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CD79B CD79b molecule [ Homo sapiens (human) ]

Gene ID: 974, updated on 13-Mar-2020

Summary

Official Symbol
CD79Bprovided by HGNC
Official Full Name
CD79b moleculeprovided by HGNC
Primary source
HGNC:HGNC:1699
See related
Ensembl:ENSG00000007312 MIM:147245
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B29; IGB; AGM6
Summary
The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lymph node (RPKM 118.7), spleen (RPKM 71.5) and 3 other tissues See more
Orthologs

Genomic context

See CD79B in Genome Data Viewer
Location:
17q23.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (63928740..63932331, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (62006098..62009710, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268204 Neighboring gene IGHD type 1A-2 recombination region Neighboring gene growth hormone locus control region Neighboring gene growth hormone 1 Neighboring gene sodium voltage-gated channel alpha subunit 4 Neighboring gene uncharacterized LOC105371858 Neighboring gene PRR29 antisense RNA 1 Neighboring gene proline rich 29

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Agammaglobulinemia 6, autosomal recessive
MedGen: C3150207 OMIM: 612692 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates CD79B from the surface of dual-positive CD79b/CD20 B cells PubMed
env SDF-1alpha reverses gp120-induced downregulation of CD79b in CD40- and IL-4-activated purified HIV-1 seronegative human peripheral blood B cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
immune response TAS
Traceable Author Statement
more info
PubMed 
response to bacterium IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
B cell receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
B-cell antigen receptor complex-associated protein beta chain
Names
B-cell-specific glycoprotein B29
CD79b antigen (immunoglobulin-associated beta)
CD79b molecule, immunoglobulin-associated beta
Ig-beta
immunoglobulin-associated B29 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007368.1 RefSeqGene

    Range
    5001..8607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_43

mRNA and Protein(s)

  1. NM_000626.4NP_000617.1  B-cell antigen receptor complex-associated protein beta chain isoform 1 precursor

    See identical proteins and their annotated locations for NP_000617.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 5' coding region, compared to variant 3. The encoded isoform (1) is shorter compared to isoform 3, but has identical N- and C- termini.
    Source sequence(s)
    AA804163, AC127029, M89957
    Consensus CDS
    CCDS11655.1
    UniProtKB/Swiss-Prot
    P40259
    Related
    ENSP00000006750.3, ENST00000006750.7
    Conserved Domains (2) summary
    smart00077
    Location:193212
    ITAM; Immunoreceptor tyrosine-based activation motif
    cd16096
    Location:51142
    IgV_CD79b_beta; Immunoglobulin variable domain (IgV)
  2. NM_001039933.3NP_001035022.1  B-cell antigen receptor complex-associated protein beta chain isoform 3 precursor

    See identical proteins and their annotated locations for NP_001035022.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AK222954
    Consensus CDS
    CCDS42372.1
    UniProtKB/Swiss-Prot
    P40259
    Related
    ENSP00000376544.3, ENST00000392795.7
    Conserved Domains (3) summary
    smart00077
    Location:194213
    ITAM; Immunoreceptor tyrosine-based activation motif
    smart00410
    Location:51143
    IG_like; Immunoglobulin like
    pfam07686
    Location:49143
    V-set; Immunoglobulin V-set domain
  3. NM_001329050.2NP_001315979.1  B-cell antigen receptor complex-associated protein beta chain isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in its 5' coding region compared to variant 3. The encoded isoform (4) is shorter than isoform 3.
    Source sequence(s)
    AC127029
    Conserved Domains (2) summary
    smart00077
    Location:90109
    ITAM; Immunoreceptor tyrosine-based activation motif
    pfam13800
    Location:4994
    Sigma_reg_N; Sigma factor regulator N-terminal
  4. NM_021602.4NP_067613.1  B-cell antigen receptor complex-associated protein beta chain isoform 2 precursor

    See identical proteins and their annotated locations for NP_067613.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site and also lacks an exon in the coding region, compared to variant 3. The encoded isoform (2) is shorter compared to isoform 3, but has identical N- and C- termini.
    Source sequence(s)
    AK222954, M89957, X83539
    Consensus CDS
    CCDS11656.1
    UniProtKB/Swiss-Prot
    P40259
    Related
    ENSP00000245862.2, ENST00000349817.2
    Conserved Domains (1) summary
    smart00077
    Location:89108
    ITAM; Immunoreceptor tyrosine-based activation motif

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    63928740..63932331 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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