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Ptges2 prostaglandin E synthase 2 [ Mus musculus (house mouse) ]

Gene ID: 96979, updated on 31-Jan-2019

Summary

Official Symbol
Ptges2provided by MGI
Official Full Name
prostaglandin E synthase 2provided by MGI
Primary source
MGI:MGI:1917592
See related
Ensembl:ENSMUSG00000026820
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gbf1; Pges2; C79137; Mpges2; 0610038H10Rik
Summary
The protein encoded by this gene is a Golgi membrane-associated prostaglandin E synthase candidate, which is capable of catalyzing the conversion of prostaglandin H2 to prostaglandin E2 in vitro. However, a study using mice deficient of this gene suggests that this enzyme does not contribute to prostaglandin E2 biosynthesis in vivo. This protein is synthesized as a Golgi membrane-bound protein, but its N-terminal hydrophobic region is cleaved off during protein maturation to produce the predominant soluble truncated form that still retains the enzyme activity. This soluble protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE), possibly via an interaction with CAAAT/enhancer-binding protein-beta. [provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in adrenal adult (RPKM 50.1), duodenum adult (RPKM 41.1) and 28 other tissues See more
Orthologs

Genomic context

See Ptges2 in Genome Data Viewer
Location:
2; 2 B
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (32395890..32402740)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (32251410..32258260)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1110008P14 gene Neighboring gene lipocalin 2 Neighboring gene 60S ribosomal protein L15-like Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 Neighboring gene nuclear apoptosis inducing factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC6845

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
electron transfer activity IEA
Inferred from Electronic Annotation
more info
 
isomerase activity IEA
Inferred from Electronic Annotation
more info
 
prostaglandin-E synthase activity ISO
Inferred from Sequence Orthology
more info
 
protein disulfide oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 
fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
prostaglandin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
prostaglandin metabolic process IEA
Inferred from Electronic Annotation
more info
 
secretion IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion HDA PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
prostaglandin E synthase 2
Names
GATE-binding factor 1
mPGES-2
microsomal prostaglandin E synthase 2
NP_598544.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133783.2NP_598544.2  prostaglandin E synthase 2

    See identical proteins and their annotated locations for NP_598544.2

    Status: REVIEWED

    Source sequence(s)
    AK050616, BE956255, CX221758
    Consensus CDS
    CCDS15914.1
    UniProtKB/Swiss-Prot
    Q8BWM0
    Related
    ENSMUSP00000028162.3, ENSMUST00000028162.4
    Conserved Domains (3) summary
    cd03197
    Location:223371
    GST_C_mPGES2; C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2
    COG0625
    Location:101368
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cd03040
    Location:100176
    GST_N_mPGES2; GST_N family; microsomal Prostaglandin E synthase Type 2 (mPGES2) subfamily; mPGES2 is a membrane-anchored dimeric protein containing a CXXC motif which catalyzes the isomerization of PGH2 to PGE2. Unlike cytosolic PGE synthase (cPGES) and microsomal ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    32395890..32402740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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