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PPP6R2 protein phosphatase 6 regulatory subunit 2 [ Homo sapiens (human) ]

Gene ID: 9701, updated on 6-Nov-2022

Summary

Official Symbol
PPP6R2provided by HGNC
Official Full Name
protein phosphatase 6 regulatory subunit 2provided by HGNC
Primary source
HGNC:HGNC:19253
See related
Ensembl:ENSG00000100239 MIM:610877; AllianceGenome:HGNC:19253
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP6R2; SAPS2; SAP190; KIAA0685
Summary
The protein encoded by this gene is a regulatory protein for the protein phosphatase-6 catalytic subunit. Together, these proteins act as a significant T-loop phosphatase for Aurora A, an essential mitotic kinase. Loss of function of either the regulatory or catalytic subunit of protein phosphatase-6 interferes with spindle formation and chromosome alignment. [provided by RefSeq, May 2017]
Expression
Ubiquitous expression in testis (RPKM 24.1), brain (RPKM 12.1) and 25 other tissues See more
Orthologs
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Genomic context

See PPP6R2 in Genome Data Viewer
Location:
22q13.33
Exon count:
29
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (50330774..50445090)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (50851191..50954283)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50781756..50883519)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene plexin B2 Neighboring gene uncharacterized LOC105373096 Neighboring gene DENN domain containing 6B Neighboring gene RNA, 7SL, cytoplasmic 500, pseudogene Neighboring gene microRNA 12114 Neighboring gene SET binding factor 1 Neighboring gene adrenomedullin 2 Neighboring gene myo-inositol oxygenase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 6 regulatory subunit 2
Names
SAPS domain family, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054883.2 RefSeqGene

    Range
    17555..119318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001242898.2NP_001229827.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK302472, AL096767, AL671545, BX545851, DB452735
    Consensus CDS
    CCDS74881.1
    UniProtKB/Swiss-Prot
    O75170
    Related
    ENSP00000478417.1, ENST00000612753.5
    Conserved Domains (2) summary
    pfam04499
    Location:128532
    SAPS; SIT4 phosphatase-associated protein
    cl26464
    Location:703950
    Atrophin-1; Atrophin-1 family
  2. NM_001242899.2NP_001229828.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 2

    See identical proteins and their annotated locations for NP_001229828.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a coding exon and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL096767, BC032664, BX545851
    Consensus CDS
    CCDS56235.1
    UniProtKB/Swiss-Prot
    O75170
    Related
    ENSP00000379090.3, ENST00000395741.7
    Conserved Domains (1) summary
    pfam04499
    Location:128533
    SAPS; SIT4 phosphatase-associated protein
  3. NM_001242900.2NP_001229829.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 4

