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CROCC ciliary rootlet coiled-coil, rootletin [ Homo sapiens (human) ]

Gene ID: 9696, updated on 4-Jul-2021

Summary

Official Symbol
CROCCprovided by HGNC
Official Full Name
ciliary rootlet coiled-coil, rootletinprovided by HGNC
Primary source
HGNC:HGNC:21299
See related
Ensembl:ENSG00000058453 MIM:615776
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ROLT; TAX1BP2
Expression
Ubiquitous expression in skin (RPKM 4.6), spleen (RPKM 3.7) and 25 other tissues See more
Orthologs
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Genomic context

See CROCC in Genome Data Viewer
Location:
1p36.13
Exon count:
39
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (16914082..16972979)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (17248426..17299459)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985101 Neighboring gene tRNA-Asn (anticodon GTT) 4-1 Neighboring gene RNA, U1 small nuclear 2 Neighboring gene uncharacterized LOC105376806 Neighboring gene microfibril associated protein 2 Neighboring gene ATPase cation transporting 13A2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0445

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables kinesin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
enables structural molecule activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in 9+2 motile cilium IEA
Inferred from Electronic Annotation
more info
 
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary rootlet ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in extracellular exosome HDA PubMed 
located_in photoreceptor inner segment IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in subapical part of cell IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rootletin
Names
Tax1-binding protein 2
ciliary rootlet coiled-coil protein
rootletin, ciliary rootlet protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014675.5NP_055490.4  rootletin

    See identical proteins and their annotated locations for NP_055490.4

    Status: VALIDATED

    Source sequence(s)
    AL049569, BK005505, BX284668, KF495875
    Consensus CDS
    CCDS30616.1
    UniProtKB/Swiss-Prot
    Q5TZA2
    Related
    ENSP00000364691.4, ENST00000375541.10
    Conserved Domains (3) summary
    COG1196
    Location:11351866
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:6131426
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15035
    Location:156333
    Rootletin; Ciliary rootlet component, centrosome cohesion

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    16914082..16972979
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711058.3XP_006711121.1  rootletin isoform X8

    Conserved Domains (3) summary
    COG1196
    Location:10631794
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:5411354
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15035
    Location:84261
    Rootletin; Ciliary rootlet component, centrosome cohesion
  2. XM_017002914.2XP_016858403.2  rootletin isoform X5

    Conserved Domains (2) summary
    pfam15035
    Location:290467
    Rootletin; Ciliary rootlet component, centrosome cohesion
    cl25732
    Location:7471560
    SMC_N; RecF/RecN/SMC N terminal domain
  3. XM_024451092.1XP_024306860.1  rootletin isoform X7

    Conserved Domains (2) summary
    pfam15035
    Location:290467
    Rootletin; Ciliary rootlet component, centrosome cohesion
    cl25732
    Location:7471560
    SMC_N; RecF/RecN/SMC N terminal domain
  4. XM_017002913.2XP_016858402.2  rootletin isoform X2

    Conserved Domains (2) summary
    pfam15035
    Location:290467
    Rootletin; Ciliary rootlet component, centrosome cohesion
    cl25732
    Location:7471560
    SMC_N; RecF/RecN/SMC N terminal domain
  5. XM_011542470.3XP_011540772.2  rootletin isoform X4

    Conserved Domains (2) summary
    pfam15035
    Location:290467
    Rootletin; Ciliary rootlet component, centrosome cohesion
    cl25732
    Location:7471560
    SMC_N; RecF/RecN/SMC N terminal domain
  6. XM_024451090.1XP_024306858.1  rootletin isoform X3

    Conserved Domains (4) summary
    pfam04111
    Location:649784
    APG6; Autophagy protein Apg6
    pfam15035
    Location:290467
    Rootletin; Ciliary rootlet component, centrosome cohesion
    cl25732
    Location:7191532
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26309
    Location:176391
    MscS_TM; Mechanosensitive ion channel inner membrane domain 1
  7. XM_011542468.2XP_011540770.2  rootletin isoform X1

    Conserved Domains (2) summary
    pfam15035
    Location:290467
    Rootletin; Ciliary rootlet component, centrosome cohesion
    cl25732
    Location:7471560
    SMC_N; RecF/RecN/SMC N terminal domain
  8. XM_017002915.2XP_016858404.2  rootletin isoform X6

    Conserved Domains (3) summary
    pfam15035
    Location:290467
    Rootletin; Ciliary rootlet component, centrosome cohesion
    cl25732
    Location:11051836
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26309
    Location:176391
    MscS_TM; Mechanosensitive ion channel inner membrane domain 1

RNA

  1. XR_002958164.1 RNA Sequence

  2. XR_002958163.1 RNA Sequence

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