Format

Send to:

Choose Destination

TRAM2 translocation associated membrane protein 2 [ Homo sapiens (human) ]

Gene ID: 9697, updated on 1-Aug-2020

Summary

Official Symbol
TRAM2provided by HGNC
Official Full Name
translocation associated membrane protein 2provided by HGNC
Primary source
HGNC:HGNC:16855
See related
Ensembl:ENSG00000065308 MIM:608485
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[supplied by OMIM, Jul 2004]
Expression
Broad expression in placenta (RPKM 12.1), testis (RPKM 6.9) and 23 other tissues See more
Orthologs

Genomic context

See TRAM2 in Genome Data Viewer
Location:
6p12.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (52497405..52577060, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (52362200..52441862, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene progestin and adipoQ receptor family member 8 Neighboring gene VISTA enhancer hs2064 Neighboring gene EF-hand domain containing 1 Neighboring gene uncharacterized LOC107986603 Neighboring gene FOXA motif-containing MPRA enhancer 62 Neighboring gene TRAM2 antisense RNA 1 (head to head)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0057

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane, translocation IEA
Inferred from Electronic Annotation
more info
 
collagen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein insertion into ER membrane IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
rough endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
translocating chain-associated membrane protein 2
Names
TRAM-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012288.4NP_036420.1  translocating chain-associated membrane protein 2

    See identical proteins and their annotated locations for NP_036420.1

    Status: REVIEWED

    Source sequence(s)
    AL049611, BC028121, D31762
    Consensus CDS
    CCDS34477.1
    UniProtKB/Swiss-Prot
    Q15035
    UniProtKB/TrEMBL
    A0A024RD84
    Related
    ENSP00000182527.3, ENST00000182527.4
    Conserved Domains (2) summary
    smart00724
    Location:112321
    TLC; TRAM, LAG1 and CLN8 homology domains
    pfam08390
    Location:49110
    TRAM1; TRAM1-like protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    52497405..52577060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515005.2XP_011513307.1  translocating chain-associated membrane protein 2 isoform X1

    Conserved Domains (2) summary
    smart00724
    Location:75284
    TLC; TRAM, LAG1 and CLN8 homology domains
    pfam08390
    Location:2573
    TRAM1; TRAM1-like protein
Support Center