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H4c14 H4 clustered histone 14 [ Mus musculus (house mouse) ]

Gene ID: 97122, updated on 15-Nov-2022

Summary

Official Symbol
H4c14provided by MGI
Official Full Name
H4 clustered histone 14provided by MGI
Primary source
MGI:MGI:2140113
See related
Ensembl:ENSMUSG00000091405 AllianceGenome:MGI:2140113
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H4; H4c1; H4c2; H4c3; H4c4; H4c6; H4c8; H4c9; H4c11; H4c12; H4c16; H4f16; Hist2h4
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. [provided by RefSeq, Aug 2015]
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Genomic context

See H4c14 in Genome Data Viewer
Location:
3; 3 F2.1
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96170250..96170633, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96262934..96263317, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene H3 clustered histone 14 Neighboring gene predicted gene 20627 Neighboring gene H3 clustered histone 13 Neighboring gene H2B clustered histone 18

Genomic regions, transcripts, and products

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the H4c14 gene: The H4c14 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of chromatin ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of CENP-A containing nucleosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histone H4
Names
histone 2, H4
histone cluster 2, H4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033596.3NP_291074.1  histone H4

    See identical proteins and their annotated locations for NP_291074.1

    Status: REVIEWED

    Source sequence(s)
    AC125099
    Consensus CDS
    CCDS51002.1
    UniProtKB/Swiss-Prot
    P62806, Q9D6Q8
    UniProtKB/TrEMBL
    A0A6P5R0T3, A0A8C6H4M7, B2RTM0
    Related
    ENSMUSP00000129930.2, ENSMUST00000171473.3
    Conserved Domains (1) summary
    PLN00035
    Location:1103
    PLN00035; histone H4; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    96170250..96170633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)