    See identical proteins and their annotated locations for NP_001229829.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks a coding exon and uses two alternate splice sites in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AB014585, AL096767, BX545851
    Consensus CDS
    CCDS56236.1
    UniProtKB/Swiss-Prot
    O75170
    Related
    ENSP00000352051.3, ENST00000359139.7
    Conserved Domains (1) summary
    pfam04499
    Location:128532
    SAPS; SIT4 phosphatase-associated protein
  4. NM_001351641.2NP_001338570.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL096767, AL671545, AL954743, BX545851
    Conserved Domains (2) summary
    pfam04499
    Location:128533
    SAPS; SIT4 phosphatase-associated protein
    cl26464
    Location:704951
    Atrophin-1; Atrophin-1 family
  5. NM_001351642.2NP_001338571.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL096767, AL671545, AL954743, BX545851
    Conserved Domains (2) summary
    pfam04499
    Location:128532
    SAPS; SIT4 phosphatase-associated protein
    cl26464
    Location:701955
    Atrophin-1; Atrophin-1 family
  6. NM_001351643.2NP_001338572.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variant 1, encodes isoform 1.
    Source sequence(s)
    AL096767, AL671545, AL954743, BX545851
    Consensus CDS
    CCDS74881.1
    Conserved Domains (2) summary
    pfam04499
    Location:128532
    SAPS; SIT4 phosphatase-associated protein
    cl26464
    Location:703950
    Atrophin-1; Atrophin-1 family
  7. NM_001351644.2NP_001338573.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL096767, AL671545, AL954743, BX545851
    Conserved Domains (2) summary
    pfam04499
    Location:128532
    SAPS; SIT4 phosphatase-associated protein
    cl26464
    Location:674928
    Atrophin-1; Atrophin-1 family
  8. NM_001351645.2NP_001338574.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variant 3, encodes isoform 3.
    Source sequence(s)
    AL096767, AL671545, AL954743, BX545851
    Consensus CDS
    CCDS33681.1
    Conserved Domains (2) summary
    pfam04499
    Location:128532
    SAPS; SIT4 phosphatase-associated protein
    cl26464
    Location:676927
    Atrophin-1; Atrophin-1 family
  9. NM_001351646.2NP_001338575.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL096767, AL671545, AL954743, BX545851
    Conserved Domains (2) summary
    pfam04499
    Location:128531
    SAPS; SIT4 phosphatase-associated protein
    cl26464
    Location:675926
    Atrophin-1; Atrophin-1 family
  10. NM_001351647.2NP_001338576.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL096767, AL671545, AL954743, BX545851
    Conserved Domains (2) summary
    pfam04499
    Location:1370
    SAPS; SIT4 phosphatase-associated protein
    cl26464
    Location:602788
    Atrophin-1; Atrophin-1 family
  11. NM_001351648.2NP_001338577.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL096767, AL671545, AL954743, BX545851
    Conserved Domains (2) summary
    pfam04499
    Location:1370
    SAPS; SIT4 phosphatase-associated protein
    cl26464
    Location:575761
    Atrophin-1; Atrophin-1 family
  12. NM_001365836.1NP_001352765.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL096767, AL954743, BC000976, BX545851
    Consensus CDS
    CCDS93184.1
    UniProtKB/Swiss-Prot
    Q9UGB9
    Related
    ENSP00000216061.5, ENST00000216061.9
    Conserved Domains (2) summary
    pfam04499
    Location:128532
    SAPS; SIT4 phosphatase-associated protein
    cl26464
    Location:766957
    Atrophin-1; Atrophin-1 family
  13. NM_014678.5NP_055493.2  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 3

    See identical proteins and their annotated locations for NP_055493.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AL096767, BC000976, BC006568, BX545851, DB452735
    Consensus CDS
    CCDS33681.1
    UniProtKB/Swiss-Prot
    O75170
    Related
    ENSP00000379093.3, ENST00000395744.7
    Conserved Domains (2) summary
    pfam04499
    Location:128532
    SAPS; SIT4 phosphatase-associated protein
    cl26464
    Location:676927
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    50330774..50445090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441654.1XP_047297610.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

  2. XM_047441645.1XP_047297601.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X18

  3. XM_047441659.1XP_047297615.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

  4. XM_011530737.3XP_011529039.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X19

    See identical proteins and their annotated locations for XP_011529039.1

    Conserved Domains (1) summary
    pfam04499
    Location:128533
    SAPS; SIT4 phosphatase-associated protein
  5. XM_011530732.3XP_011529034.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_011529034.1

    Conserved Domains (1) summary
    pfam04499
    Location:150555
    SAPS; SIT4 phosphatase-associated protein
  6. XM_047441646.1XP_047297602.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X6

  7. XM_017029120.2XP_016884609.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

    Conserved Domains (1) summary
    pfam04499
    Location:150554
    SAPS; SIT4 phosphatase-associated protein
  8. XM_047441656.1XP_047297612.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X16

  9. XM_047441655.1XP_047297611.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X13

  10. XM_047441658.1XP_047297614.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

  11. XM_011530736.4XP_011529038.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X19

    See identical proteins and their annotated locations for XP_011529038.1

    Conserved Domains (1) summary
    pfam04499
    Location:128533
    SAPS; SIT4 phosphatase-associated protein
  12. XM_006724431.4XP_006724494.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X20

    Conserved Domains (2) summary
    pfam04499
    Location:128532
    SAPS; SIT4 phosphatase-associated protein
    cl26464
    Location:701962
    Atrophin-1; Atrophin-1 family
  13. XM_047441653.1XP_047297609.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

