart00077
    Location:193212
    ITAM; Immunoreceptor tyrosine-based activation motif
    cd16096
    Location:51142
    IgV_CD79b_beta; Immunoglobulin variable domain (IgV)
  2. NM_001039933.2NP_001035022.1  B-cell antigen receptor complex-associated protein beta chain isoform 3 precursor

    See identical proteins and their annotated locations for NP_001035022.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AA804163, AK222954, M89957
    Consensus CDS
    CCDS42372.1
    UniProtKB/Swiss-Prot
    P40259
    Related
    ENSP00000376544.3, OTTHUMP00000248033, ENST00000392795.7, OTTHUMT00000417710
    Conserved Domains (3) summary
    smart00077
    Location:194213
    ITAM; Immunoreceptor tyrosine-based activation motif
    smart00410
    Location:51143
    IG_like; Immunoglobulin like
    pfam07686
    Location:49143
    V-set; Immunoglobulin V-set domain
  3. NM_001329050.1NP_001315979.1  B-cell antigen receptor complex-associated protein beta chain isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in its 5' coding region compared to variant 3. The encoded isoform (4) is shorter than isoform 3.
    Source sequence(s)
    AA804163, AC127029
    Conserved Domains (2) summary
    smart00077
    Location:90109
    ITAM; Immunoreceptor tyrosine-based activation motif
    pfam13800
    Location:4994
    Sigma_reg_N; Sigma factor regulator N-terminal
  4. NM_021602.3NP_067613.1  B-cell antigen receptor complex-associated protein beta chain isoform 2 precursor

    See identical proteins and their annotated locations for NP_067613.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site and also lacks an exon in the coding region, compared to variant 3. The encoded isoform (2) is shorter compared to isoform 3, but has identical N- and C- termini.
    Source sequence(s)
    AA804163, AK222954, M89957, X83539
    Consensus CDS
    CCDS11656.1
    UniProtKB/Swiss-Prot
    P40259
    Related
    ENSP00000245862.2, OTTHUMP00000248035, ENST00000349817.2, OTTHUMT00000417713
    Conserved Domains (1) summary
    smart00077
    Location:89108
    ITAM; Immunoreceptor tyrosine-based activation motif

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    63928736..63932354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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