U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CROCC ciliary rootlet coiled-coil, rootletin [ Homo sapiens (human) ]

Gene ID: 9696, updated on 5-Aug-2022

Summary

Official Symbol
CROCCprovided by HGNC
Official Full Name
ciliary rootlet coiled-coil, rootletinprovided by HGNC
Primary source
HGNC:HGNC:21299
See related
Ensembl:ENSG00000058453 MIM:615776; AllianceGenome:HGNC:21299
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ROLT; CROCC1; TAX1BP2
Summary
Predicted to enable kinesin binding activity and structural molecule activity. Involved in several processes, including centriole-centriole cohesion; positive regulation of cilium assembly; and positive regulation of protein localization to cilium. Located in cytoskeleton; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in skin (RPKM 4.6), spleen (RPKM 3.7) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CROCC in Genome Data Viewer
Location:
1p36.13
Exon count:
39
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (16914085..16972964)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (16732378..16783391)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (17248426..17299459)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 252 Neighboring gene RNA, U1 small nuclear 2 Neighboring gene uncharacterized LOC105376806 Neighboring gene microfibril associated protein 2 Neighboring gene ATPase cation transporting 13A2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0445

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables kinesin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
enables structural molecule activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in cellular homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in centriole-centriole cohesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in centrosome cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ciliary basal body organization IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial structure maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of localization in cell IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of organelle localization IEA
Inferred from Electronic Annotation
more info
 
involved_in photoreceptor cell maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to cilium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to organelle IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in 9+2 motile cilium IEA
Inferred from Electronic Annotation
more info
 
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary rootlet ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in extracellular exosome HDA PubMed 
located_in photoreceptor inner segment IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in subapical part of cell IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rootletin
Names
Tax1-binding protein 2
ciliary rootlet coiled-coil protein
rootletin, ciliary rootlet protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014675.5NP_055490.4  rootletin

    See identical proteins and their annotated locations for NP_055490.4

    Status: VALIDATED

    Source sequence(s)
    AL049569, BK005505, BX284668, KF495875
    Consensus CDS
    CCDS30616.1
    UniProtKB/Swiss-Prot
    Q5TZA2, Q7Z5D7
    Related
    ENSP00000364691.4, ENST00000375541.10
    Conserved Domains (3) summary
    COG1196
    Location:11351866
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:6131426
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15035
    Location:156333
    Rootletin; Ciliary rootlet component, centrosome cohesion

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    16914085..16972964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435134.1XP_047291090.1  rootletin isoform X4

  2. XM_047435120.1XP_047291076.1  rootletin isoform X4

  3. XM_006711058.4XP_006711121.1  rootletin isoform X4

    Conserved Domains (3) summary
    COG1196
    Location:10631794
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:5411354
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15035
    Location:84261
    Rootletin; Ciliary rootlet component, centrosome cohesion
  4. XM_047435135.1XP_047291091.1  rootletin isoform X5

  5. XM_047435136.1XP_047291092.1  rootletin isoform X6

  6. XM_047435115.1XP_047291071.1  rootletin isoform X2

  7. XM_047435117.1XP_047291073.1  rootletin isoform X3

  8. XM_047435114.1XP_047291070.1  rootletin isoform X1

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791756.1 Reference GRCh38.p14 PATCHES

    Range
    1337104..1388138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    16732378..16783391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)