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FAM131B family with sequence similarity 131 member B [ Homo sapiens (human) ]

Gene ID: 9715, updated on 1-Jun-2020

Summary

Official Symbol
FAM131Bprovided by HGNC
Official Full Name
family with sequence similarity 131 member Bprovided by HGNC
Primary source
HGNC:HGNC:22202
See related
Ensembl:ENSG00000159784
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in brain (RPKM 25.5), endometrium (RPKM 3.7) and 1 other tissue See more
Orthologs

Genomic context

See FAM131B in Genome Data Viewer
Location:
7q34
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (143353400..143382304, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (143050493..143079397, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene histidine triad nucleotide binding protein 1 pseudogene 1 Neighboring gene chloride voltage-gated channel 1 Neighboring gene uncharacterized LOC101928397 Neighboring gene uncharacterized LOC100507507 Neighboring gene microRNA 6892 Neighboring gene zyxin Neighboring gene EPH receptor A1 Neighboring gene EPHA1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0773

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031690.3NP_001026860.2  protein FAM131B isoform a

    See identical proteins and their annotated locations for NP_001026860.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC093673
    Consensus CDS
    CCDS47734.1
    UniProtKB/Swiss-Prot
    Q86XD5
    Related
    ENSP00000410603.2, ENST00000443739.6
    Conserved Domains (1) summary
    pfam15010
    Location:67353
    FAM131; Putative cell signalling
  2. NM_001278297.2NP_001265226.1  protein FAM131B isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (c) lacks an alternate internal exon compared to variant a. This difference causes translation initiation at a downstream AUG and results in an isoform (c) with a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC093673
    UniProtKB/Swiss-Prot
    Q86XD5
    UniProtKB/TrEMBL
    O94871
    Conserved Domains (1) summary
    pfam15010
    Location:1259
    FAM131; Putative cell signalling
  3. NM_001371248.1NP_001358177.1  protein FAM131B isoform d

    Status: VALIDATED

    Source sequence(s)
    AC093673
    Related
    ENSP00000386568.1, ENST00000409578.5
  4. NM_001371249.1NP_001358178.1  protein FAM131B isoform e

    Status: VALIDATED

    Source sequence(s)
    AC093673
  5. NM_001371250.1NP_001358179.1  protein FAM131B isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (f), as well as variant b, encodes isoform b.
    Source sequence(s)
    AC092214, AC093673
  6. NM_001371251.1NP_001358180.1  protein FAM131B isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (g), as well as variants h and i, encodes isoform f.
    Source sequence(s)
    AC093673
  7. NM_001371252.1NP_001358181.1  protein FAM131B isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (h), as well as variants g and i, encodes isoform f.
    Source sequence(s)
    AC093673
  8. NM_001371253.1NP_001358182.1  protein FAM131B isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (i), as well as variants g and h, encodes isoform f.
    Source sequence(s)
    AC093673, DA226407
  9. NM_014690.5NP_055505.3  protein FAM131B isoform b

    See identical proteins and their annotated locations for NP_055505.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) differs in the 5' UTR and coding sequence compared to variant a. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC093673
    Consensus CDS
    CCDS5882.1
    UniProtKB/Swiss-Prot
    Q86XD5
    Related
    ENSP00000387147.3, ENST00000409222.7
    Conserved Domains (1) summary
    pfam15010
    Location:39325
    FAM131; Putative cell signalling

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    143353400..143382304 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654714.1 Reference GRCh38.p13 PATCHES

    Range
    1279..1668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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