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ULK2 unc-51 like autophagy activating kinase 2 [ Homo sapiens (human) ]

Gene ID: 9706, updated on 25-Nov-2021

Summary

Official Symbol
ULK2provided by HGNC
Official Full Name
unc-51 like autophagy activating kinase 2provided by HGNC
Primary source
HGNC:HGNC:13480
See related
Ensembl:ENSG00000083290 MIM:608650
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATG1B; Unc51.2
Summary
This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]
Expression
Broad expression in testis (RPKM 16.5), brain (RPKM 7.4) and 21 other tissues See more
Orthologs
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Genomic context

See ULK2 in Genome Data Viewer
Location:
17p11.2
Exon count:
29
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (19770828..19867936, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (19674143..19771249, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 3 family member A1 Neighboring gene TBC1 domain family member 25 pseudogene Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 3 Neighboring gene tRNA-Gly (anticodon CCC) 3-1 Neighboring gene A-kinase anchoring protein 10 Neighboring gene Sharpr-MPRA regulatory region 5861 Neighboring gene sperm antigen with calponin homology and coiled-coil domains 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0623

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in autophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in autophagy IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in axon extension IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in late nucleophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of collateral sprouting IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in reticulophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in phagophore assembly site membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in phagophore assembly site membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase ULK2
NP_001136082.1
NP_055498.3
XP_011522389.1
XP_016880913.1
XP_016880914.1
XP_016880915.1
XP_016880916.1
XP_016880917.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047113.1 RefSeqGene

    Range
    4991..102097
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001142610.2NP_001136082.1  serine/threonine-protein kinase ULK2

    See identical proteins and their annotated locations for NP_001136082.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB014523, AC015726, AK314345, AL080134, BC034988, BC039310, DA105030
    Consensus CDS
    CCDS11213.1
    UniProtKB/Swiss-Prot
    Q8IYT8
    Related
    ENSP00000354877.2, ENST00000361658.6
    Conserved Domains (3) summary
    smart00220
    Location:9271
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14201
    Location:2272
    STKc_ULK2; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2
    pfam12063
    Location:8641029
    DUF3543; Domain of unknown function (DUF3543)
  2. NM_014683.4NP_055498.3  serine/threonine-protein kinase ULK2

    See identical proteins and their annotated locations for NP_055498.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB014523, AC005722, AC015726, AK314345, AL080134, BC034988, BC039310, DA105030
    Consensus CDS
    CCDS11213.1
    UniProtKB/Swiss-Prot
    Q8IYT8
    Related
    ENSP00000378914.4, ENST00000395544.9
    Conserved Domains (3) summary
    smart00220
    Location:9271
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14201
    Location:2272
    STKc_ULK2; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2
    pfam12063
    Location:8641029
    DUF3543; Domain of unknown function (DUF3543)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    19770828..19867936 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025425.2XP_016880914.1  serine/threonine-protein kinase ULK2 isoform X1

  2. XM_017025426.2XP_016880915.1  serine/threonine-protein kinase ULK2 isoform X2

  3. XM_017025424.2XP_016880913.1  serine/threonine-protein kinase ULK2 isoform X1

  4. XM_017025428.2XP_016880917.1  serine/threonine-protein kinase ULK2 isoform X5

  5. XM_017025427.2XP_016880916.1  serine/threonine-protein kinase ULK2 isoform X4

  6. XM_011524087.2XP_011522389.1  serine/threonine-protein kinase ULK2 isoform X3

    Conserved Domains (3) summary
    smart00220
    Location:4153
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12063
    Location:746911
    DUF3543; Domain of unknown function (DUF3543)
    cl21453
    Location:1154
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_001752701.2 RNA Sequence

  2. XR_001752700.2 RNA Sequence

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