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BZW1 basic leucine zipper and W2 domains 1 [ Homo sapiens (human) ]

Gene ID: 9689, updated on 6-Jul-2025
Official Symbol
BZW1provided by HGNC
Official Full Name
basic leucine zipper and W2 domains 1provided by HGNC
Primary source
HGNC:HGNC:18380
See related
Ensembl:ENSG00000082153 MIM:619252; AllianceGenome:HGNC:18380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
5MP2; BZAP45; Nbla10236
Summary
Enables RNA binding activity and cadherin binding activity. Involved in regulation of translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in testis (RPKM 73.8), adrenal (RPKM 67.5) and 25 other tissues See more
Orthologs
mouse all
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See BZW1 in Genome Data Viewer
Location:
2q33.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (200811589..200827338)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (201295023..201310790)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (201676312..201692061)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene AOX3P-AOX2P readthrough, transcribed pseudogene Neighboring gene aldehyde oxidase 3, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16961 Neighboring gene long intergenic non-protein coding RNA 1792 Neighboring gene aldehyde oxidase 2, pseudogene Neighboring gene RNA, U1 small nuclear 133, pseudogene Neighboring gene AOX3P-AOX2P intron CAGE-defined mid-level expression enhancer Neighboring gene BZW1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12227 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:201676955-201677470 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:201677471-201677986 Neighboring gene RNA, U6 small nuclear 31, pseudogene Neighboring gene BICD cargo adaptor 1 pseudogene 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. BZW1 promotes cell proliferation in prostate cancer by regulating TGF-β1/Smad pathway. Shi Z, et al. Cell Cycle, 2021 May. PMID 33886419, Free PMC Article
  2. BZW1 Facilitates Glycolysis and Promotes Tumor Growth in Pancreatic Ductal Adenocarcinoma Through Potentiating eIF2α Phosphorylation. Li Z, et al. Gastroenterology, 2022 Apr. PMID 34951995, Free PMC Article
  3. [Overexpression of BZW1 promotes invasion and metastasis of gastric cancer cells by regulating Wnt/β-catenin signaling and promoting epithelial-mesenchymal transition]. Zhang W, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2024 Feb 20. PMID 38501421, Free PMC Article
  4. BZW1 is a prognostic and immunological biomarker in pancreatic adenocarcinoma. Luo A, et al. Medicine (Baltimore), 2024 Feb 2. PMID 38306570, Free PMC Article
  5. Overexpression of BZW1 is an independent poor prognosis marker and its down-regulation suppresses lung adenocarcinoma metastasis. Chiou J, et al. Sci Rep, 2019 Oct 10. PMID 31601833, Free PMC Article

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [Overexpression of BZW1 promotes invasion and metastasis of gastric cancer cells by regulating Wnt/beta-catenin signaling and promoting epithelial-mesenchymal transition].
    Title: [Overexpression of BZW1 promotes invasion and metastasis of gastric cancer cells by regulating Wnt/β-catenin signaling and promoting epithelial-mesenchymal transition].
  2. BZW1 is a prognostic and immunological biomarker in pancreatic adenocarcinoma.
    Title: BZW1 is a prognostic and immunological biomarker in pancreatic adenocarcinoma.
  3. Activation of BZW1 by CEBPB in macrophages promotes eIF2alpha phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice.
    Title: Activation of BZW1 by CEBPB in macrophages promotes eIF2α phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice.
  4. BZW1 Facilitates Glycolysis and Promotes Tumor Growth in Pancreatic Ductal Adenocarcinoma Through Potentiating eIF2alpha Phosphorylation.
    Title: BZW1 Facilitates Glycolysis and Promotes Tumor Growth in Pancreatic Ductal Adenocarcinoma Through Potentiating eIF2α Phosphorylation.
  5. BZW1 promotes cell proliferation in prostate cancer by regulating TGF-beta1/Smad pathway.
    Title: BZW1 promotes cell proliferation in prostate cancer by regulating TGF-β1/Smad pathway.
  6. LncRNA NEAT1 promotes glioma cancer progression via regulation of miR-98-5p/BZW1.
    Title: LncRNA NEAT1 promotes glioma cancer progression via regulation of miR-98-5p/BZW1.
  7. Long noncoding RNA NEAT1 modifies cell proliferation, colony formation, apoptosis, migration and invasion via the miR4500/BZW1 axis in ovarian cancer.
    Title: Long non‑coding RNA NEAT1 modifies cell proliferation, colony formation, apoptosis, migration and invasion via the miR‑4500/BZW1 axis in ovarian cancer.
  8. Overexpression of BZW1 is an independent poor prognosis marker and its down-regulation suppresses lung adenocarcinoma metastasis.
    Title: Overexpression of BZW1 is an independent poor prognosis marker and its down-regulation suppresses lung adenocarcinoma metastasis.
  9. results reveal a surprising role for BZW1 and BZW2 in maintaining homeostatic stringency of start codon selection, and taking into account recent biochemical, genetic and structural insights into eukaryotic initiation, suggest a model for BZW1 and BZW2 function
    Title: Translational autoregulation of BZW1 and BZW2 expression by modulating the stringency of start codon selection.
  10. Data indicate taht candidate genes ACTB, BZW, OCM, MACC1, NXPH1, PRPS1L1, RAC1 and RPA3, which lie within the DFNB90 region, were sequenced and no potentially causal variants were identified.
    Title: Novel autosomal recessive nonsyndromic hearing impairment locus DFNB90 maps to 7p22.1-p15.3.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0005