  14. XM_047441642.1XP_047297598.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X3

  15. XM_047441647.1XP_047297603.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X6

  16. XM_047441651.1XP_047297607.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

  17. XM_047441660.1XP_047297616.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

  18. XM_047441648.1XP_047297604.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X6

  19. XM_011530734.3XP_011529036.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_011529036.1

    Conserved Domains (1) summary
    pfam04499
    Location:150555
    SAPS; SIT4 phosphatase-associated protein
  20. XM_047441650.1XP_047297606.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X7

  21. XM_047441643.1XP_047297599.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X3

  22. XM_047441649.1XP_047297605.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X6

  23. XM_047441644.1XP_047297600.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X4

  24. XM_047441652.1XP_047297608.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

  25. XM_047441657.1XP_047297613.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X16

  26. XM_047441661.1XP_047297617.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

  27. XM_047441638.1XP_047297594.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

  28. XM_011530723.3XP_011529025.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X5

    Conserved Domains (1) summary
    pfam04499
    Location:150555
    SAPS; SIT4 phosphatase-associated protein
  29. XM_011530720.3XP_011529022.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X2

    Conserved Domains (1) summary
    pfam04499
    Location:150555
    SAPS; SIT4 phosphatase-associated protein
  30. XM_011530724.3XP_011529026.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X7

    Conserved Domains (1) summary
    pfam04499
    Location:150555
    SAPS; SIT4 phosphatase-associated protein
  31. XM_011530726.3XP_011529028.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X10

    Conserved Domains (1) summary
    pfam04499
    Location:150555
    SAPS; SIT4 phosphatase-associated protein
  32. XM_011530728.3XP_011529030.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X14

    Conserved Domains (1) summary
    pfam04499
    Location:150555
    SAPS; SIT4 phosphatase-associated protein
  33. XM_011530727.3XP_011529029.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X12

    Conserved Domains (1) summary
    pfam04499
    Location:150555
    SAPS; SIT4 phosphatase-associated protein
  34. XM_011530729.3XP_011529031.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X15

    Conserved Domains (1) summary
    pfam04499
    Location:150555
    SAPS; SIT4 phosphatase-associated protein
  35. XM_011530721.3XP_011529023.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X3

    Conserved Domains (1) summary
    pfam04499
    Location:150554
    SAPS; SIT4 phosphatase-associated protein
  36. XM_024452306.2XP_024308074.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X6

    Conserved Domains (2) summary
    pfam04499
    Location:150554
    SAPS; SIT4 phosphatase-associated protein
    cl26464
    Location:723973
    Atrophin-1; Atrophin-1 family
  37. XM_011530722.3XP_011529024.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X4

    Conserved Domains (1) summary
    pfam04499
    Location:150554
    SAPS; SIT4 phosphatase-associated protein
  38. XM_047441639.1XP_047297595.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

  39. XM_047441641.1XP_047297597.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X11

  40. XM_011530730.3XP_011529032.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X16

    Conserved Domains (1) summary
    pfam04499
    Location:150554
    SAPS; SIT4 phosphatase-associated protein
  41. XM_017029116.2XP_016884605.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X13

  42. XM_011530731.2XP_011529033.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

    Conserved Domains (1) summary
    pfam04499
    Location:150554
    SAPS; SIT4 phosphatase-associated protein
  43. XM_011530739.3XP_011529041.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X19

    See identical proteins and their annotated locations for XP_011529041.1

    Conserved Domains (1) summary
    pfam04499
    Location:128533
    SAPS; SIT4 phosphatase-associated protein
  44. XM_047441640.1XP_047297596.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X9

  45. XM_017029133.2XP_016884622.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X23

  46. XM_011530740.3XP_011529042.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X21

    Conserved Domains (1) summary
    pfam04499
    Location:60465
    SAPS; SIT4 phosphatase-associated protein
  47. XM_047441663.1XP_047297619.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X24

    Related
    ENSP00000391595.2, ENST00000427222.2
  48. XM_047441662.1XP_047297618.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X22

    Related
    ENSP00000384532.3, ENST00000401672.7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    50851191..50954283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)