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CD70 CD70 molecule [ Homo sapiens (human) ]

Gene ID: 970, updated on 7-Jun-2020

Summary

Official Symbol
CD70provided by HGNC
Official Full Name
CD70 moleculeprovided by HGNC
Primary source
HGNC:HGNC:11937
See related
Ensembl:ENSG00000125726 MIM:602840
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD27L; LPFS3; CD27-L; CD27LG; TNFSF7; TNLG8A
Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See CD70 in Genome Data Viewer
Location:
19p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (6581648..6591150, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6582969..6591163, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene transforming growth factor beta receptor 1 pseudogene Neighboring gene chloride intracellular channel 4 pseudogene 2 Neighboring gene ribosomal protein L7 pseudogene 50 Neighboring gene TNF superfamily member 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
B cell mediated immunity IMP
Inferred from Mutant Phenotype
more info
PubMed 
B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell mediated immunity IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of T cell proliferation TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
CD70 antigen
Names
CD27 ligand
Ki-24 antigen
surface antigen CD70
tumor necrosis factor ligand 8A
tumor necrosis factor ligand superfamily member 7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252.5NP_001243.1  CD70 antigen isoform 1

    See identical proteins and their annotated locations for NP_001243.1

    Status: REVIEWED

    Source sequence(s)
    AC008760, KC877696
    Consensus CDS
    CCDS12170.1
    UniProtKB/Swiss-Prot
    P32970
    UniProtKB/TrEMBL
    A0A0U5JA32
    Related
    ENSP00000245903.2, ENST00000245903.4
    Conserved Domains (1) summary
    smart00207
    Location:73191
    TNF; Tumour necrosis factor family
  2. NM_001330332.2NP_001317261.1  CD70 antigen isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC008760, AK298467
    Consensus CDS
    CCDS82283.1
    UniProtKB/Swiss-Prot
    P32970
    Related
    ENSP00000395294.2, ENST00000423145.7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    6581648..6591150 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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