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N4BP1 NEDD4 binding protein 1 [ Homo sapiens (human) ]

Gene ID: 9683, updated on 22-Sep-2022

Summary

Official Symbol
N4BP1provided by HGNC
Official Full Name
NEDD4 binding protein 1provided by HGNC
Primary source
HGNC:HGNC:29850
See related
Ensembl:ENSG00000102921 MIM:619138; AllianceGenome:HGNC:29850
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables mRNA binding activity; ribonuclease activity; and ubiquitin binding activity. Involved in cellular response to UV and negative regulation of viral genome replication. Predicted to be located in cytosol and nucleolus. Predicted to be active in PML body. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung (RPKM 13.3), esophagus (RPKM 11.1) and 25 other tissues See more
Orthologs
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Genomic context

See N4BP1 in Genome Data Viewer
Location:
16q12.1
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (48538726..48610180, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (54336403..54407853, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (48572637..48644091, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene molybdenum cofactor synthesis 1 pseudogene 1 Neighboring gene ribosomal protein S2 pseudogene 44 Neighboring gene probable ribosome biogenesis protein RLP24 Neighboring gene uncharacterized LOC124903687 Neighboring gene uncharacterized LOC105371240 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis.
EBI GWAS Catalog
Genome-wide association study of autistic-like traits in a general population study of young adults.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31821, KIAA0615, MGC176730

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in PML body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in PML body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153029.4NP_694574.3  NEDD4-binding protein 1

    See identical proteins and their annotated locations for NP_694574.3

    Status: VALIDATED

    Source sequence(s)
    AB014515, AK026937, AK056383, AK124782, AL831882, BC051897
    Consensus CDS
    CCDS45479.1
    UniProtKB/Swiss-Prot
    O75113, Q2YDX1
    Related
    ENSP00000262384.3, ENST00000262384.4
    Conserved Domains (1) summary
    pfam11977
    Location:616769
    RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    48538726..48610180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523482.2XP_011521784.1  NEDD4-binding protein 1 isoform X1

    Conserved Domains (1) summary
    pfam11977
    Location:616746
    RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

RNA

  1. XR_007064930.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    54336403..54407853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_014664.1: Suppressed sequence

    Description
    NM_014664.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.