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables cadherin binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
Preferred Names
eIF5-mimic protein 2
Names
basic leucine zipper and W2 domain-containing protein 1
basic leucine-zipper protein BZAP45
putative protein product of Nbla10236

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001207067.2 → NP_001193996.1  eIF5-mimic protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001193996.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.
    Source sequence(s)
    AB074176, AC005037, AC007163, AL833518
    Consensus CDS
    CCDS56156.1
    UniProtKB/Swiss-Prot
    B4DLZ8, B4DWF7, Q14281, Q15394, Q7L1Q6, Q9BUY0
    UniProtKB/TrEMBL
    Q53FN7
    Related
    ENSP00000386474.1, ENST00000409600.6
    Conserved Domains (1) summary
    cd11560
    Location:217 → 406
    W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins

  2. NM_001207068.3 → NP_001193997.1  eIF5-mimic protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001193997.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate 5' terminal exon, compared to variant 1. It encodes isoform 2, which is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AB074176, AC005037, AC007163, AK297227, BM969732
    Consensus CDS
    CCDS56155.1
    UniProtKB/TrEMBL
    Q53FN7
    Related
    ENSP00000394316.2, ENST00000452790.6
    Conserved Domains (1) summary
    cd11560
    Location:249 → 438
    W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins

  3. NM_001207069.2 → NP_001193998.1  eIF5-mimic protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001193998.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' terminal exon, compared to variant 1. It encodes isoform 3, which is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC005037, AC007163, AK301511, CB055242
    Consensus CDS
    CCDS56154.1
    UniProtKB/TrEMBL
    Q53FN7
    Related
    ENSP00000386837.1, ENST00000409226.5
    Conserved Domains (1) summary
    cd11560
    Location:221 → 410
    W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins

  4. NM_001321688.2 → NP_001308617.1  eIF5-mimic protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005037, AC007163, BM969732, D13630
    Consensus CDS
    CCDS56156.1
    UniProtKB/Swiss-Prot
    B4DLZ8, B4DWF7, Q14281, Q15394, Q7L1Q6, Q9BUY0
    UniProtKB/TrEMBL
    Q53FN7
    Conserved Domains (1) summary
    cd11560
    Location:217 → 406
    W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins

  5. NM_001321690.1 → NP_001308619.1  eIF5-mimic protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007163, BM969732, D13630
    Consensus CDS
    CCDS56156.1
    UniProtKB/Swiss-Prot
    B4DLZ8, B4DWF7, Q14281, Q15394, Q7L1Q6, Q9BUY0
    UniProtKB/TrEMBL
    Q53FN7
    Conserved Domains (1) summary
    cd11560
    Location:217 → 406
    W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins

  6. NM_001321691.2 → NP_001308620.1  eIF5-mimic protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC005037, AC007163, BM969732, D13630
    UniProtKB/TrEMBL
    Q53FN7
    Conserved Domains (1) summary
    cl17013
    Location:217 → 372
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

  7. NM_001321693.2 → NP_001308622.1  eIF5-mimic protein 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC005037, AC007163, BM969732, D13630
    UniProtKB/TrEMBL
    Q53FN7
    Conserved Domains (1) summary
    cd11560
    Location:158 → 347
    W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins

  8. NM_001321694.2 → NP_001308623.1  eIF5-mimic protein 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC005037, AC007163, AK096489, BM969732, D13630
    Conserved Domains (1) summary
    cd11560
    Location:133 → 322
    W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins

  9. NM_014670.4 → NP_055485.2  eIF5-mimic protein 2 isoform 4

    See identical proteins and their annotated locations for NP_055485.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform 4, which is shorter than isoform 1.
    Source sequence(s)
    AA868237, AC005037, AC007163, BC001804, DC386317
    UniProtKB/TrEMBL
    Q53FN7
    Conserved Domains (1) summary
    cl17013
    Location:217 → 340
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    200811589..200827338
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005393.2 → XP_016860882.1  eIF5-mimic protein 2 isoform X1

    Conserved Domains (1) summary
    cd11560
    Location:133 → 322
    W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    201295023..201310790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344721.1 → XP_054200696.1  eIF5-mimic protein 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7L1Q6.1 GenPept UniProtKB/Swiss-Prot:Q7L1Q6

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